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Application of acankoreanogenin to preparation of medicines for treating diabetes

A kind of diabetes medicine, the technology of salicylate, applied in the field of medicine, can solve the problem of unreported pharmacological effects and the like

Inactive Publication Date: 2017-09-26
CHANGSHA BROAD OCEAN BIO SCI & TECHN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects of argentica aglycone for treating diabetes have not been reported. The present invention, through a large number of experimental studies, has discovered the application of argentica aglycone in the preparation of medicines for treating diabetes.

Method used

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  • Application of acankoreanogenin to preparation of medicines for treating diabetes
  • Application of acankoreanogenin to preparation of medicines for treating diabetes
  • Application of acankoreanogenin to preparation of medicines for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 The preparation of arganica aglycone tablet

[0012] prescription:

[0013]

[0014]

[0015] Operation: Weigh the prescribed amount of argentica aglycone, sugar powder, lactose and sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add 3% PVPK30 aqueous solution to make a soft material, granulate with a 20-mesh sieve, and dry at 60°C 3 hours, 18 mesh sieve granules, add the prescribed amount of magnesium stearate, mix well and then compress into tablets, about 200mg per tablet, to obtain.

Embodiment 2

[0016] Example 2 Preparation of Aranthaglycoside Capsules

[0017] prescription:

[0018]

[0019] Operation: Weigh the prescribed amount of argentica aglycone and sodium carboxymethyl starch, mix well and make soft capsules, about 200 mg per capsule, to get ready.

Embodiment 3

[0020] Example 3 The in vitro inhibitory effect of argentinagenin on the activity of α-glucosidase

[0021] Improvements were made on the basis of the Bhandari method: Take 100 μL of pH 6.8 phosphate buffer solution, add 30 μL of α-glucosidase (0.25 U) and 150 μL of the sample solution to be tested, and use acarbose as a positive control. After thorough mixing, the samples were incubated at 37 °C for 15 min, and then 100 μL of 5 mM 4-nitrophenol-α-D-glucopyranoside (pNPG) solution was added to the reaction system, and the mixture was further incubated at 37 °C. Incubate for 25min. By adding 300 μL 0.1M Na 2 CO 3 Stop the reaction. The amount of released glucose was determined by the glucose oxidase method and the absorbance was measured at 405 nm. Take the arganateenin tablets and arganateenin capsules of Examples 1-2 to prepare sample solutions to be tested respectively, and each sample solution to be tested is prepared in parallel three times at the same time, and the av...

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Abstract

The invention provides novel pharmaceutical application of acankoreanogenin, in particular to application of acankoreanogenin to preparation of medicines for treating diabetes and further provides a pharmaceutical composition with acankoreanogenin serving as an active component. The acankoreanogenin is capable of inhibiting alpha-glucosidase activity to lower the blood glucose level of mice with spontaneous obesity diabetes and is widely applicable to preparation of the medicines for treating diabetes.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of medicine, in particular to the application of argentica aglycone in the preparation of medicines for treating diabetes. Background technique [0002] Diabetes mellitus is a complex disease characterized by persistent high blood sugar as its basic biochemical feature. It is mainly due to the disorder of glucose metabolism caused by the relative or absolute deficiency of insulin in the body. Long-term hyperglycemia in diabetic patients can produce various complications. Drugs clinically used to treat type II diabetes are mainly divided into (1) insulin and analogues; (2) oral hypoglycemic drugs: mainly sulfonylureas, biguanides, α-glucose inhibitors and insulin sensitizers, etc. drug. The efficacy of western medicine in treating diabetes is worthy of recognition. However, all kinds of western medicine hypoglycemic drugs have side effects such as gastrointestinal reacti...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/10
CPCA61K31/56
Inventor 邹亲朋戴玲杨阳
Owner CHANGSHA BROAD OCEAN BIO SCI & TECHN CO LTD
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