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Application of stephania hainanensis extract in preparation of preparation used for treating gouty arthritis

A kind of gouty arthritis, Hainan intolerant technology, applied in the field of natural medicinal chemistry and medicine, can solve problems such as no reports on pharmacodynamics, and achieve the effect of remarkable therapeutic effect, simple preparation method and reducing spleen body index.

Inactive Publication Date: 2017-11-14
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are very few pharmacological studies on Hainan Dirong, and most of them are only HPLC or spectral analysis of its alkaloid components, and there are no reports on its pharmacodynamics

Method used

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  • Application of stephania hainanensis extract in preparation of preparation used for treating gouty arthritis
  • Application of stephania hainanensis extract in preparation of preparation used for treating gouty arthritis
  • Application of stephania hainanensis extract in preparation of preparation used for treating gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of the extract of Hainan groundwater

[0033] Weigh 1kg of the medicinal material of Hainan chinensis, crush it and put it in a container, add 10-20L of distilled water to the container, heat it to boiling for 2 hours, and filter it while it is hot to obtain 25g of the water extract of Hainan chinensis.

Embodiment 2

[0035] Take 5 kg of Hainan Rhizoma chinensis medicinal material, pulverize it, extract it with an ethanol solution with a volume concentration of 70-95% under heat reflux (25 L x 3 times), combine the extracts, concentrate until there is no alcohol smell to obtain an ethanol extraction concentrate (2 L), dry it, Obtain 90g of the ethanol extract of Hainan Rhizoma.

Embodiment 3

[0037] Take 5 kg of Hainan Rhizoma chinensis medicinal material, crush it, extract it with ethanol solution with a volume concentration of 70-95% under heat reflux (25 L × 3 times), combine the extracts, concentrate until there is no alcohol smell to obtain an ethanol extraction concentrate (2 L), and dilute the obtained ethanol The extract concentrate was diluted to 10L with water, extracted successively with petroleum ether (3L×3 times) and water-saturated n-butanol (5L×3 times), and concentrated under reduced pressure to obtain petroleum ether extract (50g) and n-butanol extract respectively. material (105g).

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Abstract

The invention relates to the technical fields of natural pharmaceutical chemistry and medicines and discloses application of a stephania hainanensis extract in preparation of a preparation used for treating gouty arthritis. The stephania hainanensis extract can obviously reduce joint swelling degree of a gouty arthritis rat, reduce a rat spleen index and lower levels of rat leukocytes, neutrophile granulocytes and lymphocytes, uric acid level in rat blood is also obviously lowered, and therapeutic effect on the gouty arthritis is obvious. The stephania hainanensis extract can be directly used and also can be used after being added with corresponding auxiliary materials and prepared into a preparation in a certain dosage form.

Description

technical field [0001] The invention relates to the technical fields of natural medicine chemistry and medicine, in particular to the application of the extract of Hainan Rhizoma hainan in the preparation of preparations for treating gouty arthritis. Background technique [0002] Gout is a hyperuricemia disease caused by purine metabolism disorder. The cause of the disease is due to the excessive accumulation of uric acid in the body, which is deposited on the bones and cartilage of the joints. More than half of the patients first developed at the first metatarsal joint, and typical gouty arthritis occurred. According to statistics, among patients with gouty arthritis, the incidence rate of middle-aged men is significantly higher than that of women. Moreover, the onset of the disease is sudden, and severe cases may wake up at night with pain. During the onset, local joint swelling, dark red skin, obvious tenderness, dare not move. The intermittent period of onset can las...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/59A61P29/00A61P19/02A61P19/06
CPCA61K36/59A61K2236/331A61K2236/333A61K2236/53
Inventor 张小坡金燕张彩云吴悠楠
Owner HAINAN MEDICAL COLLEGE
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