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Fibroin tissue repairing material containing fructus kochiae

A silk protein and tissue repair technology, applied in the field of silk protein tissue repair materials, can solve the problems of difficult to achieve blood vessel formation and tissue repair functions, and achieve the effect of improving tissue repair function, increasing specific surface area, and improving tissue repair ability.

Inactive Publication Date: 2017-07-07
WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing technologies are pure silk fibroin materials, and it is difficult to achieve the ideal function of promoting angiogenesis and tissue repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A fibroin tissue repair material containing Kochia chinensis, which is a membrane-like substance containing silk protein, with an average internal pore density of 1-3000 / mm 2 , with an average pore size of 1-500 μm, and the membrane-like material contains the following raw materials in parts by weight: 70 parts of silk protein solution, 6 parts of silk protein nanofiber solution, 7 parts of Kochia chinensis extract, naprometone sustained-release microfiber Capsules 2 servings.

[0024] The Kochia scoparia extract is prepared by the following method: weigh 25 g of Kochia scoparia, pulverize it into a coarse powder, add water 10 times its weight, decoct and extract at 90-100°C for 1 hour, and suction filter to obtain a filtrate 1 Add distilled water 6 times the weight of the filter residue to the filter residue, decoct and extract at 70-80°C for 1 hour, and filter with suction to obtain filtrate 2; Concentrate under reduced pressure at 0.05-0.08 Pa to 4 times the weight ...

Embodiment 2

[0034] A fibroin tissue repair material containing Kochia chinensis, which is a membrane-like substance containing silk protein, with an average internal pore density of 1-3000 / mm 2 , with an average pore size of 1-500 μm, and the membrane-like material contains the following raw materials in parts by weight: 100 parts of silk protein solution, 9 parts of silk protein nanofiber solution, 9 parts of Kochia chinensis extract, and naprometone sustained-release microfiber Capsules 3 servings.

[0035] The Kochia scoparia extract is prepared by the following method: weigh 25 g of Kochia scoparia, pulverize it into a coarse powder, add water 10 times its weight, decoct and extract at 90-100°C for 1.5 hours, and suction filter to obtain the filtrate 1; Add distilled water 6 times the weight of the filter residue to the filter residue, decoct and extract at 70-80°C for 1.5h, and filter with suction to obtain filtrate 2; Concentrate under reduced pressure to 4 times the weight of Koch...

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PUM

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Abstract

The invention relates to a fibroin tissue repairing material containing fructus kochiae. The fibroin tissue repairing material is a membranoid substance containing fibroin; the inner average pore density is 1-3000 pieces / mm2; the average pore size is 1-500mum. The membranoid substance contains the following raw materials in parts by weight: 70-100 parts of fibroin solution, 6-9 parts of fibroin nano-fiber solution, 7-9 parts of fructus kochiae extracting solution and 2-3 parts of nabumetone slow-release microcapsule. The invention relates to the field of biological material and fibroin. The macro-tissue and complex organ can have a biological function only when the biological material for repairing the damaged macro-tissue and complex organ has the capacity of boosting vascularization. Most materials in the prior art are pure silk fibroin repairing materials and are difficult to achieve ideal vascularization and tissue repairing functions, but the tissue repairing material prepared according to the invention has a better tissue repairing effect.

Description

technical field [0001] The invention relates to the field of biological materials and silk protein, in particular to a silk protein tissue repair material containing Kochia chinensis. Background technique [0002] Tissue engineering technology is a new method for treating tissue and organ defects, which consists of biological scaffolds, cells, growth factors and other elements. Among them, biological scaffolds play an important role in tissue engineering as the physical support for cell growth, proliferation, and new tissue formation. Tissue engineering aims to restore and reconstruct the structural and functional integrity of damaged tissues or organs, but the repair of complex tissues and organs cannot be solved today. Unlike simple thin-layer tissues, large tissues and complex organs can obtain nutrients and oxygen through the diffusion of small molecules. They need to obtain nutrients and oxygen through a huge vascular system. Biomaterials for repairing damaged large t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/36A61L27/50A61L27/54A61L27/56
CPCA61L27/3637A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/216A61L2300/30A61L2300/412A61L2300/602A61L2300/622A61L2400/12A61L2430/34C08L89/00
Inventor 吴长应
Owner WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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