Application of lta Gene Single Nucleotide Polymorphism rs2009658 in Detection of Tuberculosis Susceptibility

A single nucleotide polymorphism, nucleotide technology, applied in the field of biomedicine, can solve problems such as unclear relationship

Active Publication Date: 2019-08-09
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although M. tuberculosis SNP research has achieved world-renowned achievements in methodology and genomics, the relationship between many SNPs and the risk of tuberculosis infection is still poorly understood, especially the relationship between SNPs in LTA and TNF genes and the risk of tuberculosis. The relationship between the

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  • Application of lta Gene Single Nucleotide Polymorphism rs2009658 in Detection of Tuberculosis Susceptibility
  • Application of lta Gene Single Nucleotide Polymorphism rs2009658 in Detection of Tuberculosis Susceptibility
  • Application of lta Gene Single Nucleotide Polymorphism rs2009658 in Detection of Tuberculosis Susceptibility

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Embodiment 1

[0041] Example 1. Application of LTA Gene Single Nucleotide Polymorphism rs2009658 in Detection of Tuberculosis Susceptibility

[0042] 1. Patients and groups

[0043] The case-control study involved in the present invention selects 2039 cases of confirmed cases admitted to the No. 309 Hospital of the People's Liberation Army altogether, and is divided into two groups: (1) tuberculosis group: patients who are admitted to the Institute of Tuberculosis of the whole army are clinically treated by imaging studies, experiments 1032 cases of active tuberculosis patients were confirmed by laboratory examination and anti-tuberculosis treatment, including 605 males and 427 females, with an average age of (39.30±19.29) years old. Including pulmonary tuberculosis, tuberculous pleurisy, tuberculous pericarditis, tuberculous meningitis, tuberculous peritonitis, urinary system tuberculosis, bone and joint tuberculosis, lymph node tuberculosis, etc. (2) Non-tuberculosis control group: 1007 ...

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Abstract

The invention discloses application of LTA (Lymphotoxin Alpha) gene single nucleotide polymorphism rs2009658 to detection of tuberculosis (TB) susceptibility. The application provided by the invention refers to preparation of a product for evaluation or assistance in assessing TB-suffering risks of a person to be detected by substances for detecting the single nucleotide polymorphism of rs2009658 loci, or preparation of a product for diagnosis or auxiliary diagnosis on whether the person to be detected suffers from TB or not. The inventor of the invention finds that a significant correlation occurs between gene polymorphism of LTA gene SNP-rs2009658 loci and the TB suffering risks through case control studies of Chinese Han populations. The populations with LTA-rs2009658GC genotypes and LTA-TNF 'GGCCG' haplotypes are at higher onset risks for mycobacterium tuberculosis infection. The invention provides a new insight into the association between the inflammatory and immune-related genes SNP and the susceptibility to TB, and is of great values in the screening and prevention of TB susceptibility genes.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of LTA gene single nucleotide polymorphism rs2009658 in detecting tuberculosis susceptibility, in particular to the application of LTA gene rs2009658 site marker in the screening and evaluation of crowd susceptibility to tuberculosis. Background technique [0002] Tuberculosis (TB) is a global disease that seriously threatens human health, and it has become one of the three major infectious diseases killers of human beings. The World Health Organization's global tuberculosis report pointed out that about 1 / 3 of the people are infected by Mycobacterium tuberculosis, and only 10% of the infected people get sick. This means that whether tuberculosis infection occurs is closely related to the interaction between host and pathogen, environment, genetics and so on. Recently, many studies have demonstrated that TB risk is closely related to polymorphisms in genes related to the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 吴雪琼龚文平张俊仙安慧茹梁艳阳幼荣
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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