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Preparation method and application of novel medicine-carrying bowl-shaped particle

A particle and bowl-shaped technology, which is applied in the field of preparation of drug-loaded bowl-shaped particles, can solve the problems of easy decomposition and poor stability, and achieve the effects of increasing curative effect, high yield and short preparation cycle

Inactive Publication Date: 2018-01-19
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Curcumin (CUR) is an active substance extracted from the rhizomes of turmeric, turmeric and other plants in the ginger family. It is relatively safe for humans, but it is easy to decompose in a neutral and alkaline environment and has poor stability. Due to these defects, it has not been widely used in clinical practice

Method used

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  • Preparation method and application of novel medicine-carrying bowl-shaped particle
  • Preparation method and application of novel medicine-carrying bowl-shaped particle
  • Preparation method and application of novel medicine-carrying bowl-shaped particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Weigh 87.5 mg of PLGA, 12.5 mg of PF127 and 6 mg of CUR and dissolve them together in 2 mL of dichloromethane to make an organic solution;

[0043] (2) Add 150 μL of 3% ammonium bicarbonate aqueous solution dropwise to the organic solution to obtain an organic mixed solution containing ammonium bicarbonate;

[0044] (3) Add the above organic mixed solution dropwise into 4 mL of 5% polyvinyl alcohol aqueous solution to form emulsion I;

[0045] (4) Pour the above emulsion I into 50 mL of 0.05% polyvinyl alcohol aqueous solution quickly to form emulsion II;

[0046] (5) At room temperature, volatilize the organic solvent in the above emulsion II;

[0047] (6) Collect the above-mentioned particles by centrifugation and wash them three times with deionized water at a centrifugation rate of 6000 rpm for 20 min;

[0048] (7) Redisperse the above nanoparticles in 1 mL aqueous solution containing 5% trehalose;

[0049] (8) Freeze the above-mentioned nanoparticles in a -8...

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Abstract

The invention discloses a preparation method and application of novel medicine-carrying bowl-shaped particle. According to the preparation method and the application, the medicine-carrying bowl-shapedparticle is prepared by virtue of a water-in-oil-in-water emulsified solvent evaporation method and is subjected to a series of characterizations. Field emission scanning electron microscopy finds that the particle size of the prepared bowl-shaped particle is 1.86+ / -0.20 microns, and the bowl-shaped particle has relatively narrow size distribution and relatively high medicine-carrying capacity (4.48+ / -0.12%). After the medicine-carrying bowl-shaped particle is orally taken by a mouse with ulcerative colitis, a result shows that the bowl-shaped particle has a good treatment effect on ulcerative colitis, and furthermore, the bowl-shaped particle has very good medical application prospects.

Description

technical field [0001] The invention belongs to the technical field of micron drug carriers, and in particular relates to a preparation method, characterization and application of drug-loaded bowl-shaped particles. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a type of inflammatory bowel disease, which often occurs in the transverse colon and descending colon of the colon. Patients usually present with clinical symptoms such as diarrhea, blood in the stool, weight loss, abdominal pain, fatigue, and fever. According to data, the incidence of ulcerative colitis is relatively high in European and American countries. Taking the United States as an example, the incidence is as high as 2‰, and the recurrence rate is particularly high. Traditional therapeutic drugs mainly include aminosalicylic acid drugs, immunosuppressant drugs and glucocorticoid drugs. [0003] In recent years, micro- and nano-particles based on polylactic-co-glycolic acid (PLGA...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/12A61K47/34A61P1/04A61P1/00
Inventor 肖波陈秋波
Owner SOUTHWEST UNIVERSITY
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