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Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

A technology for rheumatoid and arthritis, which is applied in the field of traditional Chinese medicine for treating rheumatoid arthritis and its preparation, which can solve the problems of large toxic and side effects, unsatisfactory treatment effect, and many adverse reactions, achieve good curative effect, and enhance self-immunity , no toxic side effects

Inactive Publication Date: 2017-06-16
YANTAI BOHAI PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are problems such as large toxic side effects and many adverse reactions in western medicine treatment, and there are also problems such as unacceptable for patients and unsatisfactory treatment effect in surgical treatment.

Method used

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  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof
  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof
  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Prescription: 20 parts of Gentiana, 20 parts of Cangzhu, 20 parts of Coix Seed, 20 parts of Chuanshanlong, 15 parts of Polygonum cuspidatum, 15 parts of Daxueteng, 20 parts of Tengshiteng, 15 parts of Guizhi, 15 parts of Angelica, 15 parts of Chuanxiong, Morangzhi 15 parts, 10 parts of licorice.

[0011] Preparation:

[0012] The first step: weigh the above twelve traditional Chinese medicines according to the prescription ratio, grind them into fine powder, pass through a 200-mesh sieve, and mix well;

[0013] Step 2: add an appropriate amount of dextrin, make it into granules or dry it into capsules or compress into tablets.

[0014] Although the dosage forms of the medicaments in this example are different, because they have the same active ingredient, the curative effects of different dosage forms are roughly the same, and only the experimental data of the capsules prepared in Example 1 are reported.

[0015] Clinical efficacy in the treatment of rheumatoid arthri...

Embodiment 2

[0021] Prescription is the same as embodiment 1

[0022] Preparation:

[0023] The first step: decoct the above twelve traditional Chinese medicines with water twice, add 10 times the amount of water for the first time, heat and decoct for 2 hours, filter, and set aside the filtrate;

[0024] Step 2: Add 8 times the amount of water for the second time, heat and decoct for 1 hour, filter, and set aside the filtrate;

[0025] Step 3: Combine the above filtrates, concentrate to a relative density of 1.25-1.30 (measured at 50°C), add an appropriate amount of dextrin, vacuum-dry at 70°C, pulverize, granulate with 95% ethanol, dry at 90°C, and press into tablets. Or made into capsules, or made into granules.

[0026] Although the dosage forms of the medicaments in this example are different, because they have the same active ingredient, the curative effects of different dosage forms are roughly the same, and only the experimental data of the capsules prepared in Example 2 are repo...

Embodiment 3

[0033] Prescription is the same as embodiment 1

[0034] Preparation:

[0035] Step 1: extract cassia twig, angelica, and chuanxiong with 10 times the amount of water by steam distillation for 5 hours, collect the volatile oil, and set aside; filter the liquid medicine, and set aside the filtrate; mix the dregs with other medicinal materials, and prepare for extraction;

[0036] Step 2: Add 10 times the amount of water to the medicinal materials, heat and decoct for 2 hours, filter, and use the filtrate for later use; wrap the extracted volatile oil with β-cyclodextrin (β-CD) for later use; the specific method of inclusion is as follows: :

[0037] 1. Take the spare volatile oil, dilute it with an equal volume of 95% ethanol, and set aside

[0038] 2. Weigh again β-CD equivalent to 8 times the amount of volatile oil, add water according to the ratio of β-CD:water=1g:20ml, heat slightly to dissolve, and keep the solution temperature at 35°C. Slowly drop into the ethanol solu...

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Abstract

The invention relates to a traditional Chinese medicine used for treating rheumatoid arthritis, and a preparation method thereof, and belongs to the field of pharmacy. The traditional Chinese medicine used for treating rheumatoid arthritis is composed of radix gentianae macrophyllae, rhizoma atractylodis, coix seed, rhizoma dioscoreae nipponicae, polygonum cuspidatum, caulis sargentodoxae, Chinese starjasmine stem, cassia twig, Chinese angelica, ligusticum wallichii, ramulus mori, and licorice. The preparation method comprises following steps: the above traditional Chinese medicine raw materials are smashed, and accessory materials are added so as to obtain a related preparation, or water extraction, condensation, and drying are carried out so as to obtain a related preparation; or cassia twig, Chinese angelica, and ligusticum wallichii are subjected to volatile oil extraction and beta-cyclodextrin inclusion, and an obtained residue and the left medicine raw materials are mixed, and are subjected to water extraction, condensation, drying, and mixing with an obtained inclusion compound so as to obtain a related preparation. The traditional Chinese medicine is prepared from the pure traditional Chinese medicine raw materials; no toxic or side effect is caused; no adverse effect is caused after eating; the traditional Chinese medicine is capable of expelling wind-damp and dredging main and collateral channels, and possesses excellent curative effect on rheumatoid arthritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Traditional Chinese medicine believes that rheumatoid arthritis is a type of arthralgia, which refers to the invasion of the human body by wind, cold, dampness, heat and other exogenous evils, blocking the meridians, and poor circulation of Qi and blood, resulting in muscle and joint pain, poor flexion and extension, and joint swelling. The main clinical manifestations of the disease. The dialectical theory and treatment of rheumatoid medicine in the motherland are always evil, excess and positive deficiency. The active stage is mostly based on evil and excess, and the treatment is mainly to eliminate pathogenic factors; The treatment of positive deficiency should strengthen the positive and eliminate the pathogenic factors; at present, western medicine usually uses hormones or anti-inflammatory drug...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P19/02A61P29/00
CPCA61K36/51A61K9/1652A61K9/2059A61K36/185A61K36/232A61K36/236A61K36/24A61K36/284A61K36/484A61K36/54A61K36/605A61K36/704A61K36/8945A61K36/8994A61K2236/331A61K2236/39A61K2236/51
Inventor 车洪勇王继鹏高浩学
Owner YANTAI BOHAI PHARMA GROUP
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