Palette-based systems for analyte characterization

An analyte, characterization technique applied in the field of pallet-based systems for analyte characterization that addresses inflexible design, rigidity, and increased system complexity

Active Publication Date: 2017-09-12
TRACE ABILITY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Those systems that use disposable cartridges still contain liquid handling tubing and valves, and must still inherit the rigid and inflexible design of the host system
In this implementation, the overall system complexity is increased due to the mechanical interface between the valve and its actuator and the electrical and fluid connections between the disposable and permanent components of the system

Method used

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  • Palette-based systems for analyte characterization
  • Palette-based systems for analyte characterization
  • Palette-based systems for analyte characterization

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0223] The following description illustrates the manufacture 13 An example of the synthesis method of N-ammonia. 13 The N-ammonia is generated on target, so the synthesis system is fairly simple and mainly consists of filtration and dilution steps done within the system. refer to Figure 5 , irradiated water delivered from the accelerator is introduced into kit A through inlet port 530 and passes through anion exchange column 532 located within kit A; the irradiated water is mixed with water and sodium chloride provided by kit A; The mixture passes through a filter (biofilm) 501 located in kit A.

[0224] Quantitative production and clinical models

[0225] Kit A ( Figure 4 ) placed inside the liquid handler. A liquid handler may be any suitable device that can perform the function of injecting, aspirating or moving a liquid sample from one container or location to another. For example, a liquid handler may include an automated pipette with replaceable pipette tips (fun...

Embodiment approach

[0334] A method of sterility testing based on the labeling of living cells with a reagent that allows quantification of the number of cells by optical detection in the tray. A device that can detect a light signal from labeled living cells and convert it to the number of living cells in a sample; a device for sterility assessment, which includes a channel, wherein the channel has one or more electrodes; the channel connected to a reservoir; channels connected to two or more reservoirs; cross-section of the channel comparable to the size of a living cell; electrodes make measurements; signals differ in the presence and absence of living cells close to the electrodes; This signal can be used to count live cells; can contain more than one channel; all channels run in parallel; all channels have the same starting container; all channels have the same final container; the tray contains any combination of the following reagents: pH indication agent, Kryptofix TM Indicators, scintil...

other Embodiment approach

[0339] Other embodiments include canisters used as temporary containers to transfer materials between containers on pallets or from pallets external to the system; designed to transfer materials (end products, analyte samples, or other Canisters delivered to the end user and used directly without further transfer of enclosed material; canisters designed to interface with hardware other than pallets; canisters containing radioactive shielding; in one or more containers Plates and tanks containing silica, modified silica, ion exchange resins or any other adsorbent.

[0340] The radiochemistry system was designed to allow periodic sampling and analysis of the reaction mixture within the same system (obtained at various time points throughout the synthesis and not limited to sampling the final product). Such systems are designed to automatically receive pallets from a storage location and automatically discharge used pallets and cans into receptacles (possibly shielded in some emb...

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PUM

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Abstract

Systems, devices, and methods are provided that facilitate synthesis and analysis of chemical compounds on a convenient and automatable palette-based platform. Palettes utilized for analysis support a variety of functional sites, including test wells, separation devices, and test sites that have rapid thermal equilibration, on a single test fixture. This permits both the performance of a wide variety of tests and of tests with different temperature requirements or responses in parallel, on the same test fixture. Such systems, devices, and methods are particularly suitable for production and characterization of radiopharmaceuticals.

Description

[0001] This application claims the benefit of US Provisional Application No. 62 / 056,529, filed September 27, 2014, and US Provisional Application No. 62 / 171,183, filed June 4, 2015. These and all other referenced external materials are hereby incorporated by reference in their entirety. Whenever a reference incorporated by reference has a definition or usage of a term that is inconsistent or contrary to the definition of the term provided herein, the definition of the term provided herein is deemed to control. technical field [0002] The following description relates to systems and devices for chemical synthesis and / or analysis and methods of using the same, in particular for radiopharmaceuticals in medical imaging, such as positron emission tomography (PET) or single photon emission computed tomography imaging (SPECT); and / or therapy with such radioactive compounds. Background technique [0003] The following description includes information helpful for understanding the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/62G01N30/90
CPCG01N30/62G01N30/90G01N2030/77G01N21/253G01N2035/103G01N2035/1034A61K51/0491G01N30/74B01L3/502715B01L3/502753B01L7/00B01L2200/0605B01L2200/0631B01L2200/0684B01L2200/141B01L2200/16B01L2300/021B01L2300/022B01L2300/044B01L2300/0645B01L2300/0672B01L2300/0681B01L2300/0829B01L2300/0838B01L2300/0883B01L2300/161B01L2400/0487G01N21/80
Inventor A·Y·列别杰夫A·M·埃利扎罗夫
Owner TRACE ABILITY INC
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