Application of crebzf in the treatment, prevention and diagnosis of metabolic diseases

Abstract

In this paper, by constructing a mouse model of liver-specific knockout of CREBZF, it was found that liver-specific knockout of CREBZF significantly slowed down the weight gain of mice induced by a high-fat and high-sugar diet, lowered blood sugar and blood lipids, improved liver fat deposition in mice, and increased glucose tolerance. Receptivity, slow down lipid accumulation in liver cells. Therefore, this article relates to the application of CREBZF in the treatment, prevention and diagnosis of metabolic diseases. Specifically, this paper provides the following reagents in the preparation of slowing down the weight gain of the subject, lowering the blood glucose and blood lipids of the subject, improving the fat deposition in the liver of the subject, increasing the glucose tolerance of the subject, and / or slowing down the purposes of the medicine of the object's liver cell lipid accumulation: ( 1) an agent that reduces expression of a CREBZF protein in a subject; and / or (2) an agent that reduces the activity of a CREBZF protein expressed in a subject.

Description

technical field [0001] The present invention relates to the application of CREBZF in the treatment, prevention and diagnosis of metabolic diseases. Background technique [0002] With the improvement of modern people's living standards and changes in dietary structure, the incidence of metabolic syndrome (MS) represented by obesity, type 2 diabetes, fatty liver, hyperglycemia, and hyperlipidemia is increasing year by year and presenting On the rise, hyperlipidemia due to fat metabolism disorder is the main cause of other chronic diseases such as fatty liver, obesity, coronary heart disease and atherosclerosis. Therefore, finding drug targets that can effectively prevent and control metabolic disorders has important practical significance for the prevention and treatment of metabolic diseases. The molecular indicators related to the metabolic syndrome represented by the above will play a positive role in the clinical molecular diagnosis, treatment and prevention of the diseas...

AI Technical Summary

Problems solved by technology

Preliminary studies on the function of CREBZF in biochemical molecules have been carried out before [Xie, Y.-B., B.Nedumaran and H.-S.Choi, Molecular characterization of SMILE as novel corepressor of nuclear receptors. Nucleic Acids Research, 2009.37( 12): p.4100-4115; Xie, Y.-B., etc., Transcriptional Corepressor SMILE RecruitsSIRT1toInhibit Nuclear Receptor Estrogen Receptor-related ReceptorγTransactivation.Journal of Biological Chemistry, 2009.284(42):p.28762-28774F], but for CREBZ Mechanisms of how metabolism is regulated under conditions of excess nutrition are poorly understood

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