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Traditional Chinese medicine compound preparation for treating inflammatory bowel disease and preparation method thereof

A technology for inflammatory bowel disease and compound preparations, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., and can solve problems such as the lack of clear confirmation of the mechanism of ulcerative colitis.

Active Publication Date: 2018-01-16
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of traditional Chinese medicine in the treatment of ulcerative colitis has not been clearly confirmed.

Method used

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  • Traditional Chinese medicine compound preparation for treating inflammatory bowel disease and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating inflammatory bowel disease and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating inflammatory bowel disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] [Example 1] (tablet preparation of Chinese medicine compound preparation of the present invention)

[0168] Weigh 600g of S. chinensis, 500g of Pulsatilla, 400g of Patrinia, 500g of Cornus officinalis, 300g of Raw Astragalus, 200g of Radix Pseudostellariae, after appropriate drying, crush them, and pass through a 100-mesh sieve; weigh 200g of starch and add water to make a slurry; put the above raw material drug powder into In starch slurry, fully stirred evenly, granulated, dried, flaked, packaged, ready to be obtained.

Embodiment 2

[0169] [Example 2] (preparation of mixture of Chinese medicine compound preparation of the present invention)

[0170] Weigh 500g of S. chinensis, 400g of Pulsatilla, 300g of Patrinia, 300g of Cornus officinalis, 500g of Raw Astragalus, and 300g of Radix Pseudostellariae, decoct and extract by conventional method of traditional Chinese medicine preparation (300g of Radix Pseudostellariae is decocted separately), combine the decoctions, and let stand for precipitation , filter out insoluble matter, collect the filtrate, concentrate, add appropriate amount of commonly used preservatives, flavoring agents and bacteriostatic agents, subpackage, sterilize, and obtain.

Embodiment 3

[0171] [Example 3] (preparation of oral liquid of Chinese medicine compound preparation of the present invention)

[0172] Weigh 600g of Radix Pseudostellariae, extract by percolation; weigh 600g of Rhizoma Pulsatillae, 600g of Pulsatilla, 600g of Patrinia, 500g of Cornus officinalis, and 600g of Raw Astragalus, decoct and extract by conventional methods of traditional Chinese medicine preparations, combine the decoctions, and add appropriate amount of ethanol for precipitation , filtered; combine the percolation and decoction of Radix Pseudostellariae, recover ethanol, add appropriate amount of commonly used preservatives, flavoring agents and bacteriostatic agents, sub-package, sterilize, and obtain.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating inflammatory bowel disease. The traditional Chinese medicine compound preparation comprises the following bulkdrugs in parts by weight: 2-6 parts of sargentgloryvine stem, 2-6 parts of patrinia herb, 2-6 parts of pasque flower, 2-6 parts of raw radix astragali, 2-6 parts of pseudostellaria root, and 1-5 partsof Cornus officinalis. The above traditional Chinese medicine compound preparation can be prepared to tablets, a mixture, oral liquid, a particulate agent and capsules, and has the efficacy for supplementing Qi to warming Yang, and clearing heat and expelling toxin; and is mainly used for treating inflammatory bowel disease (ulcerative colitis and Crohn's disease) large intestine damp-heat, spleen and kidney yang-deficiency, and intestinal collateral blood stasis, and is especially suitable for improving mucopurulent bloody stool, stomachache, abdominal distension, diarrhea, and rectal tenesmus. The invention also discloses a method for preparing various dosage forms of the traditional Chinese medicine compound preparation.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine compound preparation for treating symptoms such as mucus, pus and blood in stool, abdominal pain, abdominal distension, diarrhea, tenesmus and a preparation method thereof for inflammatory bowel disease, in particular to a traditional Chinese medicine compound preparation prepared with traditional Chinese medicine as raw materials for treating inflammatory bowel disease and its preparation method. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific colonic inflammation whose etiology is not very clear. The lesions mainly involve the colonic mucosa and submucosa. The range mostly starts from the distal colon, and can develop retrogradely to the proximal segment, even involving the entire colon and the terminal ileum, showing a continuous distribution. The main clinical manifestations are diarrhea, abdominal pain and mucus, pus and blood in the stool. Crohn's di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P1/00A61K9/08A61K9/16A61K9/20A61K9/48A61K9/00
Inventor 陆金根潘一滨王佳雯曹永清王琛周唯
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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