Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

A technology for rheumatoid and arthritis, which is applied in the field of traditional Chinese medicine for treating rheumatoid arthritis and its preparation, which can solve the problems of large toxic and side effects, unsatisfactory treatment effect, and many adverse reactions, achieve good curative effect, and enhance self-immunity , no toxic side effects

Inactive Publication Date: 2017-06-16
YANTAI BOHAI PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are problems such as large toxic side effects and many adverse reactions in western medicine treatment, and t

Method used

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  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof
  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof
  • Traditional Chinese medicine used for treating rheumatoid arthritis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0009] Example 1

[0010] Prescription: 20 parts of Gentiana, 20 parts of Cangzhu, 20 parts of Coix Seed, 20 parts of Dioscorea nigra, 15 parts of Polygonum cuspidatum, 15 parts of Sargentodoxa cuneata, 20 parts of Trachelospermi Caulis, 15 parts of Guizhi, 15 parts of Angelica sinensis, 15 parts of Chuanxiong, 15 parts of Mulberry 15 parts, 10 parts licorice.

[0011] Preparation:

[0012] Step 1: Weigh the above twelve Chinese medicines according to the prescription ratio, crush them into fine powder, pass through a 200-mesh sieve, and mix well;

[0013] The second step: adding an appropriate amount of dextrin, making it into granules or drying it into capsules or pressing into tablets.

[0014] Although the dosage forms of the medicaments of this example are different, because they have the same active ingredients, the curative effects of different dosage forms are roughly the same. Only the experimental data of the capsule prepared in Example 1 is reported.

[0015] The clinical ef...

Example Embodiment

[0020] Example 2

[0021] Same prescription as in Example 1

[0022] Preparation:

[0023] The first step: add water to decoct the above-mentioned twelve-flavored Chinese medicine twice, add 10 times the amount of water for the first time, heat and decoct for 2 hours, filter, and use the filtrate for later use;

[0024] Step 2: Add 8 times the amount of water for the second time, heat and cook for 1 hour, filter, and reserve the filtrate;

[0025] The third step: Combine the above-mentioned filtrate, concentrate to a relative density of 1.25-1.30 (measured at 50°C), add an appropriate amount of dextrin, vacuum dry at 70°C, pulverize, granulate with 95% ethanol, dry at 90°C, and compress into tablets. Or made into capsules, or made into granules.

[0026] Although the dosage forms of the medicaments of this example are different, because they have the same active ingredients, the curative effects of different dosage forms are roughly the same. Only the experimental data of the capsules ...

Example Embodiment

[0032] Example 3

[0033] Same prescription as in Example 1

[0034] Preparation:

[0035] The first step: add 10 times the amount of Guizhi, Angelica and Chuanxiong to extract with steam distillation for 5 hours, collect the volatile oil, and use it for later use; filter the medicinal solution and use the filtrate for use; mix the medicinal residue with other medicinal materials and prepare for extraction;

[0036] Step 2: Add 10 times the amount of water to the medicinal materials, heat and decoc for 2 hours, filter, and then use the filtrate for use; wrap the extracted volatile oil with β-cyclodextrin (β-CD) for use; the specific method for incorporation is as follows: :

[0037] 1. Take spare volatile oil, dilute it with an equal volume of 95% ethanol, and set aside

[0038] 2. Weigh 8 times the amount of β-CD equivalent to the volatile oil, add water at the ratio of β-CD: water = 1g: 20ml, dissolve with slight heat, and keep the temperature of the solution at 35°C. Slowly drip in...

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Abstract

The invention relates to a traditional Chinese medicine used for treating rheumatoid arthritis, and a preparation method thereof, and belongs to the field of pharmacy. The traditional Chinese medicine used for treating rheumatoid arthritis is composed of radix gentianae macrophyllae, rhizoma atractylodis, coix seed, rhizoma dioscoreae nipponicae, polygonum cuspidatum, caulis sargentodoxae, Chinese starjasmine stem, cassia twig, Chinese angelica, ligusticum wallichii, ramulus mori, and licorice. The preparation method comprises following steps: the above traditional Chinese medicine raw materials are smashed, and accessory materials are added so as to obtain a related preparation, or water extraction, condensation, and drying are carried out so as to obtain a related preparation; or cassia twig, Chinese angelica, and ligusticum wallichii are subjected to volatile oil extraction and beta-cyclodextrin inclusion, and an obtained residue and the left medicine raw materials are mixed, and are subjected to water extraction, condensation, drying, and mixing with an obtained inclusion compound so as to obtain a related preparation. The traditional Chinese medicine is prepared from the pure traditional Chinese medicine raw materials; no toxic or side effect is caused; no adverse effect is caused after eating; the traditional Chinese medicine is capable of expelling wind-damp and dredging main and collateral channels, and possesses excellent curative effect on rheumatoid arthritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Traditional Chinese medicine believes that rheumatoid arthritis is a type of arthralgia, which refers to the invasion of the human body by wind, cold, dampness, heat and other exogenous evils, blocking the meridians, and poor circulation of Qi and blood, resulting in muscle and joint pain, poor flexion and extension, and joint swelling. The main clinical manifestations of the disease. The dialectical theory and treatment of rheumatoid medicine in the motherland are always evil, excess and positive deficiency. The active stage is mostly based on evil and excess, and the treatment is mainly to eliminate pathogenic factors; The treatment of positive deficiency should strengthen the positive and eliminate the pathogenic factors; at present, western medicine usually uses hormones or anti-inflammatory drug...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P19/02A61P29/00
CPCA61K36/51A61K9/1652A61K9/2059A61K36/185A61K36/232A61K36/236A61K36/24A61K36/284A61K36/484A61K36/54A61K36/605A61K36/704A61K36/8945A61K36/8994A61K2236/331A61K2236/39A61K2236/51
Inventor 车洪勇王继鹏高浩学
Owner YANTAI BOHAI PHARMA GROUP
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