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A stable polypeptide composition and its application

A polypeptide composition and a stable technology, applied in the field of polypeptide raw material preparation, can solve the problems of easy generation of impurities, difficulty in formulating subsequent preparations, affecting the efficacy of use, etc., and achieve the effects of good safety, not easy inactivation, and stable structure

Active Publication Date: 2020-11-27
ZHUHAI UNITED LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The researchers of the present invention found that after nonapeptide-1, acetyl hexapeptide-8, and acetyl octapeptide-3 are mixed with other polypeptides, impurities are easily produced during the raw material placement process, which leads to difficulties in the formulation of subsequent preparations and affects their efficacy.

Method used

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  • A stable polypeptide composition and its application
  • A stable polypeptide composition and its application
  • A stable polypeptide composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Preparation of Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 Composition 1

[0046] (1) The formula is as shown in Table 1:

[0047] Table 1

[0048] Acetyl Hexapeptide-8 10g Palmitoyl Pentapeptide-4 5g lipoic acid 2g Methionine 3g Caprylyl glycol 10g Phenoxyethanol 20g Tween 80 80g sodium hydroxide Adjust pH to 6.5 purified water Fixed weight to 1000g

[0049] (2) Preparation process: Add 80g of Tween-80 and 500g of purified water into the batching tank, and stir well. Add 5g of palmitoyl pentapeptide-4 and 10g of acetyl hexapeptide-8 in sequence, and after stirring and dissolving at 1000rpm, dissolve 2g of lipoic acid and 3g of methionine with 300g of purified water, add them to the batching tank, and then add 10g of Xingan Alcohol, 20g phenoxyethanol, fully stir evenly. Finally, slowly drop 2mol / L sodium hydroxide solution into the formula reaction tank, increase the stirring rate to 15...

Embodiment 2

[0050] Example 2: Preparation of Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 Composition 2

[0051] (1) The formula is as shown in Table 2:

[0052] Table 2

[0053]

[0054]

[0055](2) Preparation process: Add 5g of Tween-80 and 500g of purified water into the batching tank, and stir well. Add 0.1g of palmitoyl pentapeptide-4 and 0.5g of acetyl hexapeptide-8 in turn, after stirring and dissolving at 1000rpm, dissolve 0.1g of lipoic acid and 0.1g of methionine with 300g of purified water, add them to the batching tank, and then Add 0.5g caprylyl glycol, 4.5g phenoxyethanol, fully stir evenly. Finally, slowly drop 2mol / L sodium acetate solution into the formula reaction tank, increase the stirring rate to 1500rpm, adjust the pH to 5.5, and then use purified water to set the weight to 1000g. Sterile PES membrane filtration, the solution is clear and transparent.

Embodiment 3

[0056] Example 3: Preparation of Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 Composition 3

[0057] (1) The formula is as shown in Table 3:

[0058] table 3

[0059] Acetyl Hexapeptide-8 0.5g Palmitoyl Pentapeptide-4 0.1g Carnosine 10g cysteine 40g Phenoxyethanol 8g glycerin 2g Tween 80 8g Sodium carbonate Adjust pH to 6.0 purified water Fixed weight to 1000g

[0060] (2) Preparation process: Add 8g of Tween-80 and 500g of purified water into the batching tank, and stir well. Add 0.1g of palmitoyl pentapeptide-4 and 0.5g of acetyl hexapeptide-8 in turn, and continue stirring at 1000rpm to dissolve, then dissolve 10g of carnosine and 40g of cysteine ​​with 300g of purified water, add them to the batching tank, and then add 2g of glycerin , 8g of phenoxyethanol, fully stirred evenly. Finally, slowly drop 2mol / L sodium carbonate solution into the formula reaction tank, increase the stirring rate to 1500rpm, ...

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Abstract

The invention discloses a stable polypeptide composition and application thereof. The polypeptide composition consists of sulfhydryl-containing polypeptides, water-insoluble polypeptides, a solubilizer, a stabilizing agent, a preservative, water and a pH value regulating agent. The invention is a result unexpectedly discovered by an inventor that when the stabilizing agent and the preservative simultaneously exist, the problem of easiness in impurity generation in the raw material placing process of a mixed aqueous solution of the sulfhydryl-containing polypeptides and the water-insoluble polypeptides is better solved; the prepared polypeptide composition is good in raw material quality, photo-stable, capable of placement for a long term at a room temperature and easy for the preparation of a subsequent preparation.

Description

technical field [0001] The invention belongs to the technical field of preparation of polypeptide raw materials, and in particular relates to a stable polypeptide composition and its application. Background technique [0002] Polypeptide is a kind of biologically active substance that is condensed by two or more amino acids and connected by peptide bonds. It is an intermediate product of protein, and its molecular structure is between amino acid and protein. In organisms, these active biological polypeptides not only exist in the form of polypeptide molecular structure and natural conformation, but also play important biological effects in the body in the form of natural biological activity, and play a role in the growth, development and metabolism of organisms. important biological role. In the defense and care of natural skin aging, such as proliferation of skin tissue cells, cell chemotaxis and migration, repair and regeneration, angiogenesis and reconstruction, pigment ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61Q19/00A61K38/08A61K38/07A61P17/00A61K8/34A61K8/37A61K8/42A61K8/44A61K8/46A61K8/67A61K8/63A61K8/23A61K47/02A61K47/10A61K47/18A61K47/20A61K47/22A61K47/46A61K8/35
CPCA61K8/23A61K8/345A61K8/347A61K8/35A61K8/37A61K8/42A61K8/44A61K8/463A61K8/64A61K8/676A61K8/678A61K8/97A61K38/07A61K38/08A61K47/02A61K47/10A61K47/18A61K47/183A61K47/20A61K47/22A61K47/46A61K2800/10A61K2800/5922A61Q19/00A61K2300/00
Inventor 杨祺周翠曹春来黄有泉许文威王康钊安鹏飞黄振彪
Owner ZHUHAI UNITED LAB