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40 results about "Atypical mycobacterium" patented technology
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Nontuberculous mycobacteria (NTM), also known as environmental mycobacteria, atypical mycobacteria and mycobacteria other than tuberculosis (MOTT), are mycobacteria which do not cause tuberculosis or leprosy (also known as Hansen's disease).
Rapid identification method and kit for MTBC (mycobacterium tuberculosis complex)
InactiveCN104561245AShorten diagnostic timeSimple and fast operationMicrobiological testing/measurementFluorescence/phosphorescenceFluorescenceRapid identification
The invention belongs to the field of a detection reagent, and relates to a detection and identification kit for MTBC (mycobacterium tuberculosis complex) and an identification method of the MTBC. According to the method, fluorescence probes and amplification primers for detecting the MTBC are designed through sequence alignment, mycobacterium and the MTBC specific SNP (single nucleotide polymorphism) loci on an rrs gene are detected based on a real-time fluorescent quantitative PCR (polymerase chain reaction) platform and with an asymmetric PCR amplification technology and a probe melting curve analysis technology, so that mycobacteria are identified, and the MTBC and NTM (nontuberculosis mycobacteria) are further identified. The method has the characteristics of convenience in operation, short detection time and high specificity and sensitivity.
Owner:FUDAN UNIV
Methods for treating pulmonary non-tuberculous mycobacterial infections
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and / or NTM culture conversion to negative during or after the administration period.
Owner:INSMED INC
Multiplex polymerase chain reaction (PCR) kit for identifying mycobacterium tuberculosis
InactiveCN102533959ASimple and fast operationEasy to operateMicrobiological testing/measurementSequence designAcid-fast
Owner:HUAZHONG AGRI UNIV
Specific epitope based immunological diagnosis of tuberculosis
ActiveUS7838013B2Easy to identifyTesting is superfluousBacterial antigen ingredientsMicrobiological testing/measurementBCG vaccineDiagnostic tools
The currently used method for immunological diagnosis of tuberculosis infection, the tuberculin skin test, is problematic for a number of reasons; it has low specificity in BCG vaccinated individuals, a high interobserver variance and requires skill to be read and interpreted. Furthermore it requires an extra visit to the clinic to have the test read. Both people vaccinated with BCG and those exposed to non-tuberculosis mycobacteria give a positive skin test result similar to that seen in a TB infected individual. This also applies for purified protein derivative (PPD) when used in a blood cell based test. The present invention discloses the development of an immunological TB diagnostic tool based on a combination of epitopes from proteins encoded by regions of the M. tuberculosis (M. tub.) genome, that are not present in the BCG vaccine strain or in the most common non-tuberculosis mycobacteria.
Owner:STATENS SERUM INST
Test paper and method for checking mycobacteria tuberculosis and non-mycobacteria tuberculosis nucleic acid amplifying products
The invention provides a test paper of nucleic acid amplification product for detecting tubercle mycobacterium (TB) and Nontuberculous mycobacteria (NTM), comprising (a) (avidin-gold release region) and (b) test belt. The invention further provides a method of detecting TB and NTM, comprising (a) amplifying the sample DNA of primer having mark; (b) mixing the amplified DNA product by electrophoretic buffer; (c) dipping the test paper in the mixture; and (d) flowing the mixture in the reaction area of the paper.
Owner:ASIAGEN CORP
Method and kit for detecting mycobacterium tuberculosis and nontuberculous mycobacterium
InactiveCN101560568AMicrobiological testing/measurementMicroorganism based processesMicrobiologyNontuberculous mycobacterium
Owner:ASIAGEN CORP
Method for detecting mycobacterium tuberculosis and nontuberculous mycobacteria by using dual real-time polymerase chain reaction
InactiveUS20130210005A1Improve efficiencySugar derivativesMicrobiological testing/measurementNucleotideNucleotide sequencing
Disclosed are a primer set and / or a probe capable of detecting specific nucleotide sequences of MTC and NTM, a kit for the detection of MTC and NTM, comprising the same, and a method for detecting MTC and NTM by duplex real-time PCR using the same. Useful in detecting genes characteristic of MTC and NTM, the primer sets and / or probes, detection kits, and detection methods can be applied as the clinical diagnosis of diseases caused by MTC and NTM, and therefore find applications in the medical fields including hospitals, research institutes, etc.
