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Powder scraping device for capsule filling machine

A filling machine and capsule technology, applied in the directions of capsule delivery, drug delivery, pharmaceutical formulation, etc., can solve the problems of too large difference in the filling volume of capsules, inability to achieve uniform powder scraping, and small surface area of ​​the powder scraper, and reduce the The risk of delamination, the force of scraping powder is large, and the effect of improving the effect of large difference in filling volume

Pending Publication Date: 2018-02-16
上海合全医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a powder scraping device for a capsule filling machine, which solves the problem that the powder scraper equipped with the filling unit of the existing capsule filling equipment has a small surface area, a poor position, and cannot achieve uniform scraping. The role of powder, and the problem of excessive capsule filling volume that often occurs during the capsule powder filling process

Method used

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  • Powder scraping device for capsule filling machine
  • Powder scraping device for capsule filling machine
  • Powder scraping device for capsule filling machine

Examples

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Embodiment

[0035] like figure 1As shown, in the powder filling process of an immediate-release capsule, due to the poor fluidity of the mixed powder, the metering plate is slightly thicker than 1.5mm, and the difference in the filling volume cannot be controlled during filling, and the weight of the capsule content varies greatly. The powder scraping device of the present invention is installed on the Bosch GKF 705 capsule filling machine: on the position of No. 1 station 1 of the corresponding metering disc, an "F" shaped Teflon powder scraper is installed on the metal plate 10 (that is, the first Scraper A), there is a screw hole 6 on the metal plate 10 corresponding to the No. 1 station 1 of the metering disc, and the "F" vertical line of the first scraper A is provided with a screw thread, which matches the screw hole 6 Tighten it, and install the first scraper A on the metal plate 10 corresponding to the No. 1 station 1 of the metering disc. like image 3 As shown in (A), the thic...

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Abstract

The invention discloses a powder scraping device for a capsule filling machine. The powder scraping device comprises a first scraping sheet and a second scraping sheet, the first scraping sheet and the second scraping sheet are located between a metering panel and a metal plate of the capsule filling machine, the metal plate is located above the metering panel, and the first scraping sheet and thesecond scraping sheet are fixed onto the metal plate; the position of the first scraping sheet corresponds to a first station on the upper right portion of the metering panel; the position of the second scraping sheet corresponds to the portion between a third station on the upper left portion of the metering panel and a fourth station on the lower left portion of the metering panel. The powder scraping device is particularly suitable for powder capsule filling with excessively thick metering panels, and the problem of large difference of filling quantity can be solved; after capsules are filled with powder, the powder cannot be in a column shape, or the column-shape density is low, and disintegration and releasing of the capsules cannot be delayed; for low-dose filling, a powder bed canbe well scraped to be flat and evenly dispersed into filling holes of the metering panel so that stable filling quantity can be maintained; the powder scraping device is large in superficial area andlarge in powder scraping intensity, and can reduce the layering risk of the powder in the powder bed and the over-lubricating risk after magnesium stearate is added.

Description

technical field [0001] The invention relates to capsule filling equipment in the field of oral solid preparations, in particular to direct filling of capsule powder in the field of oral solid preparations, and in particular to a powder scraping device for a capsule filling machine. Background technique [0002] In the current pharmaceutical field, more and more small-molecule compounds are synthesized, screened, and modified in order to develop active molecules with high affinity and efficacy for the target, which has become the most important problem that new drug development scientists need to solve . In order to make these small molecular compounds permeate the biological semipermeable membrane of the human body better, and at the same time have acceptable water solubility, the functional groups in the molecules are continuously optimized, and the particle size of the physical form is also micronized to several Tens of microns or even hundreds of nanometers, which leads ...

Claims

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Application Information

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IPC IPC(8): A61J3/07
CPCA61J3/074
Inventor 江陶钟云路刘春晖赵建郭晓静杨雪
Owner 上海合全医药有限公司