Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

A technology for rheumatoid and arthritis, which is applied in the field of traditional Chinese medicine for treating rheumatoid arthritis and its preparation, which can solve the problems of large toxic and side effects, unsatisfactory treatment effect, and many adverse reactions, achieve good curative effect, and enhance self-immunity , no toxic side effects

Inactive Publication Date: 2017-06-16

YANTAI BOHAI PHARMA GROUP

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AI-Extracted Technical Summary

Problems solved by technology

There are problems such as large toxic side effects and many adverse reactions in western medicine treatment, and t...

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Abstract

The invention relates to a traditional Chinese medicine used for treating rheumatoid arthritis, and a preparation method thereof, and belongs to the field of pharmacy. The traditional Chinese medicine used for treating rheumatoid arthritis is composed of radix gentianae macrophyllae, rhizoma atractylodis, coix seed, rhizoma dioscoreae nipponicae, polygonum cuspidatum, caulis sargentodoxae, Chinese starjasmine stem, cassia twig, Chinese angelica, ligusticum wallichii, ramulus mori, and licorice. The preparation method comprises following steps: the above traditional Chinese medicine raw materials are smashed, and accessory materials are added so as to obtain a related preparation, or water extraction, condensation, and drying are carried out so as to obtain a related preparation; or cassia twig, Chinese angelica, and ligusticum wallichii are subjected to volatile oil extraction and beta-cyclodextrin inclusion, and an obtained residue and the left medicine raw materials are mixed, and are subjected to water extraction, condensation, drying, and mixing with an obtained inclusion compound so as to obtain a related preparation. The traditional Chinese medicine is prepared from the pure traditional Chinese medicine raw materials; no toxic or side effect is caused; no adverse effect is caused after eating; the traditional Chinese medicine is capable of expelling wind-damp and dredging main and collateral channels, and possesses excellent curative effect on rheumatoid arthritis.

Application Domain

AntipyreticAnalgesics +5

Technology Topic

POLYGONUM CUSPIDATUMLigusticum chuanxiong +11

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Examples

Experimental program(3)

Example Embodiment

[0009] Example 1

[0010] Prescription: 20 parts of Gentiana, 20 parts of Cangzhu, 20 parts of Coix Seed, 20 parts of Dioscorea nigra, 15 parts of Polygonum cuspidatum, 15 parts of Sargentodoxa cuneata, 20 parts of Trachelospermi Caulis, 15 parts of Guizhi, 15 parts of Angelica sinensis, 15 parts of Chuanxiong, 15 parts of Mulberry 15 parts, 10 parts licorice.

[0011] Preparation:

[0012] Step 1: Weigh the above twelve Chinese medicines according to the prescription ratio, crush them into fine powder, pass through a 200-mesh sieve, and mix well;

[0013] The second step: adding an appropriate amount of dextrin, making it into granules or drying it into capsules or pressing into tablets.

[0014] Although the dosage forms of the medicaments of this example are different, because they have the same active ingredients, the curative effects of different dosage forms are roughly the same. Only the experimental data of the capsule prepared in Example 1 is reported.

[0015] The clinical effect of treating rheumatoid arthritis:

[0016] The treatment group took capsules, and the control group took Zhuifeng Huoluo pills. Treatment method: treatment group: oral administration of this capsule, 3 capsules each time, 2 times a day; control group: oral administration of Zhuifeng Huoluo pills, 1 pill each time, 2 times a day. 3 months is a course of treatment. The clinical data are shown in Table 1.

[0017] Table 1 Comparison of curative effect of rheumatoid arthritis

[0018]

[0019] The total number of patients in the treatment group was 92 cases, of which 4 cases were clinically cured, 36 cases were markedly effective, 40 cases were improved, 12 cases were ineffective, and the total effective rate was 87.0%; the control group had 68 cases, of which 1 case was clinically cured, 16 cases were markedly effective, and 25 cases improved. 26 cases were ineffective, with a total effective rate of 61.8%; the treatment group was better than the control group, and there was a significant difference between the two.

Example Embodiment

[0020] Example 2

[0021] Same prescription as in Example 1

[0022] Preparation:

[0023] The first step: add water to decoct the above-mentioned twelve-flavored Chinese medicine twice, add 10 times the amount of water for the first time, heat and decoct for 2 hours, filter, and use the filtrate for later use;

[0024] Step 2: Add 8 times the amount of water for the second time, heat and cook for 1 hour, filter, and reserve the filtrate;

[0025] The third step: Combine the above-mentioned filtrate, concentrate to a relative density of 1.25-1.30 (measured at 50°C), add an appropriate amount of dextrin, vacuum dry at 70°C, pulverize, granulate with 95% ethanol, dry at 90°C, and compress into tablets. Or made into capsules, or made into granules.