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Kit for identifying Mycobacterium tuberculosis and nontuberculous mycobacteria and application method thereof
InactiveCN102229999AIssues that take up to 4-6 weeks to resolveShort detection timeMicrobiological testing/measurementFluorescence/phosphorescenceBacteroidesMycobacterium tuberculosis culture
The invention discloses a fluorescence quantitative nucleic acid detection technique for differentiating and identifying Mycobacterium tuberculosis and nontuberculous mycobacteria in one step based on the features of dual-channel fluorescence quantitative detection, which has a short detection time, provides reliable detection results and achieves the quantitative detection. The invention adopts the technical scheme as follows: a kit for identifying Mycobacterium tuberculosis and nontuberculous mycobacteria is provided, which comprises primers for PCR (polymerase chain reaction) amplification of strains to be detected and probes for fluorescence quantitative detection. According to the invention, according to the difference in gene sequence of different types of mycobacteria, the fluorescence probes are designed to differentiate Mycobacterium tuberculosis from nontuberculous mycobacteria; and the differentiation and identification is performed at the levels of gene sequence and molecular structure of bacterial strains, so as to ensue more accurate and more reliable classification. The invention solves the problem that in the conventional identification method, the differentiation based on the growth forms of bacterial strains needs a long period of time up to 4 to 6 weeks.
Owner:亚能生物技术(深圳)有限公司
Primers, probes, method and kit for detecting mycobacterium tuberculosis specific gene
InactiveCN107841568AImprove accuracyNo cross reactionMicrobiological testing/measurementMicroorganism based processesFluorescencePcr method
The invention relates to the technical field of molecular biology and discloses primers, probes, method and kit for detecting a mycobacterium tuberculosis specific gene. Through a Taqman probe real-time fluorescence PCR method, primers and fluorescent labeled probes are designed according to (gyrB) and 16S rDNA nucleic acid conserved regions. An enzyme and a sample nucleic acid are added into a PCR detection mixed solution of the primers and probes, a FAM channel of a fluorescence PCR device is used for amplification and a desired gene is detected through change of a fluorescence signal. The primers, probes, method and kit have the characteristics of high accuracy, strong specificity and high sensitivity and can realize fast and accurate detection of mycobacterium tuberculosis (MTB) and non-tuberculous mycobacteria (NTM).
Owner:宁波基内生物技术有限公司
Method for detecting mycobacterium tubericulosis and nontuberculous mycobacteria by using dual real-time polymerase chain reaction
InactiveCN103038348AEfficient detectionMicrobiological testing/measurementMicroorganism based processesMicrobiologyClinical diagnosis
The present invention provides: a primer set and / or a probe for detecting Mycobacterium tubericulosis and nontuberculous mycobacteria specific for a Mycobacterium tubericulosis-specific IS6110 gene or 16S rRNA gene and a nontuberculous mycobacteria-specific 16S rRNA gene; a kit for detecting Mycobacterium tubericulosis and nontuberculous mycobacteria, containing the same; and a method for detecting Mycobacterium tubericulosis and nontuberculous mycobacteria through dual real-time polymerase chain reaction by using the same. The present invention can provide a clinical diagnosis means capable of more effectively detecting and analyzing Mycobacterium tubericulosis and / or nontuberculous mycobacteria at the same time.
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Mycobacterium culture medium, preparation method and method for culture, identification and drug sensitivity test
InactiveCN101560490AEasy to operateEasy to useBacteriaMaterial analysis by observing effect on chemical indicatorGlycerolAntibiotic Y
The invention relates to a mycobacterium culture medium, a preparation method and a method for culture, identification and drug sensitivity test. The culture medium contains buffer solution, glycerol, trace element, albumin, glucose, antibiotic and a colour-changing agent and the like. The first fourteenth components are added in distilled water, pH is adjusted, high-pressure sterilization is carried out, methyl thiazolyldiphenyl tetrazolium, albumin-oleic acid-glucose liquid and four types of antibiotics are added and the culture medium is obtained. Specimen after pre-treatment is taken and added into the culture medium for culture, and after the color of ae culture hole is changed, the mycobacterium tuberculosis or nontuberculous mycobacteria and drug sensitivity are judged according to the condition of color change of identification holes and drug-sensitivity testing holes. The invention can obtain the results of mycobacterium culture, identification and drug-sensitivity measurement by only one-time inoculated culture, has simple operation, practicability, easy standardization, high positive rate, fastness, strong practicability, low cost, easy promotion and wide application, and is applicable to mycobacterium culture, identification and drug-sensitivity test in the environments of human bodies, animals and sewage and the like.
