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Application of Aidi preparation in preparation of medicine for treating malignant trophoblastic tumor

A trophoblast, tumor drug technology, applied in anti-tumor drugs, drug combinations, drug delivery, etc., can solve the problems of high toxicity and side effects, poor prognosis and quality of life

Active Publication Date: 2021-01-05
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key to determining the curative effect is the choice of chemotherapy drugs, but the current chemotherapy drugs often have the problems of high toxicity and side effects, and poor prognosis and quality of life

Method used

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  • Application of Aidi preparation in preparation of medicine for treating malignant trophoblastic tumor
  • Application of Aidi preparation in preparation of medicine for treating malignant trophoblastic tumor
  • Application of Aidi preparation in preparation of medicine for treating malignant trophoblastic tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077]Example 1: Preparation of Aidi injection (low component)

[0078]Ingredients: Cantharidin 4g, Ginseng 200g, Astragalus 450g, Acanthopanax 900g

[0079]Preparation method: take Cantharidum medicinal material, crush, extract 5 times with 400ml 100% ethanol under heating and reflux, extraction time respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, medicine residue for use, and use 4% for extract Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, dilute to 1000ml with water, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, centrifuge and filter, supernatant with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, ready for use; take ginseng slices, heat reflux with 480ml of 60% ethanol, extract for 3h, filter, and reserve for use. The extract is decompressed to recover the ethanol, and the concentrate is added with water to a volume of 150ml, and the hole is topped. Adsorption resin, add water to elute 5 times t...

Embodiment 2

[0080]Example 2: Preparation of Aidi injection

[0081]Ingredients: Cantharidin 5g, Ginseng 250g, Astragalus 500g, Acanthopanax 1000g

[0082]Preparation method: take Cantharidum medicinal material, crush, extract 5 times with 400ml 100% ethanol under heating and reflux, extraction time respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, medicine residue for use, and use 4% for extract Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, dilute to 1000ml with water, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, centrifuge and filter, supernatant with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, ready for use; take ginseng slices, heat reflux with 480ml of 60% ethanol, extract for 3h, filter, and reserve for use. The extract is decompressed to recover the ethanol, and the concentrate is added with water to a volume of 150ml, and the hole is topped. Adsorption resin, add water to elute 5 times the column volum...

Embodiment 3

[0083]Example 3: Preparation of Aidi injection

[0084]Ingredients: Cantharidin 10g, Ginseng 300g, Astragalus 750g, Acanthopanax 1250g

[0085]Preparation method: take Cantharidum medicinal material, crush, extract 5 times with 400ml 100% ethanol under heating and reflux, extraction time respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, medicine residue for use, and use 4% for extract Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, dilute to 1000ml with water, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, centrifuge and filter, supernatant with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, ready for use; take ginseng slices, heat reflux with 480ml of 60% ethanol, extract for 3h, filter, and reserve for use. The extract is decompressed to recover the ethanol, and the concentrate is added with water to a volume of 150ml, and the hole is topped. Adsorption resin, add water to elute 5 times the column volu...

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Abstract

The invention discloses the application of an Aidi preparation in the preparation of medicines for treating malignant trophoblastic tumors. The Aidi preparation of the invention is composed of mylabris, ginseng, astragalus and Acanthopanax four herbs; the Aidi preparation of the invention has relatively It has a strong effect on treating malignant trophoblastic tumors, has significant drug efficacy, has few side effects, and is safer for clinical use. It provides a new therapeutic approach for the treatment of malignant trophoblastic tumors and expands the clinical application of Aidi preparations.

Description

Technical field[0001]The invention relates to a new application of an Aidi preparation, in particular to the application of an Aidi preparation in the preparation of a medicine for treating malignant trophoblastic tumors.Background technique[0002]Malignant trophoblastoma is the malignant transformation of embryonic trophoblast cells. Such tumors include invasive mole, choriocarcinoma, and placental trophoblastic tumors, while choriocarcinoma includes gestational choriocarcinoma and non-pregnant choriocarcinoma, non-pregnant Choriocarcinoma is rare, but it can occur in the retromediastinum, ovaries, lungs, esophagus, stomach, liver, pelvic and abdominal cavity. The cause of trophoblast is unclear, which may be related to malnutrition (especially lack of high-quality animal protein diet), viral infection, ovarian dysfunction and egg abnormalities, chromosomal abnormalities, immune function abnormalities, race, geography, climate and environmental influences. Malignant trophoblastoma i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/481A61P35/00A61K35/64
CPCA61K9/0019A61K9/08A61K36/254A61K36/258A61K36/481A61K35/63A61K2300/00
Inventor 窦啟玲隋东虎张圣贵
Owner GUIZHOU YIBAI PHARMA CO LTD