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Uighur medicine compound for leucoderma and preparation method thereof

A kind of vitiligo and compound technology, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of large toxic and side effects, poor long-term curative effect, easy recurrence and aggravation, and achieve curative effect exact effect

Pending Publication Date: 2018-01-12
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the short-term curative effect of Western medicine is good, but the side effects are large, and it cannot be used for a long time.

Method used

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  • Uighur medicine compound for leucoderma and preparation method thereof
  • Uighur medicine compound for leucoderma and preparation method thereof
  • Uighur medicine compound for leucoderma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 (based on 1000ml, oral liquid is prepared)

[0026]a. Pulverize 50 parts of Tibetan fennel that has been screened, pass through a 10-mesh sieve, soak in water with a mass ratio of 20 times the amount for 4 hours, extract the volatile oil with a volatile oil extractor for 8 hours, and collect the volatile oil and water extract respectively;

[0027] b. Put 10 g of β-cyclodextrin into a round-bottomed flask, add 25 times the amount of distilled water, and stir to dissolve on a magnetic stirrer with a constant temperature of 50 ° C. The volatile oil in step a is mixed with absolute ethanol in a volume ratio of 1 :1 diluted, then slowly added to the β-cyclodextrin solution, continued to stir on a magnetic stirrer with a constant temperature of 50°C for 2 hours, cooled at room temperature, put it in the refrigerator for 24 hours, took it out, filtered it with petroleum ether (30-60°C) rinse 3 times, 10mL each time, dry in an oven at 50°C for 4 hours to obtain dr...

Embodiment 2

[0031] Embodiment 2 (based on 1000ml, prepare syrup)

[0032] a. Pulverize 20 parts of Tibetan fennel that has been screened, pass through a 50-mesh sieve, soak in water with a mass ratio of 10 times the amount for 5 hours, extract the volatile oil with a volatile oil extractor for 5 hours, and collect the volatile oil and water extract respectively;

[0033] b. Put 15g of β-cyclodextrin in a round bottom flask, add 25 times the amount of distilled water, and stir to dissolve on a magnetic stirrer with a constant temperature of 50°C. The volatile oil in step a is mixed with absolute ethanol in a volume ratio of 1 :1 diluted, then slowly added to the β-cyclodextrin solution, continued to stir on a magnetic stirrer with a constant temperature of 50°C for 2 hours, cooled at room temperature, refrigerated in the refrigerator for 24 hours, took it out, suction filtered, and clathrate Rinse with petroleum ether (30-60°C) 3 times, 10mL each time, and dry in an oven at 50°C for 4 hour...

Embodiment 3

[0037] Embodiment 3 (based on 1000ml, prepare syrup)

[0038] a. Crush 10 parts of Tibetan fennel that has been screened, pass through a 40-mesh sieve, soak in water with a mass ratio of 6 times the amount for 6 hours, extract the volatile oil with a volatile oil extractor for 3 hours, and collect the volatile oil and water extract respectively;

[0039] b. Put 15g of β-cyclodextrin in a round bottom flask, add 25 times the amount of distilled water, and stir to dissolve on a magnetic stirrer with a constant temperature of 50°C. The volatile oil in step a is mixed with absolute ethanol in a volume ratio of 1 :1 diluted, then slowly added to the β-cyclodextrin solution, continued to stir on a magnetic stirrer with a constant temperature of 50°C for 2 hours, cooled at room temperature, refrigerated in the refrigerator for 24 hours, took it out, suction filtered, and clathrate Rinse with petroleum ether (30-60°C) 3 times, 10mL each time, and dry in an oven at 50°C for 4 hours to ...

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Abstract

The invention relates to a Uighur medicine compound for leucoderma and a preparation method thereof. The compound is prepared from the following medicinal materials: herb of carum carvi, fructus psoraleae, puncture vine caltrop fruit, seed of ajowan-caraway, root of operculina turpethum; oral dosage forms such as oral liquid, syrup, granules, hard capsules and tablets are prepared by the methods of solvent extraction, impurity removal, concentration and drying and by adopting proper accessories. According to the Uighur medicine compound and the preparation method thereof provided by the invention, the Uighur medicine compound for leucoderma is prepared by a modern extraction method according to the theory of Uighur medicine and in combination with the characteristics of national medicinesand long-term civil clinical practice, the efficacy is enhanced, and the bioavailability is improved. In-vitro activity experiments indicate that different dosage forms of the Uighur medicine compoundfor leucoderma prepared by the method influence the morphology of mouse B16 melanoma cells to different degrees and realize a concentration dependence activation effect on the cell activity and the melanin synthetic quantity. Experimental results indicate that different dosage forms of the Uighur medicine compound for leucoderma all show very strong ability of activating B16 melanoma cells and promoting melanin formation and can be used for treating leucoderma.

Description

technical field [0001] The invention relates to a Uighur medicine compound for treating vitiligo and a preparation method thereof, and belongs to the technical field of Uighur medicine and ethnic medicine. Background technique [0002] Vitiligo is an acquired, progressive, multifactorial depigmentation complex disease of chronic epidermal melanocyte loss characterized by progressive loss of functional epidermal melanocytes. The pathogenesis of vitiligo has not yet been clarified. However, various pathogenic mechanisms have been proposed, including genetic associations, cellular and humoral autoimmunity, oxidative stress, neurohormonal imbalances, abnormalities in the microenvironment surrounding melanocytes, and intrinsic defects in melanocytes. At present, there are some reports that the global incidence rate of vitiligo is 0.5% to 1%, and there are also reports that the incidence rate in some parts of the world even reaches 8%. The prevalence of vitiligo was recently rep...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61K9/08A61K9/10A61K9/20A61K9/16A61K9/48A61K47/69A61P17/00
Inventor 阿吉艾克拜尔·艾萨阿布都吉力力·阿布都艾尼罗玉琴刘昌华徐建军希尔艾力·吐尔逊
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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