Owner:熊礼宽
Method for detecting mycobacterium tuberculosis and nontuberculous mycobacteria using duplex polymerase chain reaction
InactiveCN103038346AEfficient clinical diagnostic toolsMicrobiological testing/measurementMicroorganism based processesMicrobiologyClinical diagnosis
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Gold-labeled diagnosis reagent based on combined protein for tubercle bacillus
InactiveCN1844929AIncreased sensitivityImprove featuresSugar derivativesBiological testingAntigenSpecific test
The invention discloses a medical immunity diagnose technique, especially providing a bacillus tubercle mycobacterium gold mark diagnose agent based on combined protein. Wherein, it uses B cell antigen determinants of bacillus tubercle mycobacterium main excrete proteins as ESAT6, MPT64, PstS-1, Ag85B to combine a new group of protein as antigen, as the specific test antibody in the clinic serology diagnosis of phthisis. The invention combines the B cell antigen determinants of bacillus tubercle mycobacterium main excrete proteins to be displayed by gene project, and purified to attain one new protein, and via gold mark filter method to test the serum of tuberculosis patient. The invention has high sensitivity, simple operation, and high speed, which can identify the sensitized condition caused by contacting the non- bacillus tubercle mycobacterium or inoculating beg vaccine, and the real bacillus tubercle mycobacterium. It can be used in the clinic serology diagnosis of clinic tuberculosis.
Owner:THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
Method for detecting mycobacterium tuberculosis and nontuberculous mycobacteria using duplex real-time polymerase chain reaction and melting curve analysis
InactiveCN103038347AMicrobiological testing/measurementMicroorganism based processesMicrobiologyMelting curve analysis
The present invention provides: primers for detecting mycobacterium tuberculosis and nontuberculous mycobacteria, the primers being specific respectively to a mycobacterium tuberculosis-specific IS6110 gene and a nontuberculous mycobacteria-specific 16S rRNA; a mycobacterium tuberculosis and nontuberculous mycobacteria detection kit including the primers; and a method for detecting mycobacterium tuberculosis and nontuberculous mycobacteria by means of a duplex real-time polymerase chain reaction using the primers and by means of a melting curve analysis. The present invention can provide a clinical diagnostic means that can quickly detect mycobacterium tuberculosis and / or nontuberculous mycobacteria simultaneously and more effectively, at a lower cost, since the invention does not use a sequence-specific probe.
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Kit for detecting nontuberculous mycobacteria, detection method and application thereof
ActiveCN114410810AShorten detection timeEasy to operateMicrobiological testing/measurementDNA/RNA fragmentationMedicineMicrobiology
The invention discloses a kit for detecting nontuberculous mycobacteria, a detection method and application thereof, the rapid and accurate detection and identification of 14 nontuberculous mycobacteria are realized through a designed specific primer combination probe group, melting curve analysis is carried out on an amplification product obtained by carrying out multiple fluorescent PCR amplification on a primer group, and the detection result is accurate. The melting temperature is obtained, and the 14 non-tuberculosis mycobacteria can be rapidly and accurately detected according to the melting temperature. The PCR-HRM detection method provided by the invention has the advantages of high detection flux, obvious shortening of the detection time of the nontuberculous mycobacteria, high authenticity, high accuracy, strong specificity, high sensitivity and strong anti-interference ability, and the sensitivity of the PCR-HRM detection method provided by the invention is 10-20 times higher than that of clinical general requirements.
Owner:广州蔚捷生物医药科技有限公司
Application of rifamycin-quinazine ketone coupling molecule
The invention discloses application of a rifamycin-quinazine ketone coupling molecule or a three-dimensional isomer thereof or hydrate thereof or a deuterated material thereof, ester thereof, a solvent compound thereof, a crystal form thereof, a metabolic product thereof or pharmaceutically acceptable salt thereof or a pro-drug thereof in resisting nontuberculous mycobacteria. The rifamycin-quinazine ketone coupling molecule has a structure as shown in formula I. The rifamycin-quinazine ketone coupling molecule disclosed by the inention or the three-dimensional isomer thereof or hydrate thereof or the deuterated material thereof, ester thereof, the solvent compound thereof, the crystal form thereof, the metabolic product thereof or the pharmaceutically acceptable salt thereof or the pro-drug thereof can effectively resist nontuberculous mycobacteria, and can be used for treating infection caused by human nontuberculous mycobacteria.