[0026] Although the dosage forms of the medicaments of this example are different, because they have the same active ingredients, the curative effects of different dosage forms are roughly the same. Only the experimental data of the capsules prepared in Example 2 are reported.

[0027] The clinical effect of treating rheumatoid arthritis:

[0028] The treatment group took capsules, and the control group took Zhuifeng Huoluo pills. Treatment method: treatment group: oral administration of this capsule, 3 capsules each time, 2 times a day; control group: oral administration of Zhuifeng Huoluo pills, 1 pill each time, 2 times a day. 3 months is a course of treatment. The clinical data are shown in Table 2.

[0029] Table 2 Comparison of curative effect of rheumatoid arthritis

[0030]

[0031] The total number of patients in the treatment group was 60 cases, of which 2 cases were clinically cured, 24 cases were markedly effective, 26 cases improved, 8 cases were ineffective, and the total effective rate was 86.7%; the control group had 60 cases, of which 0 cases were clinically cured, 14 cases were markedly effective, and 27 cases improved. 19 cases were ineffective, the total effective rate was 68.3%; there was a significant difference between the two.

Example Embodiment

[0032] Example 3

[0033] Same prescription as in Example 1

[0034] Preparation:

[0035] The first step: add 10 times the amount of Guizhi, Angelica and Chuanxiong to extract with steam distillation for 5 hours, collect the volatile oil, and use it for later use; filter the medicinal solution and use the filtrate for use; mix the medicinal residue with other medicinal materials and prepare for extraction;

[0036] Step 2: Add 10 times the amount of water to the medicinal materials, heat and decoc for 2 hours, filter, and then use the filtrate for use; wrap the extracted volatile oil with β-cyclodextrin (β-CD) for use; the specific method for incorporation is as follows: :

[0037] 1. Take spare volatile oil, dilute it with an equal volume of 95% ethanol, and set aside

[0038] 2. Weigh 8 times the amount of β-CD equivalent to the volatile oil, add water at the ratio of β-CD: water = 1g: 20ml, dissolve with slight heat, and keep the temperature of the solution at 35°C. Slowly drip into the ethanol solution of the volatile oil, continue to stir for 3 hours after the addition is complete, put it at 2~4℃, and let it stand for 12~24h

[0039] 3. Suction filtration, dry the filter cake at 40~45℃, grind finely, and sieve to obtain

[0040] The third step: add 8 times of water to the dregs and continue to extract for 1 hour, filter, and use the filtrate for later use;

[0041] Step 4: Combine the filtrate from the first, second, and third steps, concentrate to a relative density of 1.25-1.30 (measured at 50°C), add appropriate amount of dextrin, mix well, dry under reduced pressure at 70°C, crush into fine powder, add volatile oil β -Cyclodextrin inclusion compound, mix well, granulate with 90% ethanol, dry, press into tablets, or make capsules, or make granules.

[0042] Although the dosage forms of the medicaments of this example are different, because they have the same active ingredients, the curative effects of different dosage forms are roughly the same. Only the experimental data of the capsule prepared in Example 3 is reported.

[0043] The clinical effect of treating rheumatoid arthritis:

[0044] The treatment group took capsules, and the control group took Zhuifeng Huoluo pills. Treatment method: treatment group: oral administration of this capsule, 3 capsules each time, 2 times a day; control group: oral administration of Zhuifeng Huoluo pills, 1 pill each time, 2 times a day. 3 months is a course of treatment. The clinical data are shown in Table 3.

[0045] Table 3 Comparison of curative effect of rheumatoid arthritis

[0046]

[0047] The total number of patients in the treatment group was 68, of which 12 were clinically cured, 28 were markedly effective, 21 were improved, 7 were ineffective, and the total effective rate was 89.7%; the control group had 56 patients, including 1 clinically cured, 14 markedly effective, and 17 improved. 24 cases were ineffective, the total effective rate was 59.3%; there was a significant difference between the two.

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Classification and recommendation of technical efficacy words

No side effects
Improve autoimmunity

Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

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Description & Claims & Application Information

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