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Antimicrobial compound and application thereof

An antimicrobial and composition technology, applied in the direction of application, biocide, biochemical equipment and methods, etc., can solve the problems of strong microbial resistance, poor safety, and poor activity of antimicrobial agents, and achieve strong antimicrobial efficacy , short contact time and high antibacterial rate

Inactive Publication Date: 2017-06-13
BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of existing antimicrobial agents such as poor activity, strong microbial drug resistance, and poor safety, the present invention proposes an antimicrobial composition

Method used

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  • Antimicrobial compound and application thereof
  • Antimicrobial compound and application thereof
  • Antimicrobial compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: A hydrogel combining trypsin and lysozyme.

[0044] Trypsin was purchased from Shaanxi Yuantai Biotechnology Co., Ltd., and lysozyme was purchased from Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. Trypsin and lysozyme are composed of the following components: 200 mg of lysozyme and 300 mg of trypsin, which are added to the gel matrix and fully dissolved to form a hydrogel. Bacteriostatic tests were performed using the gels of the present invention.

[0045] The gel of the present invention has the effect on Salmonella enterica, Staphylococcus aureus and Escherichia coli for 2, 5, 10 and 20 minutes. The results are shown in Table 1.

[0046] Table 1:

[0047]

[0048] The test results show that the combined gel of trypsin and lysozyme has a strong inhibitory effect on Salmonella enterica, Staphylococcus aureus and Escherichia coli.

Embodiment 2

[0049] Example 2: A combination of trypsin and lysozyme spray.

[0050] Trypsin was purchased from Shaanxi Yuantai Biotechnology Co., Ltd., and lysozyme was purchased from Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. Trypsin and lysozyme consist of the following components: 200mg of lysozyme and 300mg of trypsin, which are fully dissolved in deionized water to form a spray. The antibacterial test was carried out using the spray of the present invention.

[0051] The spray of the present invention has effects on Candida albicans, aflatoxin and Pythium for 2, 5, 10 and 20 minutes. The results are shown in Table 2.

[0052] Table 2:

[0053]

[0054] The test results showed that trypsin and lysozyme composition spray had strong inhibitory effect on Candida albicans, aflatoxin and Pythium.

Embodiment 3

[0055] Example 3: An emulsion of trypsin combined with lysozyme.

[0056] Trypsin was purchased from Shaanxi Yuantai Biotechnology Co., Ltd., and lysozyme was purchased from Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. Trypsin and lysozyme consist of the following components: 200 mg of lysozyme and 300 mg of trypsin, which are fully dissolved by adding an emulsifier to form an emulsion. Bacteriostatic tests were performed using the emulsions of the present invention.

[0057] The gel of the present invention has the effect of 2, 5, 10, 20 minutes on enterovirus, rotavirus and human coronavirus, and the results are shown in Table 3.

[0058] table 3:

[0059]

[0060] The test results show that the combined emulsion of trypsin and lysozyme has a strong inhibitory effect on enterovirus, rotavirus and human coronavirus.

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PUM

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Abstract

The invention relates to an antimicrobial compound and an application thereof. The antimicrobial compound comprises two or more synergic combined components as active ingredients and optionally comprises other carriers, excipient or auxiliary materials. The antimicrobial compound composed of trypsin and lysozyme provided by the invention has ultrahigh antimicrobial effect; the microorganism tolerance is poor; two active substances are coordinated with each other for effectively restraining various microorganisms; the contact time for achieving the antimicrobial effect is short; the antibacterial rate is high; the antimicrobial compound is free from toxic or side effect and can be applied to human body, animals and other various devices and environments.

Description

technical field [0001] The present invention relates to antimicrobial compositions and their use. Background technique [0002] Pathogenic microorganisms including, for example, bacteria, viruses and fungi are responsible for a wide range of human diseases ranging from minor ailments such as upper and lower respiratory tract infections to potentially fatal infections such as listeriosis. [0003] Over the past 100 years, major advances have been made in the fight against diseases caused by pathogenic microorganisms, and a large number of pharmaceutical and non-pharmaceutical agents have been developed for treatment. For example, in the field of pharmacy, antibiotic agents can be used to treat bacterial infections in humans, while chemical-based agents can be used for external treatments (e.g., on hard surfaces) to prevent contamination and transmission to humans, such as Listeria in ready-to-eat Situation in a meat and poultry processing plant. [0004] Although agents hav...

Claims

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Application Information

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IPC IPC(8): A61K38/48A01N63/00A01P1/00A01P3/00A61P31/04A61P31/10A61P31/12A61L9/01A61K38/47A61L101/54
CPCA61K38/47A61K38/4826A61L9/01A01N63/00C12Y304/21004A01N2300/00A61K2300/00Y02A50/30
Inventor 高敏
Owner BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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