Method for preparing low-acid water-soluble ginkgo biloba extract

A technology of Ginkgo biloba and extract, which is applied in the field of preparation of low-acid water-soluble Ginkgo biloba extract, can solve the problems of cumbersome steps, increased production cost, and no methanol residue, and achieve safe and effective products and easy operation Effect

Active Publication Date: 2017-05-31
ZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Firstly, the steps are relatively cumbersome, secondly, the use of high-concentration organic solvents increases the production cost, and finally, it is also a big problem to remove the added co-solvent to make the products meet the national standards
This patent only discloses that the method of removing methanol is concentration under reduced pressure and freeze-drying, but the effect of freeze-drying on the removal of methanol is not obvious, a...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, preparation low-acid water-soluble Ginkgo biloba extract

[0039]Take 2000 grams of fat-soluble ginkgo biloba extract, add 15 liters (1500 ml) of 22% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention.

[0040] Filtrate A is placed in a decompression tank for decompression, and the ethanol is recovered until there is no alcohol smell. In the process of recovering ethanol, 10 liters (10000 ml) of hot water at 52°C must be continuously added to the filtrate A, so that the weight content of the solid accounts for the solvent. The volume fraction of Ginkgo biloba was controlled at 7%, left overnight at room temperature, and filtered to obtain filtrate B, namely water-soluble Ginkgo biloba extract. Sampling was carried out to detect its total flavonoid content, lactone content and ginkgolic acid content. The detection methods were all in accordance with the provisi...

Embodiment 2

[0045] Embodiment 2, preparation low-acid water-soluble Ginkgo biloba extract

[0046] Take 2000 grams of fat-soluble ginkgo biloba extract, add 15 liters (1500 ml) of 28% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention.

[0047] Filtrate A is placed in a decompression tank for decompression, and the ethanol is recovered until there is no alcohol smell. In the process of recovering ethanol, 10 liters (10000 ml) of hot water at 52°C must be continuously added to the filtrate A, so that the weight content of the solid accounts for the solvent. The volume fraction of Ginkgo biloba was controlled at 9%, left overnight at room temperature, and filtered to obtain filtrate B, namely water-soluble Ginkgo biloba extract. Sampling was carried out to detect its total flavonoid content, lactone content and ginkgolic acid content. The detection methods were all in accordance with the provis...

Embodiment 3

[0051] Embodiment 3, preparation low-acid water-soluble Ginkgo biloba extract

[0052] Take 2000 grams of fat-soluble ginkgo biloba extract, add 15 liters (1500 ml) of 20% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention.

[0053] Put the filtrate A in a decompression tank to reduce the pressure, recover the ethanol until it has no alcohol smell, and filter to obtain the filtrate B, which is the water-soluble Ginkgo biloba extract. Sampling was carried out to detect its total flavonoid content, lactone content and ginkgolic acid content. The detection methods were all in accordance with the provisions under the Chinese Pharmacopoeia 2015 edition of Ginkgo biloba extract, high performance liquid chromatography (general rule 0512). Results: The total flavonoid content was 25%, the lactone content was 6.5%, and the ginkgolic acid content was less than 10ppm.

[0054] Put the obtai...

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Abstract

The invention discloses a method for preparing a low-acid water-soluble ginkgo biloba extract. The method for preparing the low-acid water-soluble ginkgo biloba extract provided by the invention comprises the following steps: (1) sample loading, namely loading an aqueous solution of the water-soluble ginkgo biloba extract to a ployamide absorption column; and (2) eluting with purified water after the aqueous solution of the water-soluble ginkgo biloba extract passes through the ployamide absorption column, collecting effluent and eluent of the loaded sample, thereby obtaining the low-acid water-soluble ginkgo biloba extract. According to the ginkgo biloba extract prepared by the method disclosed by the invention, process flow steps are very few, the content of ginkgolic acid in the product is less than 1ppm, the content of active ingredients in the product is high, the eluent is concentrated and dried to obtain powder, the mass fraction of general flavones is more than 24%, and the lactone content is more than 6%.

Description

technical field [0001] The invention relates to a preparation method of ginkgo leaf extract, in particular to a preparation method of low-acid water-soluble ginkgo leaf extract. Background technique [0002] Ginkgo bilobal (Ginkgo bilobal) is an ancient plant that survived on the earth during the Ice Age and is known as a "living fossil". China is the birthplace of ginkgo, and its resources account for about 70% of the world's total. In recent years, Ginkgo biloba extract and its preparations have definite curative effects on coronary heart disease, angina pectoris, brain degenerative disease, cerebral kinetic energy disorder caused by cardiovascular disease, and Alzheimer's disease, and have become the first choice for the treatment of cardiovascular and cerebrovascular diseases. [0003] China is the world's largest producer of Ginkgo biloba extract, and the industry's production capacity accounts for more than 50% of the world's total production capacity. In 2013, the o...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/10A61P9/00A61P25/28
CPCA61K36/16A61K2236/55
Inventor 孙载明孙思南
Owner ZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD
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