Vaginal film provided with micron-sized holes

A vaginal plug, micron-scale technology, applied in the field of vaginal plug membrane preparation, can solve the problems of hard texture, poor moisturizing property, low bioabsorbability and the like of vaginal membrane preparation, and achieve the effect of relieving inflammation symptoms

Inactive Publication Date: 2018-02-09
香港和和有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One purpose of the present invention is to propose a novel vaginal plug film, which can solve the use problems derived from the characteristics of hard texture, poor moisture retention, and low bioabsorbability of currently commercially available vaginal films.

Method used

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  • Vaginal film provided with micron-sized holes
  • Vaginal film provided with micron-sized holes
  • Vaginal film provided with micron-sized holes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] "Example 1: Preparation of Cortex Phellodendron Extract-Carboxymethyl Cellulose"

[0030] The preparation of Phellodendron bark extract-carboxymethyl cellulose is improved from the method described in the literature Med Princ Pract.2006; 15(5):373-8, and the bark extract of Phellodendron barkberry containing high concentration of berberine is referred to the same literature obtained. After drying the residue and grinding the residue into powder, immerse the powder in 5% sodium hydroxide solution for about 2 hours at room temperature, then immerse the powder in 10% sodium hydroxide solution and heat to 90°C. Keep warm for about 4 hours. Afterwards, the obtained substrate is decolorized with a solution of sodium hypochlorite (NaClO) and hydrogen peroxide at a weight ratio of 3:4, and then the decolorized substrate is washed with water. Next, dry the matrix with a suction filter for about 2 hours. After alkalizing the substrate at 30°C for about 60 minutes, the substrat...

Embodiment 2

[0031] "Example 2: Preparation of thin film"

[0032] Use a magnetic stirrer to uniformly mix the aforementioned Phellodendron amurense extract-carboxymethyl cellulose powder, sodium hyaluronate, polyvinyl alcohol, Tween-80, and such as sapindus seed oil, olive oil, almond oil, Or avocado oil and other vegetable oils or water to form a mixture of micron-sized oil droplet particles or water droplet particles that contain vegetable oil or water and pass through Tween-80. In addition, if necessary, the above substances can also be mixed with guanidine disinfectant ingredients such as chlorhexidine acetate, chlorhexidine gluconate, or polyhexamethylene biguanide during mixing to form a vegetable oil or water-permeable A mixture of micron-sized oil droplet particles or water droplet particles formed by passing through Tween-80. Take 3mL of the mixture into a circular mold (diameter: about 60mm, depth: about 15mm). Finally, put the mold in an oven at 37°C for about 3 hours to form...

Embodiment 3

[0033] "Example 3: Detection of Berberine"

[0034] The concentration of berberine was measured in a NanoDrop UV-Vis spectrophotometer with light at a wavelength of 260nm. For details, please refer to Photochem Photobiol Sci.2009Jul;8(7):970-4. The calibration curve of the berberine standard was obtained by selecting six concentration points with R values ​​greater than 0.99 from 37.25 to 1000 μg / mL. Before measurement, the film was dissolved in double distilled water so that the resulting solution had a concentration of 500 μg / mL. The berberine content released from the test films was calculated from the calibration curve.

[0035] like Figure 1A As shown, the ultraviolet-visible light spectrum of the standard product has two strong peaks at about 250nm and 350nm, and one weak peak at about 430nm. In addition, the spectral pattern of Phellodendron bark extract is similar to that of the standard product, and there are also two strong peaks at about the same position, while ...

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Abstract

The invention provides a thin film and an application to preparation of a vaginal film. The thin film is provided with a plurality of holes with diameter ranging from 5 mu m to 100 mu m and further contains CMC (carboxymethyl cellulose) and HA (hyaluronic acid). The vaginal film can be endowed with good water-retaining property by means of the water-retaining property of the thin film, so that thevagina is kept wet when the vaginal film is placed in the vagina. Besides, the vaginal film can be rolled into a ball by means of high ductility and flexibility of the thin film, so that the externalgenital part or the vagina is not susceptible to damage when the vaginal film is placed into the vagina. The surface area of the thin film can be increased by the holes, and accordingly, contact withfluid can be increased when the vaginal film is placed into the vagina, and absorption and action of effective components can be increased. Further, the vaginal film can be auto-absorbed when placedin the vagina by means of the high bio-absorbability of the thin film. Inflammation symptoms can be relieved when the vaginal film is placed in the vagina by means of the anti-inflammation characteristic of the thin film.

Description

technical field [0001] The present invention relates to a medical material application of a film containing carboxymethyl cellulose (Carboxy Methyl Cellulose, CMC) and hyaluronic acid (Hyaluronic Acid, HA), and in particular to a use of the film for preparing a vaginal plug . Background technique [0002] Traditionally, when women use vaginal film, they must first knead the film into a ball, and then insert the film into the vagina. Through the active ingredients in the vaginal film, relieve discomfort such as dryness, itching, redness, pain, or burning caused by vaginal inflammation. The currently commercially available vaginal film can refer to the "Baofukang vaginal film" described in the Chinese Mainland Invention Patent Publication No. CN1650961, which is made of raw materials and auxiliary materials, and the raw materials use curcuma oil and borneol as active ingredients , and add film-forming materials, antioxidants, humectants, and plasticizers and other auxiliary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/36A61K47/32A61K47/44A61K31/4375A61K36/756A61K31/045A61K36/489A61K36/9066A61P15/02A61P31/04A61P31/10A61P33/02
CPCA61K9/0034A61K9/7007A61K31/045A61K31/4375A61K36/489A61K36/756A61K36/9066A61K47/32A61K47/36A61K47/38A61K47/44
Inventor 黄俞智叶孟莹黄琨裕黄豪铭徐和
Owner 香港和和有限公司
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