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A method for the determination of 8 carbonyl compounds in mainstream smoke of heat-not-burn cigarettes

A technology for cigarette mainstream smoke and carbonyl compounds, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of low sensitivity and high detection limit, and achieve high sensitivity, avoid false positive phenomenon, and reduce pollution.

Active Publication Date: 2020-05-15
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to provide a method for measuring 8 kinds of carbonyl compounds in the mainstream smoke of heat-not-burn cigarettes, so as to solve the problem of low sensitivity and high detection limit of the method for measuring carbonyl compounds in the mainstream smoke of cigarettes in the prior art. Technical Problems in the Determination of Carbonyl Compounds in Mainstream Smoke of Combustion Cigarettes

Method used

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  • A method for the determination of 8 carbonyl compounds in mainstream smoke of heat-not-burn cigarettes
  • A method for the determination of 8 carbonyl compounds in mainstream smoke of heat-not-burn cigarettes
  • A method for the determination of 8 carbonyl compounds in mainstream smoke of heat-not-burn cigarettes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The determination method of 8 kinds of carbonyl compounds in the mainstream smoke of the heat-not-burn cigarette in this embodiment, such as figure 1 shown, including the following steps:

[0029] 1. Capture of samples

[0030] 1.1 Preparation of 2,4-dinitrophenylhydrazine derivatization reagent

[0031] Purification of 2,4-dinitrophenylhydrazine:

[0032] Weigh 35g of 2,4-dinitrophenylhydrazine (DNPH) solid in a 2L flask, add 750mL of absolute ethanol, slowly heat and shake, then slowly add 1000mL of ethyl acetate, continue to add ethyl acetate until DNPH Completely dissolved, the solution should be a clear dark red solution; vacuum filter the solution into a 2L flask, seal it and let it stand overnight to crystallize, vacuum filter the recrystallized DNPH, weigh it and store it in a sealed dry place, concentrate and pump Filtrate to get more recrystallized DNPH;

[0033] Preparation of 2,4-Dinitrophenylhydrazine Derivatization Reagent

[0034] Weigh 1.5 g of the ...

Embodiment 2

[0071] The main carbonyl compounds in the mainstream smoke of the heat-not-burn cigarette sample in Example 1 were measured by using deep smoking mode (HCI), and the measurement method was the same as in Example 1, wherein the volume fraction of pyridine in the acetonitrile solution of pyridine was 10%. , the results are shown in Table 6.

[0072] Table 6 Smoking detection results of main carbonyl compounds HCI in mainstream smoke of heat-not-burn cigarettes

[0073] compound Content (μg / cig) formaldehyde 20.8 Acetaldehyde 214.2 acetone 25.3 acrolein 6.3 Propionaldehyde 11.6 Crotonaldehyde 6.1 2-butanone 6.0 Butyraldehyde 18.2

experiment example

[0075] Sample in embodiment 1 is carried out high, middle and low different concentration level standard solution spiked recovery rate test, each sample is measured 5 times respectively, calculates the recovery rate of various main carbonyl compounds of this method and measured value after adding the standard The relative standard deviation of the results are shown in Table 7. It can be seen from Table 7 that the average recovery rate of the main carbonyl compounds in cigarette mainstream smoke detected by this method is between 83.5% and 90.5% at the three spiked levels. The average relative deviation of the sample test results is less than 6.7%, indicating that the recovery rate of the method is high and the repeatability is good.

[0076] Recovery and repeatability (n=5) of carbonyl compounds in table 7 cigarette mainstream smoke

[0077]

[0078]

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Abstract

The invention relates to a method for determining eight carbonyl compounds in heating non-combustible cigarette main flue gas, which belongs to the technical field of physical and chemical examination of cigarette main flue gas. The method comprises the following steps: extracting a filter disc used for capturing eight carbonyl compounds in the heating non-combustible cigarette main flue gas by employing a pyridine acetonitrile solution to obtain an extract, using high performance liquid chromatography-tandem mass spectrum for determination, and performing quantification by an internal standard method; wherein the carbonyl compounds are formaldehyde, acetaldehyde, acetone, acrolein, propionaldehyde, crotonaldehyde, 2-butanone, and butyraldehyde. The determination method is rapid and effective, and has the advantages of high sensitivity and low detection limit, average relative standard deviation is less than 6.7%, and the average recovery rate of the index is between 83.5% and 90.5%.

Description

technical field [0001] The invention relates to a method for measuring eight carbonyl compounds in mainstream smoke of heat-not-burn cigarettes, and belongs to the technical field of physical and chemical testing of mainstream smoke of cigarettes. Background technique [0002] Carbonyl compounds are an important class of harmful components in mainstream cigarette smoke, and are included in the list of 46 harmful components of the Canadian government and the list of controlled components recommended by the WHO "Tobacco Product Regulation Research Group", thus accurately determining the volatility of cigarette smoke Carbonyl compounds are of great significance to the hazard assessment of cigarettes. At present, the detection of carbonyl compounds in mainstream cigarette smoke in China generally adopts the high performance liquid chromatography method stipulated in "YC / T 254-2008". Phase chromatographic UV detectors have limited sensitivity and are not sensitive enough for the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 张洪非姜兴益朱风鹏罗彦波李翔宇庞永强胡少东赵银杰
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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