Owner:TENNOR THERAPEUTICS (SUZHOU) LTD
Method for detecting mycobacterium tuberculosis and nontuberculous mycobacteria using duplex polymerase chain reaction
InactiveUS20130177914A1Improve efficiencyMicrobiological testing/measurementDNA/RNA fragmentationDuplex pcrMicrobiology
Disclosed are primer sets specific for the IS6110 or 16S rRNA gene characteristic of MTC and for the 16S rRNA gene characteristic of NTM, kits for the detection of MTC and NTM, comprising the same, and methods for detecting MTC and NTM by duplex PCR using the same. Because the primers are exclusive to Mycobacterium tuberculosis and nontuberculous mycobacteria, the methods, which can employ an inexpensive typical PCR cycler, can be a clinical diagnostic means useful for the detection of both Mycobacterium tuberculosis and nontuberculous mycobacteria at the same time, with higher efficiency.
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Selective detection method for Mycobacterium tuberculosis and nontuberculous mycobacteria and kit using same
ActiveUS10301686B2Improve efficiencyConvenient and efficient detectionMicrobiological testing/measurementMicroorganism based processesMicrobiologyActin
The present invention relates to a method for specifically detecting Mycobacterium tuberculosis and nontuberculous mycobacteria by simultaneously amplifying and analyzing target genes using various primers and probes, and a kit using same. The method of the present invention is capable of selectively detecting Mycobacterium tuberculosis and nontuberculous mycobacteria with very high efficiency through a multiplex real-time polymerase chain reaction (PCR) using probes and primers specific to target genes (particularly, IS6110, 16S rRNA and β-actin). Also, the kit of the present invention is capable of conveniently and efficiently detecting the target genes in a sample through a multiplex real-time PCR. Therefore, the method and the kit of the present invention are capable of selectively detecting with ease whether or not there is an infection with Mycobacterium tuberculosis or nontuberculous mycobacteria in a sample, and can be more accurately applied to the treatment of diseases on the basis thereof.
Owner:HYUNIL BIO
Combination in treatment of nontuberculous mycobacterial diseases
PendingCN113271930AAntibacterial agentsHeterocyclic compound active ingredientsTuberculosis mycobacteriumQuinoline
The present invention relates to a combination of bedaquiline, a macrolide (e.g. clarithromycin) and, optionally, ethambutol for use in the treatment of a disease associated with nontuberculous mycobacteria (NTM).
Owner:JANSSEN PHARMA NV
Thiazolyl peptides for the treatment nontuberculous mycobacterial infections
The present invention provides novel thiazolyl peptide compounds and their pharmaceutically acceptable salts either alone or in combinations with Rifampicin, Amikacin and Clarithromycin against infections caused by Nontuberculous mycobacteria, especially Mycobacterium avium (M. avium) and Mycobacterium gordonae (M. gordonae).
Owner:NAT CENT FOR POLAR & OCEAN RES +1
Application of besifloxacin in preparation of medicine for treating tuberculosis
PendingCN113855681AEnhanced inhibitory effectRaise the possibilityAntibacterial agentsHeterocyclic compound active ingredientsTreating tuberculosisPharmacology
The invention discloses application of besifloxacin or a pharmaceutical composition containing besifloxacin in preparation of a medicine for preventing and / or treating tuberculosis, and relates to the technical field of medicines. Experiments prove that the besifloxacin has a good inhibition effect on mycobacteria and nontuberculous mycobacteria in vitro, can be used for preparing the medicine for resisting the mycobacteria tuberculosis and the medicine for preventing and / or treating tuberculosis, and provides a new medicine choice for treating tuberculosis.
