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Rapid diagnosis kit for tuberculosis and preparation method thereof

A rapid diagnosis and kit technology, applied in the field of medical testing, to achieve the effects of improving stimulation efficiency, improving detection specificity, improving detection efficiency and clinical labor intensity

Inactive Publication Date: 2017-08-15
广州市宝创生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently used tuberculosis screening methods all have different deficiencies

Method used

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  • Rapid diagnosis kit for tuberculosis and preparation method thereof
  • Rapid diagnosis kit for tuberculosis and preparation method thereof
  • Rapid diagnosis kit for tuberculosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0041] 1. Detection purpose

[0042] In this example, the tuberculosis rapid diagnosis kit and detection method described in Example 1 were used to evaluate the detection effect of the kit, as well as the corresponding specificity and sensitivity.

[0043] 2. Test samples

[0044] The test samples in Table 1 are the clinical samples undertaken by Guangdong Second People's Hospital (Guangdong Provincial Emergency Hospital), which were confirmed as tuberculosis positive and 78 negative samples by laboratory confirmation methods.

[0045] The test samples in Table 2 are 60 cases of tuberculosis positive samples from the BCG inoculated patients and 22 cases of atypical mycobacterium infection in the clinical samples undertaken by the Second People's Hospital of Guangdong Province (Guangdong Provincial Emergency Hospital).

[0046] The detection samples in Table 3 are 219 cases of clinically collected whole blood samples (the Second People's Hospital of Guangdong Province (Guangdo...

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Abstract

The invention discloses a rapid diagnosis kit for tuberculosis, and the kit comprises a specific tuberculosis stimulating antigen and a test paper strip, wherein the test paper strip is formed by overlapping a sample pad, a fluorescent pad, a coating film and absorbent paper serially on a bottom plate, the fluorescent pad is combined with fluorescent microspheres, the fluorescent microspheres are coupled with r-interferon binding antibodies, and the coating film is coated with r-interferon monoclonal captured antibodies; and the specific tuberculosis stimulating antigen comprises 11 peptide fragments with the amino acid sequences as shown respectively in SEQ ID NO. 1 to SEQ ID NO. 11.

Description

technical field [0001] The invention belongs to the field of medical detection, and in particular relates to a tuberculosis rapid diagnosis kit and a preparation method thereof. Background technique [0002] At present, tuberculosis detection technology is divided into four categories: 1. Sputum smear, which is simple in technology and cheap in charge, is the main means of screening, but its positive rate is low, and it cannot distinguish between Mycobacterium tuberculosis and atypical Mycobacterium tuberculosis, making it The clinical significance is limited; 2. The immunological detection method based on specific antigen and antibody is simple to operate, but the specificity and sensitivity are not good, so it is limited in clinical promotion; 3. Based on the tuberculosis branch The nucleic acid amplification detection method of Bacillus DNA, whether it is ordinary PCR amplification or isothermal amplification method, its detection principle is to detect the presence of My...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/558G01N33/531
CPCG01N33/6893G01N33/531G01N33/558
Inventor 杨祥胜
Owner 广州市宝创生物技术有限公司
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