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Application of metronidazole as internal standard substance to H-nuclear magnetic resonance technology

A nuclear magnetic resonance and metronidazole technology, which is applied in the direction of using nuclear magnetic resonance for analysis, material analysis by resonance, and measurement devices, etc. Accurate measurement, simple hydrogen spectrum effect

Inactive Publication Date: 2017-12-22
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] At present, there are not many types of hydrogen quantitative NMR internal standards for traceability

Method used

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  • Application of metronidazole as internal standard substance to H-nuclear magnetic resonance technology
  • Application of metronidazole as internal standard substance to H-nuclear magnetic resonance technology
  • Application of metronidazole as internal standard substance to H-nuclear magnetic resonance technology

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Embodiment 1, the application of metronidazole in the proton magnetic resonance quantitative analysis of ethylparaben as internal standard

[0053] The ethylparaben is subjected to quantitative proton nuclear magnetic resonance analysis, and the present invention uses high-purity metronidazole as an internal standard in nuclear magnetic resonance quantitative technology.

[0054] Dissolve 10 mg of high-purity metronidazole and 12 mg of ethyl paraben in 1 mL of deuterated methanol solvent. After fully dissolving, pipette 0.80 mL into a quartz NMR tube for testing. Ethyl esters were dissolved in deuterated methanol as a reference sample to determine the assignment of chemical shifts. Metronidazole was dissolved in deuterated acetone and deuterated acetic acid to determine the assignment of chemical shifts to further confirm the accuracy.

[0055] The NMR experiment of the mixed sample of metronidazole and ethylparaben optimized the sampling time, sampling frequency, prob...

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Abstract

The invention discloses an application of metronidazole as an internal standard substance to an H-nuclear magnetic resonance technology. The specific application of metronidazole comprises at least one of the following 1)-3): 1) structural analysis of a to-be-detected compound; 2) qualitative analysis of the to-be-detected compound; 3) quantitative analysis of the to-be-detected compound. The purity of metronidazole is 99.8% plus or minus 0.4%, and applicable solvents refer to various deuterated solvents. High-purity metronidazole is taken as the internal standard substance, a hydrogen spectrum is simple, quantitative peak range is wider, metronidazole can be dissolved in various deuterated solvents and has the advantage of traceability, and the content of the to-be-detected substance can be determined stably and accurately.

Description

technical field [0001] The invention relates to the application of metronidazole as an internal standard in hydrogen nuclear magnetic resonance technology, belonging to the field of analytical chemistry and stoichiometric. Background technique [0002] Metronidazole is also known as Metronidazole, Nitroxetazole, etc., English name: metronidazole, CAS: 443-48-1. Molecular formula C 6 h 9 N 3 o 3 . The relative molecular weight is 171.15. White or off-white crystalline powder, milky white crystals obtained from ethyl acetate, melting point 158-160°C. Slight odor, slightly bitter and salty. Soluble in water, ethanol, chloroform, soluble in inorganic acids and other solvents. The molecular structural formula of metronidazole is shown in formula 1. [0003] [0004] Proton NMR has the characteristics of high sensitivity, high precision, rapidity and directness, and is widely used in the structural analysis and qualitative analysis of organic compounds. In recent year...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
CPCG01N24/08G01N24/087
Inventor 杨梦瑞王敏周剑
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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