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Compound preparation for treating thrombosis

A technology for formulation and compound formulation, which can be applied to medical formulations without active ingredients, medical formulations containing active ingredients, blood diseases, etc., and can solve problems such as difficulty in fully exerting antithrombotic effect, short serum half-life, and component destruction. , to achieve the effect of prolonging serum half-life, enhancing immunity, and enhancing intestinal peristalsis

Inactive Publication Date: 2017-05-31
JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hirudin is easily damaged by components during use, resulting in too short a serum half-life, making it difficult to fully exert the antithrombotic effect

Method used

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  • Compound preparation for treating thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A compound preparation for treating thrombus, which is composed of the following ingredients in parts by weight: 21 parts of hirudin, 14 parts of cod liver oil, 8.5 parts of toad grass extract, 7.5 parts of apocynum extract, 7.0 parts of Prunella vulgaris extract, nightshade red 4.5 parts of gingerol, 3.5 parts of gingerol, and 2.5 parts of allicin.

[0014] As a further description of the above scheme, the extraction method of the toad grass is: crush the dried toad grass to 200 mesh fine powder, use an ethanol solution with a mass concentration of 45% to extract by conventional reflux extraction, and extract the extract by reducing Concentrate under high pressure to obtain a concentrated solution, and recover the ethanol in the concentrated solution by heating to obtain a bufo extract with a purity of 90%. contained in the extract.

[0015] As a further description of the above scheme, the extraction method of the Apocynum extract and the Prunella vulgaris extract is...

Embodiment 2

[0019] A compound preparation for treating thrombus, the preparation is composed of the following ingredients in parts by weight: 21.5 parts of hirudin, 15 parts of cod liver oil, 9.0 parts of toad grass extract, 8.0 parts of apocynum extract, 7.5 parts of Prunella vulgaris extract, eggplant red 5.0 parts of gingerol, 4.0 parts of gingerol, and 3.0 parts of allicin.

[0020] As a further description of the above scheme, the extraction method of the toad grass is: crush the dried toad grass to 220 mesh fine powder, use an ethanol solution with a mass concentration of 48% to extract by conventional reflux extraction, and extract the extract by reducing Concentrate under high pressure to obtain a concentrated solution, and recover the ethanol in the concentrated solution by heating to obtain a bufo extract with a purity of 93%. contained in the extract.

[0021] As a further description of the above scheme, the extraction method of the Apocynum extract and the Prunella vulgaris ...

Embodiment 3

[0025] A compound preparation for treating thrombus, the preparation is composed of the following ingredients in parts by weight: 22 parts of hirudin, 16 parts of cod liver oil, 9.5 parts of toad grass extract, 8.5 parts of apocynum extract, 8.0 parts of Prunella vulgaris extract, nightshade red 5.5 parts of gingerol, 4.5 parts of gingerol, and 3.5 parts of allicin.

[0026] As a further description of the above scheme, the extraction method of the toad grass is as follows: the dried toad grass is pulverized into a 240-mesh fine powder, and the ethanol solution with a mass concentration of 50% is extracted by a conventional reflux extraction method, and the extract is extracted by reducing Concentrate under pressure to obtain a concentrated solution, and recover the ethanol in the concentrated solution by heating to obtain a bufo extract with a purity of 95%. contained in the extract.

[0027] As a further description of the above scheme, the extraction method of the Apocynum...

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Abstract

The invention relates to the technical field of the traditional Chinese medicine, and discloses a compound preparation for treating thrombosis. The preparation is formed by the following components: hirudin, oleum morrhuae, Plantaginaceae Plantago major extractive, apocynum venetum extractive, selfheal extractive, lycopene, gingerol, and allicin. The compound preparation added with the rest accessories is capable of greatly prolonging the serum half-life period of the hirudin, achieving the effect of prolonging the intracorporal antithrombus effect of the hirudin, solving the defect of the hirudin for treating the thrombosis, and reducing the treatment cost.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a compound preparation for treating thrombus. Background technique [0002] A thrombus is a small block formed by blood flow on the surface of a peeled or repaired vessel in the cardiovascular system. In a variable fluid-dependent form, a thrombus consists of insoluble fibrin, deposited platelets, accumulated white blood cells, and trapped red blood cells. Nowadays, with the rapid development of fast-paced life, the incidence of thrombosis is increasing day by day. Among them, the elderly have aging blood vessels, damaged blood vessel walls, and are prone to hypertension, arteriosclerosis, and diabetes. After the vascular endothelial cells are damaged, the production of thromboplastin increases, which promotes the formation of thrombin, and the thrombin A2 also increases. At the same time, the production of anticoagulant prostacyclin decreases, which easily i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/58A61K47/46A61P7/02A61P1/08A61P37/04A61P1/14A61P1/10A61P1/12A61K36/68A61K35/60A61K31/255A61K31/122A61K31/01
CPCA61K31/01A61K31/122A61K31/255A61K35/60A61K36/24A61K36/536A61K36/68A61K38/58A61K47/46A61K2236/333A61K2300/00
Inventor 尚圣杰
Owner JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
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