Owner:BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
Method for the detection of Mycobacterium tuberculosis and nontuberculous mycobacteria by the use of dual real-time polymerase chain reaction
InactiveCN103038348BEfficient detectionMicrobiological testing/measurementMicroorganism based processesNucleotideNucleotide sequencing
Disclosed are a primer set and / or a probe capable of detecting specific nucleotide sequences of MTC and NTM, a kit for the detection of MTC and NTM, comprising the same, and a method for detecting MTC and NTM by duplex real-time PCR using the same. Useful in detecting genes characteristic of MTC and NTM, the primer sets and / or probes, detection kits, and detection methods can be applied as the clinical diagnosis of diseases caused by MTC and NTM, and therefore find applications in the medical fields including hospitals, research institutes, etc.
Owner:UNIV OF ULSAN FOUND FOR IND COOPERATION
Combination in the treatment of nontuberculous mycobacterial diseases
PendingUS20220062319A1Antibacterial agentsHeterocyclic compound active ingredientsTuberculosis mycobacteriumQuinoline
The present invention relates to a combination of bedaquiline, a macrolide (e.g. clarithromycin) and, optionally, ethambutol for use in the treatment of a disease associated with nontuberculous mycobacteria (NTM).
Owner:JANSSEN PHARMA NV
Pyridyl hydrazones for the treatment of tuberculosis and related diseases
Owner:TECNIMEDE SOC TECNICO MEDICINAL
Quinolyl hydrazones for the treatment of tuberculosis and related diseases
The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and / or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and / or caused by Micobacterium leprae.
Owner:TECNIMEDE SOC TECNICO MEDICINAL
Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria
ActiveUS9532986B2Effectively eradicateImprove efficacyAntibacterial agentsPowder deliveryIntensive care medicineLiposome
Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Owner:GRIFOLS +1
Microfluidic detection system for identifying nontuberculous mycobacterium strains
PendingCN114456914AEnable high-throughput detectionAchieving Specific DetectionBioreactor/fermenter combinationsBiological substance pretreatmentsTuberculosis mycobacteriumSpecific detection
The invention relates to a microfluidic detection system for non-tuberculosis mycobacterium strain identification, the detection system uses a microfluidic chip for detection, the microfluidic chip comprises a chip body, the chip body is provided with a sample adding hole, a main flow channel, a micro flow channel and a reaction hole; the reaction holes comprise a positive quality control hole, a positive control hole and at least one detection hole; the sample adding hole is communicated with the main runner; each reaction hole is communicated with the main flow channel through the micro flow channel; and each detection hole contains a specific detection primer group of the nontuberculous mycobacterium. Through the microfluidic monitoring system, more than ten nontuberculous mycobacteria strains can be simultaneously subjected to specific detection under isothermal conditions, and the microfluidic monitoring system has the advantages of good specificity, high sensitivity, simplicity in operation, rapidness in detection and the like, and has a good clinical application prospect.
Owner:GUANGZHOU DEAOU MEDICAL TECH CO LTD
Gold-labeled diagnosis reagent based on combined protein for tubercle bacillus
InactiveCN100401066CIncreased sensitivityImprove featuresSugar derivativesBiological testingAntigenSpecific test
Owner:THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
Method for identifying Mycobacterium tuberculosis and non-tuberculous mycobacteria, and special reagent kit therefor
ActiveCN101413031BRapid identificationInstrument requirements are simpleMicrobiological testing/measurementFluorescenceRibonucleotide synthesis
The invention discloses a method for identifying Mycobacterium tuberculosis and nontuberculosis mycobacteria and a special reagent kit thereof. The reagent kit for identifying the Mycobacterium tuberculosis and the nontuberculosis mycobacteria comprises a primer and a probe, wherein the primer comprises four primers, and ribonucleotide sequences of the four primers are sequence 1, sequence 2, sequence 4, and sequence 5 in a sequence table respectively; the probe comprises two probes, and ribonucleotide sequences of the two probes are sequence 3 and sequence 6 in the sequence table respectively; 5' ends of the probes are provided with fluorescent substances, and 3' ends of the probes are provided with quenching substances; and the fluorescent substances at the 5' ends of the two probes are different. The reagent kit has the advantages that the reagent kit can quickly identify the Mycobacterium tuberculosis and the nontuberculosis mycobacteria, has simple requirement on instruments, low cost and simple operation, and has broad application prospect on early diagnosis and differential diagnosis of tuberculosis.
Owner:BOAO BIOLOGICAL CO LTD +1
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