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Mulberry leaf, chrysanthemum and Chinese yam compound polysaccharide with heat clearing, yin nourishing and blood sugar lowering functions and preparation method thereof

A compound polysaccharide and mulberry leaf polysaccharide technology, which is applied to medical preparations containing active ingredients, antipyretics, drug combinations, etc., can solve the problem of insignificant hypoglycemic effect, achieve the best function of clearing away heat and nourishing yin, and improve appearance Condition and mental outlook, effect of lowering triglyceride and total cholesterol

Inactive Publication Date: 2017-09-08
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are already some supplementary hypoglycemic health products on the market that use the combination of mulberry leaves, chrysanthemums, and yams, such as the Sangtang Drink oral liquid developed by Infinitus (China) Co., Ltd., but the hypoglycemic effect is not significant

Method used

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  • Mulberry leaf, chrysanthemum and Chinese yam compound polysaccharide with heat clearing, yin nourishing and blood sugar lowering functions and preparation method thereof
  • Mulberry leaf, chrysanthemum and Chinese yam compound polysaccharide with heat clearing, yin nourishing and blood sugar lowering functions and preparation method thereof
  • Mulberry leaf, chrysanthemum and Chinese yam compound polysaccharide with heat clearing, yin nourishing and blood sugar lowering functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of mulberry leaf polysaccharide

[0035] Take an appropriate amount of mulberry leaves, add 20 times of water, decoct for 2 hours, filter, collect the filtrate, add 20 times of water to the filter residue, decoct for 1 hour, filter, and combine the 2 filtrates; the concentrated solution is centrifuged, the precipitate is discarded, and the supernatant is passed through 80nm pore size The ultrafiltration membrane is separated, and the polysaccharide with a molecular weight of less than 100,000 Daltons is obtained, then concentrated, alcohol precipitation, centrifugation and drying, and pulverized to obtain the mulberry leaf polysaccharide.

Embodiment 2

[0036] Example 2: Preparation of mulberry leaf polysaccharide

[0037] The remaining supernatant after membrane filtration in Example 1 was separated again by an ultrafiltration membrane with a pore size of 500 nm to obtain a polysaccharide with a molecular weight of 100,000 to 600,000 Daltons, followed by concentration, alcohol precipitation, centrifugation and drying, and pulverization to obtain mulberry. Leaf polysaccharides.

Embodiment 3

[0038] Example 3: Preparation of mulberry leaf polysaccharide

[0039] In Example 2, the remaining supernatant after membrane filtration is a polysaccharide with a molecular weight of more than 600,000 Daltons, which is concentrated, alcohol-precipitated, centrifuged and dried to obtain mulberry leaf polysaccharide.

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Abstract

Belonging to the field of drugs and health care products, the invention particularly discloses a mulberry leaf, chrysanthemum and Chinese yam compound polysaccharide and application thereof. The compound polysaccharide provided by the invention is composed of mulberry leaf polysaccharide, chrysanthemum polysaccharide and Chinese yam polysaccharide, wherein the molecular weight of the mulberry leaf polysaccharide is 100-600 thousand Dalton, the molecular weight of the chrysanthemum polysaccharide is 40-80 thousand Dalton, and the molecular weight of the Chinese yam polysaccharide is 40-80 thousand Dalton. The compound polysaccharide is formed by combination of mulberry leaf polysaccharide, chrysanthemum polysaccharide and Chinese yam polysaccharide of specific molecular weight segment, can significantly reduce the food intake, water intake and urine volume of internal heat and yin deficiency high blood sugar rat models, and increase the rat weight, also can reduce fasting blood glucose, improve sugar tolerance, reduce the insulin content, improve insulin resistance, lower triglyceride and total cholesterol, improve hyperlipidemia symptoms, lower cAMP, cGMP, CD4+ / CD8+ and other immune indexes, improve immune function anomalies, and improve the appearance states and mental outlook of internal heat and yin deficiency rats.

Description

technical field [0001] The invention belongs to the field of medicines and health-care products, in particular to a mulberry leaf chrysanthemum yam compound polysaccharide and an application thereof, in particular to a mulberry leaf chrysanthemum yam compound polysaccharide with functions of clearing heat, nourishing yin and lowering blood sugar. Background technique [0002] Hyperglycemia occurs when blood sugar levels are above the normal range. Under normal circumstances, the human body can maintain the balance between the source and the destination of blood sugar through the two major regulatory systems of hormone regulation and neuromodulation, so that blood sugar can be maintained at a certain level. However, under the combined action of genetic factors (such as family history of diabetes) and environmental factors (such as unreasonable diet, obesity, etc.), the two major regulatory functions are disturbed, and blood sugar levels will rise. Short-term, one-time high b...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P3/10A61P29/00A23L33/125
CPCA23L33/125A61K31/715A23V2002/00A61K2300/00A23V2200/324A23V2200/328
Inventor 胡明华尹西拳马忠华马方励罗珍徐路
Owner INFINITUS (CHINA) CO LTD
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