A diagnostic biomarker for colorectal cancer and its application

A biomarker, colorectal cancer technology, applied in biochemical equipment and methods, microbial determination/inspection, organic compound library, etc. High requirements and other problems, to achieve the effect of improving the 5-year survival rate, broad application prospects, and timely diagnosis
CN107447033BActive Publication Date: 2020-11-17SOUTHEAST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHEAST UNIV
Publication Date
2020-11-17

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Abstract

The invention relates to a colorectal cancer diagnostic biomarker and application thereof. A nucleotide sequence is shown as SEQ ID NO. 1. The colorectal cancer diagnostic biomarker provided by the invention has the beneficial effects that hsa_circ_0006110 gene expression is discovered to be closely related to a colorectal cancer for the first time; through detecting the expression of hsa_circ_0006110 in a subject colorectal tissue, whether a subject suffers from the colorectal cancer or the risk of the colorectal cancer exists or not can be more accurately and quickly judged, so that a prevention or treatment scheme is provided for a clinician. A target gene as a drug for treating the colorectal cancer provides a new treatment targets and treatment approach for colorectal cancer treatment; compared with a traditional detection means, the diagnostic biomarker is more timely and more specific to diagnose, so that the five-year survival rate of a colorectal cancer patient is improved, and the death rate is reduced, therefore, the application prospect is wide.
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Description

technical field

[0001] The invention belongs to the technical field of molecular biology, and in particular relates to a circular RNA hsa_circ_0006110 and its application as a marker in the diagnosis of colorectal cancer. Background technique

[0002] Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract, the third most common tumor in men and the second in women, and the second leading cause of cancer deaths. According to the International Agency for Research on Cancer of the World Health Organization, there were about 1.2 million new cases of colorectal cancer in the world in 2008, and its mortality rate accounted for about 8% of all malignant tumors. With the improvement of my country's economy and life in the past 30 years, the incidence and death of colorectal cancer in my country are on the rise, ranking third in the incidence of malignant tumors and fifth in death in my country, seriously threatening people's health and life . Colo...

Claims

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