Egg yolk antibody-based intestinal flora adjustment medicine

A technology of egg yolk antibody and intestinal flora, which is applied in the direction of antibodies, drug combinations, and pharmaceutical formulas, can solve problems such as poor efficacy of drugs for piglet diarrhea, and achieve the effects of promoting rebalancing, highlighting promotion prospects, and adjuvant treatment

Inactive Publication Date: 2017-06-09
TIANJIN ZHENBANG AQUACULTURE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides an intestinal flora regulating drug based on egg yolk antibody, so as to solve the technical problem of poor curative effect of the drug for treating piglet diarrhea in the prior art
[0007] Another technical problem solved by the present invention is that it is difficult to treat piglet diarrhea caused by several different pathogenic microorganisms with one drug in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A drug for regulating intestinal flora based on egg yolk antibody, including egg yolk antibody, probiotics, interferon, and azithromycin.

[0024] Its preparation method is as follows:

[0025] 1) Utilize porcine transmissible gastroenteritis virus vaccine, porcine epidemic diarrhea virus vaccine, porcine rotavirus vaccine to immunize hens, each immunized 3 times;

[0026] 2) After 5 days, take the yolk liquid of high-free eggs as raw material;

[0027] 3) Take the raw materials described in step 2), grind and crush them, then add acetate buffer solution 2.2 times the total volume of egg yolk liquid, and stir to obtain a diluent;

[0028] 4) Add 3% n-octanoic acid of its total volume to the diluent in step 3), stir, then filter and clarify, and take the supernatant as egg yolk antibody solution.

[0029] Wherein: the time interval of 3 immunizations in step 1) is 12 days; the temperature of the acetate buffer solution described in step 3) is 50° C., and the pH is 4.8;...

Embodiment 2

[0032] A drug for regulating intestinal flora based on egg yolk antibody, including egg yolk antibody, probiotics, interferon, and azithromycin.

[0033] Its preparation method is as follows:

[0034] 1) Utilize porcine transmissible gastroenteritis virus vaccine and porcine rotavirus vaccine to immunize hens, each immunized 3 times;

[0035] 2) After 9 days, take the yolk liquid of high-free eggs as raw material;

[0036] 3) Take the raw materials described in step 2), grind and crush them, then add acetate buffer solution 2.8 times the total volume of egg yolk liquid, and stir to obtain a diluent;

[0037] 4) Add 5% n-octanoic acid of its total volume to the diluent described in step 3), stir, then filter and clarify, and take the supernatant as egg yolk antibody solution.

[0038] Among them: the time interval of 3 immunizations in step 1) is 16 days; the temperature of the acetate buffer solution in step 3) is 56 ° C, and the pH is 5.2; the filtration described in step 4...

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PUM

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Abstract

The invention provides a drug for regulating intestinal flora based on egg yolk antibody. The technical solution innovatively uses egg yolk antibody, probiotics, interferon, and azithromycin in combination to prevent or treat piglet diarrhea. The dosage form can be selected Oral or injection. The medicament of the present invention can activate complement in immune response and neutralize various toxins by administering IgG antibody to piglets, so as to prevent or treat pathogenic microorganisms that cause diarrhea. The administration of probiotics can intervene in the gastrointestinal flora and promote the rebalancing of the gastrointestinal flora in patients, thereby assisting treatment. The present invention achieves outstanding technical effects with innovative technical concepts, has remarkable curative effect and is easy to prepare, so it has outstanding promotional prospects.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to a drug for regulating intestinal flora based on yolk antibody. Background technique [0002] Because the immune system of piglets is not yet fully developed and their ability to resist pathogenic microorganisms is weak, diarrhea is prone to occur. There are various causes of diarrhea, which can be divided into bacterial diarrhea, viral diarrhea, parasitic diarrhea and non-disease diarrhea according to the different causes. [0003] Among them, the pathogenic microorganisms of bacterial diarrhea include Clostridium welchii type C, Escherichia coli, Treponema suis, Salmonella, etc., which can cause red scour of piglets, pullorum of piglets, yellow scour of piglets, paratyphoid fever of piglets and other diseases and then cause diarrhea; viral diarrhea The pathogenic microorganisms mainly include porcine epidemic diarrhea virus (PEDV), porcine transmissible g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61P1/12A61P1/00A61K38/21A61K35/741A61K31/7052
CPCA61K39/42A61K31/7052A61K35/741A61K38/21
Inventor 季延滨李涛侯继明
Owner TIANJIN ZHENBANG AQUACULTURE
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