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Container for nicotine solution

A technology of nicotine and solution, which is applied in the field of electronic vapor supply system, and can solve problems such as loss of nicotine content

Active Publication Date: 2019-02-26
NICOVENTURES TRADING LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During this storage period, loss of nicotine content may occur

Method used

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  • Container for nicotine solution
  • Container for nicotine solution
  • Container for nicotine solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-p

[0061] The mensuration of embodiment 1-pKa value

[0062] The determination of the nicotine pKa value in the glycerol / water system uses the document "Spectroscopic investigations into the acid-base properties of nicotine at different temperatures", Peter M. Clayton , Carl A. Vas , Tam T.T. Bui , Alex F. Drake and Kevin McAdam , Anal.Methods, 2013, 5, 81-88 described the basic method implementation, and summarized below. Since the system is mainly non-aqueous, the parameter p s Ka 2 , where the subscript s refers to the solvent composition in this predominantly non-aqueous system, and the subscript 2 refers to the pKa value of the pyrrolidinyl nitrogen.

[0063] Further information on the determination of the pKa values ​​of nicotine in e-cigarette solutions is provided in the document "Use of chiroptical spectroscopy to determine the ionisation status of (S)-nicotinein e-cigarette formulations and snus", Clayton et al, ST 49, CORESTA Congress, Québec City, Canad...

Embodiment 2-p

[0070] Example 2 - Determination of pH and % Protonation

[0071] The feed was formulated as described and the pH was determined as described in Example 1. Based on the pKa determined in Example 1 of 7.26, the percentage of protonated nicotine was calculated using the Henderson-Hasselbalch equation. The results obtained are listed in the table below.

[0072]

[0073]

[0074]

Embodiment 3

[0075] Example 3 - Storage stability of nicotine in solution exposed to PP and PC

[0076] The absorption of nicotine has been studied with many materials suitable for use in e-cigarettes. The purpose of this study was to determine whether there was any absorption of nicotine from the liquid formulation into the various materials over time. 5 nicotine solutions containing 3.7 wt% nicotine, 9% water, and 87.3% glycerin were filled into 40 amber glass vials. Polypropylene and polycarbonate chips were added to the solutions (except for control samples), and the vials were sealed with screw caps and stored in an oven at room temperature or 40°C for 8 weeks. Sampling was done on day 1, then at 1, 2, 4 and 8 weeks.

[0077] Accurately weighed aliquots (a qt) of the solution were removed from the vials using a Pasteur pipette (Pa t pp tt) and diluted with water (40 samples, 1). The weight of the final solution was also recorded. Using the at Aq t system incorporating a diode arra...

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PUM

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Abstract

A contained nicotine solution is provided, comprising (i) a container; and (ii) a nicotine solution contained within the container, wherein at least 5% by weight of the nicotine present in the solution is in a protonated form, wherein the At least a portion of said container that the nicotine solution contacts is formed from polycarbonate or polypropylene.

Description

technical field [0001] The present disclosure relates to containers for nicotine solutions, and to electronic vapor delivery systems, such as electronic nicotine delivery systems (eg, electronic cigarettes), incorporating such containers. Background technique [0002] Electronic vapor delivery systems, such as electronic cigarettes, typically contain a reservoir of liquid to be vaporized, usually containing nicotine. When a user inhales on the device, the heater is activated to vaporize a small amount of liquid, which is thus inhaled by the user. [0003] The use of e-cigarettes has grown rapidly in the UK and it is estimated that more than one million people in the UK now use them. [0004] The liquid to be vaporized in electronic cigarettes is usually a solution containing nicotine. The solvent can be, for example, glycerol. The vaporizing portion of the equipment is usually designed for multiple purposes, although single-purpose equipment does exist. In both multi-use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A24B15/16A24F47/00A24F40/10A24F40/42
CPCA24B15/16A24B15/167A24F40/10A24F40/42A24B15/10A24B15/30A61K31/465A61M15/06B29K2069/00B29K2023/12B29L2031/7416B29L2031/7142
Inventor 凯文·杰勒德·麦克亚当康纳·布鲁顿玛丽娜·特拉尼
Owner NICOVENTURES TRADING LTD