Novel silver-containing antibacterial product, and preparation method thereof

Abstract

The invention relates to a novel silver-containing antibacterial product, and a preparation method thereof. The novel silver-containing antibacterial product contains a silver-containing alcohol amine chelate as an antibacterial component; the silver-containing alcohol amine chelate is uniformly distributed in, and is combined with the internal part and / or the surface of the novel silver-containing antibacterial product. The novel silver-containing antibacterial product contains, by weight, 0.01 to 10% of silver, and the moisture absorption capability of the novel silver-containing antibacterial product is higher than 6g / g. The invention also provides a preparation method of the novel silver-containing antibacterial product, and a silver-containing dressing prepared from the novel silver-containing antibacterial product. The antibacterial spectrum of the novel silver-containing antibacterial product is wide; the novel silver-containing antibacterial product possesses high antibacterial activity on Gram-negative bacteria and Gram-positive bacteria, and light stability; effect is achieved quickly; and the novel silver-containing antibacterial product can be widely used for chronic infective wounds.

Description

technical field [0001] The invention relates to a silver-containing antibacterial product and a preparation method thereof, in particular to a silver-containing product containing a silver-containing alcoholamine chelate. The article can be used in medical dressings and other antimicrobial fields. Background technique [0002] With the improvement of people's living standards and changes in eating habits, the human disease spectrum presents some new features. Chronic exudative wounds such as venous ulcers, arterial ulcers, diabetic ulcers, traumatic ulcers, and pressure ulcers caused by diabetes, pressure sores, decubitus ulcers, and hypertension have seriously affected people's health. Exudative wounds are a type of chronic wounds that secrete a large amount of exudate, and the main components of the exudate are some pus, interstitial fluid, and some necrotic tissues and cells. Therefore, in the care of chronic exudative wounds, in addition to fully absorbing wound exudat...

AI Technical Summary

Problems solved by technology

Although the use of ionic silver-containing dressings with low water solubility can continuously release silver ions, the amount of silver ions released after contact with water is relatively small, so a relatively large amount of silver compounds is still required to achieve the desired antibacterial effect

In addition, the silver release performance of this type of wound dressing is average. Based on the calculation of 1% silver content, the 24-hour silver release in 10ml wound simulation fluid is only about 20ppm, which affects its antibacterial effect and function to a certain extent. time, in addition to this, most ionic silver dressings are not very stable, and the silver dressings will change color after a period of time, which affects its appearance acceptability as a commodity

[0007] In addition, there are currently studies using silver-containing complexes as antibacterial agents, such as silver thiosulfate complexes and silver-ammonia complexes, but these silver-containing complexes are a type of inorganic chelate with good solubility in water. The solubility in organic solvents such as ethanol is poor, which is quite unfavorable for products that will gel when exposed to water, such as carboxymethyl cellulose fiber products, carboxyethyl cellulose fiber products and acylated chitosan fibers products

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