Preparation method of anti-asthmatic antitussive capsules

A capsule and anti-asthmatic technology, applied in the field of preparation of Pingchuan Zhike capsules, can solve the problems of reducing the utilization rate of medicinal materials, large dosage, waste and the like, shortening the disintegration time and the onset time, improving the preparation process, and improving the effect the effect of strength

Inactive Publication Date: 2018-02-16
JIANGSU 707 NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not only alcohol-soluble ingredients in the medicinal materials (Yemachai, Tianxianzi, and cicada slough), but the active ingredients are not completely extracted by alcohol extraction alone, which reduces the utilization rate of the medicinal materials and causes waste.
In addition, Anchuan tablets are hard in texture, take a long time to disintegrate, and take a large amount (4 tablets at a time, 3 times a day)

Method used

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  • Preparation method of anti-asthmatic antitussive capsules
  • Preparation method of anti-asthmatic antitussive capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of anti-cough capsules mainly includes the following steps:

[0027] (1) The wild horse chase, hydrangea, and cicada were extracted three times with 80% ethanol under reflux, and the volume of ethanol used was 5, 4, and 4 times the weight of the medicinal material respectively; the extraction time was 2h, 1h, 1h, and the medicinal solution was combined , Filter, and recover ethanol from the filtrate until the alcohol content of the medicinal solution is 30%-40%, to obtain a mixture of medicinal material alcohol extracts for use;

[0028] (2) Add water to decoct the residues of Yemachai, Tianxianzi and Cicada slough medicinal materials twice, add water volume to 5 times and 4 times the weight of medicinal materials, 2h each time, the medicinal solution is filtered and concentrated, settled for 24h, and the supernatant is filtered out , Concentrated to a Baume degree of 6°Be (60°C), combined with the alcohol extract mixture, and concentrated into an extrac...

Embodiment 2

[0033] A preparation method of anti-cough capsules mainly includes the following steps:

[0034] (1) The wild horse chase, hydrangea, and cicada were extracted three times with 80% ethanol under reflux, and the volume of ethanol used was 7 times, 6 times, and 6 times the weight of the medicinal materials; the extraction time was 3h, 2h, 1h, and the medicinal solution was combined , Filter, and recover ethanol from the filtrate until the alcohol content of the medicinal solution is 30%-40%, to obtain a mixture of medicinal material alcohol extracts for use;

[0035] (2) Add water to decoct the residues of Yemazhu, Tianxianzi and Cicada slough medicinal materials twice, add water volume to 6 times and 5 times the weight of medicinal materials, 2 hours each time, the medicinal solution is filtered and concentrated, settled for 24 hours, and the supernatant is filtered out , Concentrated to Baume degree 8°Be (70°C), combined with the alcohol extract mixture, and concentrated into extra...

Embodiment 3

[0040] A preparation method of anti-cough capsules mainly includes the following steps:

[0041] (1) The wild horse chase, hydrangea, and cicada were extracted three times with 80% ethanol under reflux, and the volume of ethanol used was 10 times, 8 times, and 8 times the weight of the medicinal materials; the extraction time was 3h, 1h, 2h, and the medicinal solution was combined , Filter, and recover ethanol from the filtrate until the alcohol content of the medicinal solution is 30%-40%, to obtain a mixture of medicinal material alcohol extracts for use;

[0042] (2) Add water to decoct the residues of Yemachai, Tianxianzi, and Cicada slough medicinal materials twice, add water volume to 8 times and 6 times the weight of medicinal materials, 2 hours each time, the medicinal solution is filtered and concentrated, precipitated for 24 hours, and the supernatant is filtered out , Concentrated to a Baume degree of 10°Be (80°C), combined with the alcohol extract mixture, and concentra...

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Abstract

The invention discloses a preparation method of anti-asthmatic antitussive capsules. The method comprises the following steps: extraction of medicinal materials, drying, granulation, breaking, total blending, filling of capsules, packaging and the like. In the extraction of medicinal materials, lindley eupatorium herb, semen hyoscyami and periostracum cicada are firstly extracted with ethanol, andthen water is added to decoct and extract residual medicinal materials obtained after the extraction. Through the extraction step, water-soluble components and alcohol soluble components in main components of the medicinal materials are completely extracted. Thus, the purpose of fully utilizing raw medicinal materials is achieved, utilization rate of medicinal materials is raised, and efficiencyis enhanced. The prepared anti-asthmatic antitussive capsules have advantages of stable quality, high bioavailability, accurate drug content and obvious curative effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a method for preparing an antiasthmatic and antitussive capsule. Background technique [0002] Anchuan Tablet is a tablet made of Yema Zhui, Tianxianzi, Cicada slough, Vitex oil, Clenbuterol hydrochloride, and Chlorpheniramine maleate. It has the effects of relieving cough and expectorant, promoting lung and relieving asthma. Used for turbid phlegm, lung failure, chest tightness, coughing, wheezing, excessive phlegm, acute and chronic bronchitis, see the above symptoms. [0003] Yemachai is the whole plant of Lin Zelan, a plant belonging to the genus Eupatorium of the Compositae family. It has a bitter nature and a calming taste, and it returns to the liver and spleen meridian. It is often used clinically to treat chronic bronchitis, bronchitis, and hypertension. Its branches and leaves are used as medicine to dehumidify and neutralize dampness. It is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/48A61P11/06A61P11/14A61P11/10A61P9/12A61K36/28A61K35/64A61K36/85A61K31/137A61K31/4402
CPCA61K9/4858A61K31/137A61K31/4402A61K35/63A61K36/28A61K36/81A61K36/85A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 袁佳吴刚黄艳
Owner JIANGSU 707 NATURAL PHARMA
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