Novel silver-containing antibacterial product, and preparation method thereof

A product, silver ion technology, applied in the direction of medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulations, etc., can solve the problem of less silver ion release, unfavorable glue products, unstable ionic silver-containing dressings, etc. question

Inactive Publication Date: 2017-09-15
FOSHAN UNITED MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the use of ionic silver-containing dressings with low water solubility can continuously release silver ions, the amount of silver ions released after contact with water is relatively small, so a relatively large amount of silver compounds is still required to achieve the desired antibacterial effect
In addition, the silver release performance of this type of wound dressing is average. Based on the calculation of 1% silver content, the 24-hour silver release in 10ml wound simulation fluid is only about 20ppm, which affects its antibacterial effect and function to a certain extent. time, in addition to this, most ionic silver dressings are not very st

Method used

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  • Novel silver-containing antibacterial product, and preparation method thereof
  • Novel silver-containing antibacterial product, and preparation method thereof
  • Novel silver-containing antibacterial product, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Preparation of silver-containing alcoholamine chelate solution with a molar ratio of ethanolamine to silver ion (silver acetate) of 2:1:

[0086] (1) Dilute 0.32ml of ethanolamine (16.6mol / L) with 30ml of absolute ethanol to obtain an ethanol solution of ethanolamine;

[0087] (2) weigh the silver acetate powder of 0.46g;

[0088] (3) Slowly add the above-mentioned ethanolamine solution to the silver acetate with a rubber dropper, and stir while adding, until the silver acetate dissolves to obtain a silver-containing ethanolamine chelate solution, and leave it to stand to obtain a colorless transparent solution;

[0089] The above preparation process is carried out at normal temperature.

Embodiment 2

[0091] Preparation of silver-containing alcoholamine chelate solution with a molar ratio of ethanolamine to silver ion (silver acetate) of 2:1:

[0092] (1) Dilute 1.62ml of ethanolamine (16.6mol / L) with 300ml of absolute ethanol to obtain an ethanol solution of ethanolamine;

[0093] (2) weigh the silver acetate powder of 2.3g, and be dispersed in 50ml dehydrated alcohol, form suspension;

[0094] (3) Slowly add the above-mentioned silver acetate suspension to the ethanol solution of ethanolamine, stir while adding, until the silver acetate dissolves to obtain a silver-containing ethanolamine chelate solution, and leave it to stand to obtain a colorless transparent solution;

[0095] The above preparation process is carried out at normal temperature.

Embodiment 3

[0097] Preparation of silver-containing alcoholamine chelate solution with a molar ratio of ethanolamine to silver ion (silver carbonate) of 2:1:

[0098] (1) Dilute 15.6ml of ethanolamine (16.6mol / L) with 300ml of absolute ethanol to obtain an ethanol solution of ethanolamine;

[0099] (2) weigh the silver carbonate powder of 7.6g;

[0100] (3) The above-mentioned ethanolamine solution is slowly added in the silver carbonate with a plastic head dropper, and stirred while adding, until the silver carbonate dissolves to obtain a silver-containing ethanolamine chelate solution, and leave standstill to obtain a colorless transparent solution;

[0101] The above preparation process is carried out at normal temperature.

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Abstract

The invention relates to a novel silver-containing antibacterial product, and a preparation method thereof. The novel silver-containing antibacterial product contains a silver-containing alcohol amine chelate as an antibacterial component; the silver-containing alcohol amine chelate is uniformly distributed in, and is combined with the internal part and/or the surface of the novel silver-containing antibacterial product. The novel silver-containing antibacterial product contains, by weight, 0.01 to 10% of silver, and the moisture absorption capability of the novel silver-containing antibacterial product is higher than 6g/g. The invention also provides a preparation method of the novel silver-containing antibacterial product, and a silver-containing dressing prepared from the novel silver-containing antibacterial product. The antibacterial spectrum of the novel silver-containing antibacterial product is wide; the novel silver-containing antibacterial product possesses high antibacterial activity on Gram-negative bacteria and Gram-positive bacteria, and light stability; effect is achieved quickly; and the novel silver-containing antibacterial product can be widely used for chronic infective wounds.

Description

technical field [0001] The invention relates to a silver-containing antibacterial product and a preparation method thereof, in particular to a silver-containing product containing a silver-containing alcoholamine chelate. The article can be used in medical dressings and other antimicrobial fields. Background technique [0002] With the improvement of people's living standards and changes in eating habits, the human disease spectrum presents some new features. Chronic exudative wounds such as venous ulcers, arterial ulcers, diabetic ulcers, traumatic ulcers, and pressure ulcers caused by diabetes, pressure sores, decubitus ulcers, and hypertension have seriously affected people's health. Exudative wounds are a type of chronic wounds that secrete a large amount of exudate, and the main components of the exudate are some pus, interstitial fluid, and some necrotic tissues and cells. Therefore, in the care of chronic exudative wounds, in addition to fully absorbing wound exudat...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K31/28A61P31/04A61L15/18A61L15/44A61L15/46
CPCA61K33/38A61L15/18A61L15/44A61L15/46A61L2300/104A61L2300/404
Inventor 冯彩霞陶炳志王晓东王锐
Owner FOSHAN UNITED MEDICAL TECH
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