Acer truncatum bunge seed oil compound preparation with function of assisted memory improving, and applications thereof

A compound preparation, the technology of Yuanbao maple seed, applied in the field of compound preparation of Yuanbao maple oil and its preparation, can solve the problem of low content of nervous acid in the compound, achieve the effect of preventing sequelae of cerebral apoplexy, enhancing and assisting in improving memory

Inactive Publication Date: 2017-11-17
北京葆源医学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] 2. The existing Nervous Acid content of Yuanbao Maple Seed Oil compound is low, and it is far from enough to rely solely on the Nervous Acid content in Yuanbao Maple Seed Oil. Therefore, it is urgent to add DNA algae oil to increase the Nervous Acid content and enhance the effect of improving memory;

Method used

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  • Acer truncatum bunge seed oil compound preparation with function of assisted memory improving, and applications thereof
  • Acer truncatum bunge seed oil compound preparation with function of assisted memory improving, and applications thereof
  • Acer truncatum bunge seed oil compound preparation with function of assisted memory improving, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Formula and preparation process of compound preparation of Acer truncatum seed oil and zinc (the following are weight percentages)

[0040] 1) Preparation of Yuanbao Maple Seed Oil Soft Capsule

[0041] A: Acer truncatum seed oil 40%, DHA algae oil 10%, gelatin, glycerin, purified water. Specific preparation process: ingredients → melting glue → pelletizing → shaping → pill washing → low temperature and low humidity drying → pill picking → inner packaging → outer packaging → boxing → storage. (Sample batch number: 20160601)

[0042] B: Acer truncatum seed oil 50%, DHA algae oil 15%, gelatin, glycerin, purified water. Specific preparation process: ingredients → melting glue → pelletizing → shaping → pill washing → low temperature and low humidity drying → pill picking → inner packaging → outer packaging → boxing → storage. (Sample batch number: 20160602)

[0043] C: Acer truncatum seed oil 60%, DHA algae oil 20%, gelatin, glycerin, purified water. Specific preparat...

Embodiment 2

[0044] Example 2 Determination of Content of Acer Truncatum Seed Oil Compound Preparation

[0045] Take the reference solution and the samples prepared in the examples respectively, and use gas chromatography as the method for determining the content of nervonic acid and DHA, and high performance liquid chromatography as the method for determining the content of linoleic acid, oleic acid and vitamin E.

[0046] I. Determination of nervonic acid content by gas chromatography

[0047] 1) Gas chromatography conditions

[0048] Equipment and conditions: Agilent7890 headspace sampling series with FID detector

[0049] Capillary column: TR-FAME (100m×0.25mm, 0.2μm), column temperature program heating: initial temperature 150℃, keep 1min, heating rate 6℃ / min, final temperature 230℃, keep 20min; injector temperature 230 ℃, FID detector temperature 250℃; pre-column pressure 0.26MPa, split ratio 40:1, injection volume 1μL.

[0050] 2) Establish a standard working curve

[0051] Weigh 0.2000g of th...

Embodiment 3

[0079] Example 3 Auxiliary test for improving memory

[0080] The health food "Acer truncatum seed oil compound preparation" of the present invention has a beneficial effect on the memory acquisition disorder in mice by using the jumping method; improving the effect on the memory consolidation disorder in mice by avoiding the dark method; and reproducing the memory of mice The improvement effect of obstacles uses the water maze method.

[0081] A. Improvement of memory impairment in mice

[0082] 1. Animals: Kunming mice, weighing 18-22g.

[0083] 2. Experimental method

[0084] For the platform jumping test, 40 male mice weighing 18-22 g were selected and randomly divided into a blank control group and 6g / kg·bw, 8g / kg·bw, 10g / kg·bw, three test substance dosage groups, each with 10 Animals. The dose group was given the test substance by intragastric administration every day, and the sample was continuously administered for 30 days ("d" means the time "day", the same below), followed ...

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Abstract

The present invention provides an acer truncatum bunge seed oil compound preparation and applications thereof, wherein the acer truncatum bunge seed oil compound preparation comprises, by weight, 40-60% of acer truncatum bunge seed oil, and 10-20% of DHA algae oil. According to the present invention, the soft capsule can be prepared by adding the edible auxiliary material to the series compound preparation; and the matching combination is performed according to the functions and the characteristics of the components to form the compound preparation, and the obtained compound preparation has the assisted memory improving function.

Description

Technical field [0001] The invention belongs to the technical field of medical care and new drug development, and discloses a series of Acer truncatum seed oil compound preparations and a preparation method thereof, which have the function of assisting in improving memory. Background technique [0002] With the improvement of people's living standards, the pressure of life is increasing. The memory of the elderly decreases at a very slow rate with the aging of various organs. This is a natural law and a normal phenomenon. But now many young people have memory loss that is common to old people, which has to arouse our attention. Memory loss will cause things to be lost. Students will be distracted when going to school or adult work, unable to concentrate, and unable to concentrate on class or work, which affects normal work and study. If the memory is restored through drugs, it will also cause harm to the human body. [0003] Faced with the huge pressure of entering higher educati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/20A61K9/48A61P25/28A23D9/04A61K31/201A61K31/355A61K31/202
CPCA23D9/04A61K9/4866A61K31/201A61K31/202A61K31/355A61K36/20A61K2300/00
Inventor 崔红根
Owner 北京葆源医学研究院
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