Islet transplantation method

Abstract

The invention discloses a method for transplanting pancreatic islets. The method comprises the following steps: 1) placing a foreign body structure in liver parenchyma; 2) taking out the foreign body structure to form a liver sinus; 3) transplanting islets into the cavity of the liver sinus. The islet transplantation method disclosed in the present invention has the following advantages: the occurrence probability of complications such as portal venous hemorrhage, hepatic embolism, portal hypertension, and immediate blood-mediated inflammatory reaction (IBMIR) is low, and the operation is relatively simple; Concentrating on a certain lobe of the liver, the graft can be completely resected when needed, which is conducive to the tracking and monitoring of graft function and makes future cell replacement therapy safer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for islet transplantation. Background technique [0002] In recent years, with the improvement of people's living standards, population aging and lifestyle changes, the number of people with diabetes has increased rapidly. Diabetes mellitus is a disorder of glucose metabolism caused by lack of insulin secretion or dysfunction of pancreatic islets. The World Health Organization predicts that by 2025, diabetes patients worldwide will rise to nearly 300 million, and will be one of the five major diseases that threaten human health and life safety and have the highest morbidity and mortality. Diabetes is mainly divided into type 1 diabetes and type 2 diabetes, and type 1 diabetes is an autoimmune disease. The patient's immune system selectively destroys the insulin-secreting pancreatic islet β cells, resulting in an absolute lack of insulin, resulting in a series of me...

AI Technical Summary

Problems solved by technology

The ability to produce insulin in the body of patients with type 2 diabetes is not completely lost, and some patients even produce too much insulin in the body, but the effect of insulin is poor, so the insulin in the body of the patient is relatively deficient, which can be stimulated by some oral drugs Insulin secretion, but some patients still need to use insulin therapy in the later stage

[0005] 1. It may cause complications such as portal venous hemorrhage, hepatic embolism, portal hypertension, and immediate blood-mediated inflammatory response (IBMIR), resulting in a large number of grafts losing efficacy in the early stage of transplantation

[0006] 2. Islet transplantation through the portal vein, the grafts are scattered in the liver, which is not convenient for biopsy tracking and resection of the grafts, which limits the application of stem cell transplantation

[0007] In existing studies, in small animal models, the risk of portal vein cannulation bleeding is high, and liver embolism is more obvious after islet transplantation. 2016, 28(2): 129-132) reported that the mortality rate within 5 days after portal vein islet transplantation in mice was as high as 40%, which shows that it is difficult to establish a model of mouse islet transplantation through portal vein

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