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Application of spleen-invigorating preparation in increase of activities of ethanol dehydrogenase and acetaldehyde dehydrogenase

A technology of acetaldehyde dehydrogenase and alcohol dehydrogenase, which is applied to the application field of spleen-guiding preparations in improving the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase, and can solve the problem of insignificant effects, accelerate alcohol metabolism, and have no solution. Alcohol use, etc.

Inactive Publication Date: 2017-10-24
ZHEJIANG ASEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the anti-alcoholic medicines currently on the market only contain stimulants, vitamins and amino acids, which only provide some effects of comfort, sobriety, and headache relief, but have no actual anti-alcoholic effect or the effect is not obvious. Some anti-alcohol products are mainly made of traditional Chinese medicine materials such as kudzu flower, kudzu root, ganoderma lucidum, and isatid root. The main mechanism of action is to protect the liver by scavenging free radicals through anti-oxidation. After absorption in the body, it may accelerate the metabolism of ethanol in the body. Therefore, the effect is relatively slow
Most of the anti-alcoholic medicines on the market are taken after drunkenness, which is actually a bad policy, because at this time, the excess alcohol has entered the liver, causing the liver to reduce the synthesis of glycogen and promote the accumulation of fat, which will form fatty liver, which is harmful to the human body. caused damage

Method used

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  • Application of spleen-invigorating preparation in increase of activities of ethanol dehydrogenase and acetaldehyde dehydrogenase
  • Application of spleen-invigorating preparation in increase of activities of ethanol dehydrogenase and acetaldehyde dehydrogenase
  • Application of spleen-invigorating preparation in increase of activities of ethanol dehydrogenase and acetaldehyde dehydrogenase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021]

[0022] The above eleven flavors were crushed or chopped into suitable granules, extracted twice with water with a slight boiling dynamic reflux, the first time was added 10 times the amount of water for 1 hour, the second time was added with 5 times the amount of water for 0.5 hours, and the liquids were combined, filter. The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.05-1.15 (50° C.), filtered, and an appropriate amount of dextrin is added to the filtrate and mixed to prepare 1000 g of particles.

Embodiment 2

[0024]

[0025] The above eleven flavors were crushed or chopped into suitable granules, extracted twice with water with a slight boiling dynamic reflux, the first time was added 10 times the amount of water for 1 hour, the second time was added with 5 times the amount of water for 0.5 hours, and the liquids were combined, filter. The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.05-1.15 (50° C.), filtered, and an appropriate amount of dextrin is added to the filtrate and mixed to prepare 1000 g of particles.

Embodiment 3

[0027]

[0028] The above eleven flavors were crushed or chopped into suitable granules, extracted twice with water with a slight boiling dynamic reflux, the first time was added 10 times the amount of water for 1 hour, the second time was added with 5 times the amount of water for 0.5 hours, and the liquids were combined, filter. The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.05-1.15 (50°C), filtered, and an appropriate amount of water, honey, and dextrin is added to the filtrate, mixed well, pan-made into 1,000 pills, and dried.

[0029] 2. Drug efficacy test

[0030] Effects of Guipi Preparation on Activity of Alcohol Dehydrogenase and Aldehyde Dehydrogenase

[0031] 1. Experimental animals

[0032] ICR mice, weighing 20-22g

[0033] 2. Experimental method

[0034] 60 ICR mice, half male and half male, were randomly divided into 4 groups, namely the model control group, the high and low dose groups of Example 1, and the...

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Abstract

The invention relates to application of a spleen-invigorating preparation in increase of activities of ethanol dehydrogenase and acetaldehyde dehydrogenase, belonging to the technical field of traditional Chinese medicines. According to the spleen-invigorating preparation, the activities of ethanol dehydrogenase and acetaldehyde dehydrogenase can be effectively increased, so that the metabolism of ethanol is accelerated, purposes of alleviating hangover and protecting livers are achieved, and the toxic action of ethanol to a human body is alleviated; and the spleen-invigorating preparation is medical and edible, can be taken for a long time and has no toxic and side effects to the human body.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the application of a spleen-guiding preparation in improving the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. technical background [0002] With the development of social economy and the improvement of people's living standards, as well as the influence of alcohol culture in our country, drinking alcohol has become very common in our country, but a lot of drinking can cause nausea, vomiting, memory loss, inability to concentrate, and even in severe cases. Death due to respiratory muscle paralysis. Long-term drinking can cause mental disorders, gastric ulcers, alcoholic liver, fatty liver, liver cirrhosis and other diseases. Heavy drinking has become one of the important factors affecting human health in today's society. There are several ways to get rid of alcohol. One is to use gastrointestinal absorption inhibitors to inhibit the ga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P39/02A61P1/16
CPCA61K36/076A61K36/232A61K36/284A61K36/285A61K36/344A61K36/481A61K36/484A61K36/69A61K36/725A61K36/77A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 邓金明吴海英
Owner ZHEJIANG ASEN PHARMA
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