A kind of iron-based material with surface patterned deposition metal and its preparation method and application

An iron-based material and surface pattern technology, applied in metal material coating process, vacuum evaporation plating, coating and other directions, can solve the problems of accelerated corrosion of iron-based materials, no disclosure, etc., to achieve accelerated corrosion and controllable corrosion rate , good biocompatibility

Inactive Publication Date: 2019-01-25
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, researchers have done a lot of research on pure iron as a degradable medical metal material, such as improving the performance of pure iron by alloying, new preparation technology, and composite materials. These iron-based materials are relatively pure Iron, which has been improved in terms of mechanical properties and corrosion properties, but there is no publication of any literature on accelerating the corrosion of iron-based materials

Method used

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  • A kind of iron-based material with surface patterned deposition metal and its preparation method and application
  • A kind of iron-based material with surface patterned deposition metal and its preparation method and application
  • A kind of iron-based material with surface patterned deposition metal and its preparation method and application

Examples

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Embodiment 1

[0028] Example 1. Preparation of iron-based materials by depositing Pt disk arrays on the surface of pure iron

[0029] The test raw materials are pure Fe (purity: 99.95wt.%) and pure Pt (purity: 99.99wt.%).

[0030] Example 1 designed and prepared two iron-based materials with the size and arrangement of Pt discs on the surface, including Φ20 μm × S5 μm (Φ20 μm means that the diameter of the Pt electrode disc is 20 μm, and S5 μm means that the distance between the two nearest adjacent Pt discs is 5 μm ) and Φ4μm×S4μm, and the Pt disk was plated on the surface of pure iron by photolithography technology and electron beam evaporation technology. The ratio of the surface area of ​​Pt disk to pure iron was 0.50265 and 0.19635, respectively.

[0031] The preparation process of the Pt disk pattern is as follows figure 1 As shown, the specific steps are as follows:

[0032] (1) Polish the pure iron sheet, on the polished pure iron sheet (Φ75×1mm 2 ) is spin-coated with a layer of...

Embodiment 2

[0036] Embodiment 2, corrosion performance

[0037]The Pt disk patterned pure iron cold cut that embodiment 1 makes is 10 * 10 * 2mm 3 block sample, and then in Hank’s simulated body fluid (NaCl 8.0g, CaCl 2 0.14g, KCl 0.4g, NaHCO 3 0.35g, glucose 1.0g, MgCl 2 ·6H 2 O 0.1g,Na 2 HPO 4 2H 2 O 0.06g, KH 2 PO 4 0.06g, MgSO 4 ·7H 2 O 0.06g was dissolved in 1L deionized water) to carry out electrochemical test and immersion test to detect the corrosion rate of the material, with unpatterned pure iron as a comparison (measured by experiment, pure iron is in the Hank's simulated body fluid with a temperature of 37 ℃ The corrosion potential of platinum is -0.699V, the corrosion potential of platinum is 0.20V, and the corrosion potential difference between platinum and iron is 0.899V).

[0038] The electrochemical parameters of the Pt disc patterned iron-based material prepared in Example 1 and the corrosion rate calculated by two detection methods are shown in Table 1. As ...

Embodiment 3

[0043] Embodiment 3, the biocompatibility of patterned iron-based material

[0044] Prepare the experimental sample according to the method in Example 1, and compare it with unpatterned pure iron. 2 ·ml -1 The standard extraction extract was used for cytotoxicity experiments of vascular smooth muscle cells VSMC and endothelial cells EA.hy-926. In addition, the sample was soaked in 10 mL of physiological saline containing 0.2 ml of diluted human blood (normal saline:human blood (volume)=5:4) for 1 hour, and the hemolysis rate of the material was tested.

[0045] The results of the cell survival rate and Pt disk patterned pure iron hemolysis rate relative to the negative control after culture are as follows: image 3 and Figure 4 shown by image 3 It can be seen that after culturing patterned iron-based materials and unpatterned pure iron extracts for 1, 2 and 4 days, the survival rate of VSMC cells decreased with the prolongation of culture time, while EA.hy-926 The cells...

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Abstract

The invention discloses an iron-based material of surface patterning deposited metal and a preparation method and application of the iron-based material. The iron-based material of the surface patterning deposited precious metal comprises an iron-based basis material and the metal which is deposited on the surface of the iron-based basis material according to a pre-designed pattern; and the corrosion potential of the metal in simulated body fluid at the temperature of 35-40 DEG C is more positive than that of iron. According to the iron-based material, the metal element is used for forming patterned modification on the surface of the iron-based basis material, galvanic corrosion is formed between a pattern and a pure iron substrate, thus, corrosion of the iron-based basis material is further accelerated, and in addition, due to the designability of the material selection of the metal pattern, the pattern shape, the pattern distribution and the pattern number, comprehensive control of corrosion of the iron-based material is achieved. According to the iron-based material of the surface patterning deposited metal and the preparation method and application of the iron-based material, the iron-based material corrosion speed is controllable, the biocompatibility is good, the material can be used for manufacturing medical implants such as cardiovascular stents, and the problem that according to a traditional inert metal stent, late thrombosis, stent-restenosis and the like are caused is solved.

Description

technical field [0001] The invention relates to an iron-based material with surface patterned deposited metal, a preparation method and application thereof, and belongs to the field of medical iron alloy materials and preparation methods thereof. Background technique [0002] At present, the widely used clinical cardiovascular stent materials are mainly metal materials, including 316L stainless steel, Ti and Ni-Ti alloys, Co-Cr alloys, Pt-Ir alloys, and metal Ta. However, these stent materials are all biologically inert materials and are non-degradable in vivo. After implantation, they will exist in the body as foreign bodies for a long time. There is a risk of vascular restenosis and late thrombosis, and long-term antiplatelet therapy is required. In view of the above reasons, the development of biodegradable vascular stent materials is the development trend of cardiovascular stents. [0003] At present, the research on degradable cardiovascular stent materials at home and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/30C23C14/04A61F2/82
CPCA61F2/82C23C14/042C23C14/30
Inventor 郑玉峰黄涛
Owner PEKING UNIV
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