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Peptide regulating sebum secretion and cosmetics containing same

A technology of sebum secretion and cosmetics, applied in the field of non-natural peptides, can solve problems such as dry and cracked skin, affecting patients' work and life, and drug resistance

Active Publication Date: 2020-06-26
温州千瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Acne, oily hair, dandruff, and seborrheic dermatitis are not serious health problems, but they will have a major adverse impact on personal image, cause serious psychological burden to patients, and seriously affect their work and life. Addressing issues such as acne, oily hair, dandruff, seborrheic dermatitis is important for personal health and social development
At present, drugs or cosmetics containing antibiotics or hormones are often used for treatment, but these drugs often bring irritation and some adverse effects to the skin during treatment. Short-term treatment often rebounds after stopping the drug, and long-term use leads to chapped skin and even drug resistance

Method used

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  • Peptide regulating sebum secretion and cosmetics containing same
  • Peptide regulating sebum secretion and cosmetics containing same
  • Peptide regulating sebum secretion and cosmetics containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The test of peptide of the present invention inhibiting sebum secretion

[0065] 1. Isolation and primary culture of human sebocytes

[0066] Fresh head skin samples of normal people were washed once with PBS and 70% alcohol in sequence, and placed in In culture medium (plus 2% fetal bovine serum, antibiotic mixture). Subcutaneous fat was removed, the skin was cut into 0.5cm×0.5cm size, neutral protease was added, sealed and placed in a refrigerator at 4°C overnight. Peel off the epidermis under a stereo microscope, separate more than 15 sebaceous glands with tweezers, and place them in a collagen-coated cell culture dish (a cell culture dish with a diameter of 6 cm) The culture medium is not more than 1.5mL), placed in a 5% CO2 cell incubator, and cultured at 37°C for 2-3 days. After the sebocytes are fixed, replace Culture medium (add 10% fetal bovine serum, 5 μg / L recombinant human EGF, and antibiotic mixture to each bottle of culture medium), culture in a 5% ...

Embodiment 2

[0074] Embodiment 2: the preparation of blank cosmetics

[0075]

[0076]

Embodiment 3

[0077] Embodiment 3: the preparation of cosmetics

[0078] Element Content (weight%) Peptide of the invention (SEQ ID NO: 1) 0.001 Retinol 3.0 Forsythia Fruit Extract 1.5 Danshen Extract 1.5 Anemarrhena Extract 3.0 White Willow Bark Extract 5.0 1,3 propanediol 3.0 Sophora flavescens extract 5.0 Soy Lecithin 3.0 Dextran 3.0 Nicotinamide 1.0 ethyl lauroyl arginate 3.0 purified water Residual amount total 100

[0079] Dissolve dextran in purified water, add 1,3 propylene glycol, stir evenly, add other components, stir and prepare a beauty cream.

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PUM

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Abstract

The invention relates to an active peptide capable of adjusting sebum secretion and a cosmetic containing the active peptide. Particularly, the invention discloses peptides respectively represented by SEQ ID NO:1 and SEQ ID NO:2 which are independently used for or combined for adjusting the sebum secretion activity and the cosmetic containing the peptides. The cosmetic contains the following components in percentage by weight: 2.0%-4.0% of retinol, 0.5%-2.5% of a fructus forsythia fruit extract, 0.5%-2.5% of a radix salviae miltiorrhizae extract, 2.0%-4.0% of a rhizoma anemarrhenae extract, 4.0%-6.0% of a white willow bark extract, 2.0%-4.0% of 1,3-propylene glycol, 4.0%-6.0% of a radix sophorae flavescentis extract, 2.0%-4.0% of soybean lecithin, 2.0%-4.0% of glucan, 1.0%-2.0% of nicotinamide and 2.0%-4.0% of ethyl lauroyl arginate. The cosmetic has the efficacies of inhibiting sebum secretion, treating acnes and the like.

Description

technical field [0001] The present invention relates to non-natural peptides having a sebum secretion regulating effect and their use in cosmetic and personal care compositions. Background technique [0002] Normal skin contains hair follicles, sebaceous glands, sweat glands and other appendage structures. Sebaceous gland (sebaceous gland) is an important appendage structure in the skin, mostly located between the hair follicle and the arrector pili muscle, and is a vesicular gland composed of one or several cystic acini and a common short duct; the duct is stratified and flat The epithelium mostly opens on the upper part of the hair follicle, and some directly open on the skin surface. The distribution of sebaceous glands spreads all over the skin except the palms and soles of the feet. The secretion of sebaceous glands is sebum, which is a mixture of 1,3 propylene glycol triester, fatty acid, wax ester, sterol ester and other lipids. It has the functions of moisturizing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K8/64A61K8/34A61K8/44A61K8/55A61K8/67A61K8/73A61K8/9789A61Q19/00
CPCA61K8/345A61K8/44A61K8/553A61K8/64A61K8/671A61K8/675A61K8/73A61K8/97A61Q19/008C07K7/06
Inventor 罗海哨余作取
Owner 温州千瑞生物科技有限公司
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