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Dendrobium officinale oil dripping pill and preparation method thereof

A technology of Dendrobium officinale and Dendrobium oil, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems such as no patent report on Dendrobium officinale oil drop pills, etc. The effect of short cycle and stable product quality

Inactive Publication Date: 2018-01-16
东莞暨南大学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the other hand, the current domestic and foreign patents on Dendrobium candidum products are mainly granules, capsules, oral liquids or beverages made from raw materials of Dendrobium candidum, and there are no reports on patents related to Dendrobium candidum oil dripping pills.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the preparation of dendrobium officinale oil

[0027] The Dendrobium officinale oil that uses in the embodiment of the present invention obtains by following process:

[0028] Raw materials—crushing—weighing—charging—sealing—parameter setting—extraction under supercritical conditions—extraction.

[0029] Weigh an appropriate amount of stem material of Dendrobium officinale, grind it into a fine powder of 40-80 mesh, and use supercritical CO 2 Extraction device for extraction. Select 95% (volume) ethanol as the entrainer, the extraction temperature is 35-50°C, the extraction pressure is 20-40MPa, CO 2 The flow rate is 10-30L / h, and the extraction time is 30-150min. The extraction rate of the method is 1.5%-3.0%.

Embodiment 2

[0030] Embodiment 2: Taking PEG 6000 as the substrate to prepare Dendrobium candidum oil dripping pills

[0031] The dendrobium candidum oil dripping pill of the present embodiment is made through the following steps:

[0032] (1) Prepare the contents: Accurately weigh 60g of PEG 6000 in a heating vessel while heating and stirring until melting, measure 10mL of Dendrobium officinale oil and add it to the molten matrix, stir until the liquid is uniform, and set aside.

[0033] (2) Dropping: the medicinal liquid is formed through the dropper of the dropping pill machine and dropped into the liquid paraffin condensing agent. Keep the dripper temperature of the dropping pill machine at 75-80°C, the upper temperature of the cooling liquid in the condensation column is 35°C, the bottom temperature is 5°C, the temperature of the condensing agent is kept at 5-10°C, and the dropping speed is controlled at 30- 35 drops / min, the drop distance is 6cm.

[0034] (3) Collection: the drop p...

Embodiment 3

[0037] Embodiment 3: The mixture of poloxamer 188 and PEG6000 is used as matrix to prepare Dendrobium officinale oil drop pills

[0038] The dendrobium candidum oil dripping pill of the present embodiment is made through the following steps:

[0039] (1) Configuration content: Accurately weigh 25g of poloxamer and 25g of PEG 6000, heat and stir in a water bath at 80-90°C until melted, measure 10mL of Dendrobium candidum oil into the molten matrix, stir To a homogeneous medicinal solution, set aside.

[0040] (2) Dropping: the medicinal liquid is formed through the dropper of the dropping pill machine and dropped into the liquid paraffin condensing agent. Keep the dripper temperature of the dropping pill machine at 80-85°C, the upper temperature of the cooling liquid in the condensation column is 40°C, the bottom temperature is 7°C, the temperature of the condensing agent is kept at 5-10°C, and the dropping speed is controlled at 50- 55 drops / min, the drop distance is 6cm.

[...

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Abstract

The invention discloses a dendrobium officinale oil dripping pill and a preparation method thereof. The dendrobium officinale oil dripping pill is composed of dendrobium officinale oil and a matrix according to the volume-weight ratio of 1: 4 to 1: 9 mL: g. The matrix is at least one of PEG 6000, PEG 4000, PEG 10000, PEG 20000, glycerol, PEG 8000, poloxamer, insect wax, polysorbate 80 and sodium carboxymethyl starch. The invention provides a novel dosage form of dendrobium officinale. The novel dosage form has the characteristics of less dosage, rapid absorption and high bioavailability, expands the application field of the Chinese medicinal material dendrobium officinale, accelerates upgrading and updating of dendrobium officinale products, opens up a market consumption channel, increasessale channels and enriches the functional food industry structure.

Description

technical field [0001] The invention belongs to the technical field of application of traditional Chinese medicinal materials, and in particular relates to a dendrobium candidum oil dripping pill and a preparation method thereof. Background technique [0002] Dendrobium officinale (Dendrobium officinale) is a perennial herb of the genus Dendrobium orchidaceae, and is a precious and rare Chinese medicinal material. In the Taoist medical classic "Tao Zang" more than a thousand years ago, Dendrobium candidum was listed as the first of the nine Chinese immortal grasses. It is known as "the gold in medicine", and the folks call it "life-saving immortal grass". Dendrobium candidum has been highly praised by doctors of all ages for its effect of nourishing the stomach and promoting body fluid. It is recorded in "Shen Nong's Materia Medica" and "Materia Medica Zaixin" that it is "mainly nourishing life to respond to the sky, non-toxic", can be "multiple and long-term consumption" w...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/20
Inventor 麦丽谊蒋杰安金蒙罗芮李沙
Owner 东莞暨南大学研究院
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