Method for preparing three-layer sharp type composite membrane for improving fracture healing

Abstract

The invention provides a method for making a three-layer pointed composite membrane for improving fracture healing, which includes the following steps: 1) making a model with a "V"-shaped top corner section in advance and matching the fracture line section; 2) making wet The elastic layer, the drug layer, and the guide layer, the elastic layer is a dense degradable or non-degradable biofilm, the drug layer is encapsulated with a drug slow-release system that can promote bone healing, and the material is made of human bone bio A well-compatible degradable or absorbable material, the material of the guide layer is a degradable or non-degradable, absorbable or non-absorbable porous material that is biocompatible with human bone; 3) Cover the wet elastic layer on the model On the top corner, wrap the top corner of the model and extend to both sides of the top corner of the model, then cover the wet drug layer on the elastic layer, and then cover the wet guide layer on the drug layer; 4) Wait for the three-layer composite film to air dry After the shape is fixed, the prepared three-layer composite film is peeled off from the top corner of the model.

Description

technical field [0001] The invention relates to a manufacturing method of a three-layer pointed composite membrane for improving fracture healing. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anast...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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