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Application of 3-deoxysappanchalcone in preparing medicine for preventing and treating colorectal cancer

A colorectal cancer, chalcone technology, applied in the field of medicine and chemical industry

Inactive Publication Date: 2017-07-14
CHINA-US (HENAN) HORMEL CANCER INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the malignant progression of colorectal cancer recurrence and metastasis due to chemotherapy failure is still a key clinical problem to be solved.

Method used

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  • Application of 3-deoxysappanchalcone in preparing medicine for preventing and treating colorectal cancer
  • Application of 3-deoxysappanchalcone in preparing medicine for preventing and treating colorectal cancer
  • Application of 3-deoxysappanchalcone in preparing medicine for preventing and treating colorectal cancer

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Embodiment Construction

[0022] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0023] The present invention first obtains through kinase screening experiments that 3-deoxyhematochalcone (3-DSC) can effectively target TOPK. On this basis, research on cell proliferation assays (MTT, non-anchored growth assays, cell cycle and apoptosis); drug-targeted protein binding assays; competitive binding assays between drugs and ATP; kinase assays; and drug The research on the signaling pathway and apoptosis targeting TOPK includes the research on the signaling pathway of the natural compound at different time points, etc., and finally applied to the animal experiment research.

[0024] Materials and Methods

[0025] 1 material.

[0026] 1.1 Colon cancer cell lines

[0027] The colon cancer cell lines used in the present invention are all from ATCC (including ...

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Abstract

The invention relates to an application of a natural compound 3-deoxysappanchalcone (3-DSC for short) in preparing medicine for inhibiting tumor cell proliferation. According to a cell proliferation experiment, the inhibiting effect of 3-DSC in a colorectal cancer cell line, especially in four cell lines: HCT-15, HCT-116, SW620 and DLD1 with highly expressed TOPK, is verified, therefore providing help and ground for clinically researching medicine for preventing and treating colorectal cancer.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to the antitumor activity of a compound 3-deoxyhemochalcone, which can be used to prepare drugs for the prevention and treatment of colorectal cancer, and to target colorectal cancer with the ability to promote tumor cell proliferation Drug development of TOPK protein, etc. Background technique [0002] Colorectal cancer is one of the malignant tumors of the digestive tract, and it is also the second largest malignant tumor in the gastrointestinal tract after esophageal cancer. The curative effect of colorectal cancer is certain under the comprehensive treatment strategy of surgery combined with chemotherapy and radiotherapy. improvement. However, the malignant progression of colorectal cancer recurrence and metastasis due to chemotherapy failure is still a key clinical problem to be solved. [0003] TOPK is a newly discovered serine-threonine protein kina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P35/00
CPCA61K31/12
Inventor 董子钢李美贤黄海赵冉刘雪娇崔富荣刘康栋
Owner CHINA-US (HENAN) HORMEL CANCER INST
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