Applications of anthracene ring type compounds in preparation of medicines treating AIDS

An anthracycline compound, AIDS technology, applied in the application field of medicine, can solve problems such as no anti-HIV activity of anthracycline compound, no anti-HIV activity method, etc.

Inactive Publication Date: 2017-08-15
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on methods for quickly and accurately predicting and discovering that existing drugs have anti-HIV activity in the prior art, and there are no reports that anthracyclines have high anti-HIV activity

Method used

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  • Applications of anthracene ring type compounds in preparation of medicines treating AIDS
  • Applications of anthracene ring type compounds in preparation of medicines treating AIDS
  • Applications of anthracene ring type compounds in preparation of medicines treating AIDS

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Experimental purpose: To test the anti-HIV effect of anthracyclines.

[0024] 2. Experimental materials:

[0025] Measuring Drugs and Compounds:

[0026]The samples to be tested, Daunorubicin and Epirubicin, were purchased from Dalian Meilun Biotechnology Co., Ltd. The samples to be tested, Idarubicin and Valrubicin, were purchased from Beijing Lebo Biotechnology Co., Ltd. The sample to be tested, Doxorubicin (Doxorubicin), was purchased from Beijing Lamboride Trading Co., Ltd. The positive control compound azidothymidine (3'-Azido-3'-deoxythymidine, AZT) was purchased from Sigma. The sample to be tested is dissolved in RPMI-1640 complete medium or DMSO according to solubility, the sample stock solution concentration dissolved in DMSO is 50mM, and the sample stock solution concentration dissolved in RPMI-1640 complete medium is 10mM, 5mM or 2mM ( According to the solubility), the storage conditions are: -20°C; AZT is dissolved in RPMI-1640 complete medium, steril...

Embodiment 2

[0059] The anthracycline compound mentioned in Example 1 was dissolved in sterile water for injection to dissolve, and then filtered through a sterile funnel, finely filtered, potted, and sterilized to prepare an injection.

Embodiment 3

[0061] Take the anthracycline compound mentioned in Example 1, mix it uniformly with the excipient at a weight ratio of 1:8, granulate, and compress into tablets.

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PUM

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Abstract

The invention provides applications of anthracene ring type compounds in preparation of medicines treating AIDS, especially applications of anthracene ring type compounds which are daunorubicin, doxorubicin, pharmorubicin, idarubicin and valrubicin in preparation of medicines treating AIDS. A human T lymphocyte line C8166 and an HIV-1 experimental strain that is HIV-1NL4-3 are selected to perform in-vitro cytotoxicity and anti-HIV activity experiments on the anthracene ring type compounds, wherein the cytotoxicity is detected by using an MTT colorimetric method, and the anti-HIV activity is detected by a symplasm inhibiting test method and an HIV-1p24 antigen quantification method. Through using different dosages of anthracene ring type medicines, results show that the anthracene ring type compounds have obvious anti-HIV effects so that the compounds can be applied for preparing medicines treating AIDS.

Description

technical field [0001] The invention belongs to the technical field of medicines, and specifically relates to the application of anthracycline compounds in pharmacy, more specifically to the application of anthracycline compounds in the preparation of medicines for treating AIDS. [0002] technical background [0003] AIDS is a serious infectious disease caused by Human Immunodeficiency Virus (HIV) infection. As a chronic infectious disease that can directly destroy the human immune system, AIDS has become one of the diseases that seriously threaten human health in the world. According to data from the United Nations Program on AIDS (UNAIDS), as of the end of 2011, a total of 34.2 million people worldwide were infected with HIV. At present, the AIDS epidemic in my country is in a period of rapid growth, with more than 780,000 infected people (UNAIDS, 2011). Therefore, the prevention and treatment of HIV / AIDS has become a social problem and a major scientific research topic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P31/18
CPCA61K31/704
Inventor 代绍兴黄京飞陈欢郑永唐李功华李文兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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