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R-spondin agonist-mediated hair growth

A spinal protein and agonist technology, applied in hair care, peptide/protein components, animal/human peptides, etc., can solve problems that have not been shown, stimulate, improve, etc.

Inactive Publication Date: 2017-11-28
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, despite its ubiquity, minoxidil does not perform in an entirely satisfactory manner in promoting hair growth in all target populations.
Although minoxidil has been shown to stimulate some hair growth in the apical region of the scalp, hair growth in the largest portion of the anterior region of the scalp has not been shown to be improved by treatment with minoxidil alone

Method used

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  • R-spondin agonist-mediated hair growth
  • R-spondin agonist-mediated hair growth
  • R-spondin agonist-mediated hair growth

Examples

Experimental program
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Effect test

Embodiment 1

[0174] Targeting hair follicle stem cells via R-spondin 2 to stimulate hair growth

[0175] Wnt signaling is involved in the development of the hair follicle and serves to initiate the growth phase (anagen phase) of the hair cycle. Using Axin2LacZ / + reporter mice and RNA analysis, it was confirmed that Wnt signaling is elevated during the growth phase (anagen) of the hair cycle. Endogenous Wnt signaling was amplified in the skin and surrounding hair follicles via intradermal injection of R-spondin 2 (Rspo2), and subsequently using Lgr5LacZ / + mice to demonstrate that this enhanced Wnt environment activates Lgr5 in hair follicles - Positive stem cells. Injection by Rspo2 inhibited the onset of the catagen phase (marked by cessation of cell proliferation and increased cell death) and allowed the anagen phase to continue. Therefore, hair growth becomes longer. Rspo2 can be used as a therapeutic protein to target hair follicle stem cells and promote hair growth.

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Abstract

Cosmetic skin and hair care compositions for enhancing the growth and appearance of mammalian hair in an individual are provided, which compositions comprise a dose of an R-spondin agonist effective to promote anagen phase of the hair cycle.

Description

[0001] cross reference [0002] This application claims the benefit of U.S. Provisional Patent Application Serial No. 62 / 101,712, filed January 9, 2015, and U.S. Provisional Patent Application Serial No. 62 / 275,742, filed January 6, 2016, each in its entirety incorporated herein by reference. Background technique [0003] Adult stem cells are pluripotent cells capable of executing specific differentiation programs in response to injury or key environmental signals. Many, if not all, adult organs have small numbers of stem cells, offering hope of regenerating the ability of organs lost to injury or disease. In many tissues, pluripotent stem cells are found within specific tissue niches of supporting cells. These niches contain specific extrinsic and intrinsic cues and function to provide regulatory signals that help the pattern tissue to self-renew, proliferate or differentiate. Although the relationship between stem cells and niches is known, regulating the control of inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P17/14A61K38/00C07K7/00C07K14/00A61K38/08
CPCC07K7/06C07K14/47A61K38/1709A61K8/64A61Q7/00A61K38/08A61P43/00A61K9/0019
Inventor J·赫尔姆斯G·R·达姆德赫雷A·E·奥罗A·A·史密斯A·阿博
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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