Oxaliplatin impurity C, and preparation method and application thereof
A technology for oxaliplatin and impurities is applied in the field of chemical synthesis, which can solve the problems of low yield and low purity, and achieve the effects of low preparation cost, simple preparation method and good economic and social benefits.
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Embodiment 1
[0043] (1) Oxidation Take 5.0g of oxaliplatin raw material, put it in a 3000mL measuring bottle, add 1000mL of water, and dissolve it by ultrasonic (power: 500W, frequency: 40kHz) for 10 minutes, and fill the bottle with excess oxygen at 30°C. Seal it, let it stand for 1 hour, and let it stand for 4 times with oxygen.
[0044] (2) Preparation of crude product Concentrate the above solution to 500mL under reduced pressure with a Buchi R210 rotary evaporator (temperature: 80°C, vacuum degree: 100mbar, rotation speed: 60 rpm), and evaporate to dryness on a water bath to obtain 5.52g of impurity C crude product .
[0045] (3) Recrystallization Take the crude product of impurity C, add 1000mL of water, heat to 80°C in a water bath, dissolve it with ultrasound (power: 500W, frequency: 40kHz) for 30 minutes, filter, and use Buchi R210 rotary evaporator for the filtrate (temperature: 80°C, vacuum Degree: 100mbar, rotation speed: 60 rpm) concentrated under reduced pressure to 400mL, pla...
Embodiment 2
[0049] (1) Oxidation Take 5.0g of oxaliplatin raw material, put it in a 3000mL measuring bottle, add 1000mL of water, and dissolve it by ultrasonic (power: 500W, frequency: 40kHz) for 10 minutes, and fill the bottle with excess oxygen at 30°C. Seal it, let it stand for 1 hour, and let it stand for 10 times with oxygen.
[0050] (2) Preparation of crude product Concentrate the above solution to 500mL under reduced pressure with a Buchi R210 rotary evaporator (temperature: 80°C, vacuum degree: 100mbar, rotation speed: 60 rpm), and evaporate to dryness on a water bath to obtain 5.5g of impurity C crude product .
[0051] (3) Recrystallization Take the crude product of impurity C, add 1000mL of water, heat to 80°C in a water bath, dissolve it with ultrasound (power: 500W, frequency: 40kHz) for 30 minutes, filter, and use Buchi R210 rotary evaporator for the filtrate (temperature: 80°C, vacuum Degree: 100mbar, rotation speed: 60 rpm) concentrated under reduced pressure to 400mL, p...
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