Method for constructing miRNA (Micro Ribonucleic Acid) regulation and control network

A technology of regulating network and algorithm, applied in the field of data processing, can solve the problems such as the discovery method of regulation module without bipartite network, the failure to make good use of various sequencing data, etc., and achieve the effect of high reliability and reduction of cancer mortality.

Inactive Publication Date: 2017-11-21
XIDIAN UNIV
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, the problems existing in the existing technology are: there is no regulatory module discovery method specifically for bipartite networks, and the existing various sequencing data are not well utilized.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for constructing miRNA (Micro Ribonucleic Acid) regulation and control network
  • Method for constructing miRNA (Micro Ribonucleic Acid) regulation and control network
  • Method for constructing miRNA (Micro Ribonucleic Acid) regulation and control network

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0031] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0032] Such as figure 1 As shown, the method for constructing the miRNA regulatory network provided by the embodiments of the present invention includes:

[0033] S101: Apply linear regression to calculate the linear regression coefficient of mRNA and miRNA; use the linear regression coefficient of miRNA and its standard deviation to convert the linear regression coefficient of miRNA and mRNA into a T statistic; according to the T distribution, take the sample size D as the degree of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of data processing, and discloses a method for constructing a miRNA (Micro Ribonucleic Acid) regulation and control network. The method comprises the following steps that: applying linear regression to calculate the linear regression coefficient of mRNA (Messenger RNA) and miRNA, and calculating Z-score; taking the correlative probability of the miRNA-mRNA as the weight of an edge to establish an original miRNA and mRNA regulation and control network; through a ClusterONE clustering algorithm, clustering the miRNA regulation and control network to obtain an independent miRNA-mRNA cluster; clustering protein interaction network data through the ClusterONE clustering algorithm to obtain the miRNA-mRNA cluster; and optimizing the original miRNA and mRNA regulation and control network obtained previously by intersection data to generate a final regulation and control network. By use of the method, the identification efficiency of a miRNA and mRNA regulation and control relationship is guaranteed, and a basis is provided for the biological pathology of diseases.

Description

technical field [0001] The invention belongs to the technical field of data processing, and in particular relates to a method for constructing a miRNA regulation network. Background technique [0002] Bioinformatics is an emerging discipline combining life science and computer science. It collects, processes, stores, disseminates, analyzes and interprets biological information, and reveals complex biological data through the comprehensive use of biology, computer science and information technology. hidden biological mysteries. Due to the improvement of modern technology, people have been able to obtain the data of gene expression on the whole genome and the data of all miRNAs found so far, and the importance of miRNAs to the occurrence and development of tumors has been paid more and more attention. However, the current research on the miRNA regulatory network mainly has the following three major problems: (1) The miRNA regulatory network is a bipartite network, because the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18G06F19/22
CPCG16B30/00G16B20/00
Inventor 杨利英王大兵
Owner XIDIAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap