Gelatin small peptide or collagen tripeptide chelated calcium magnesium and preparation method thereof

A technology of collagen tripeptide and chelated calcium, which is applied in the functions of food ingredients, food science, applications, etc., can solve the problems of reducing the utilization rate of calcium, achieve small molecular weight of raw materials, improve chelation efficiency and bioavailability, and improve The effect of calcium supplementation effect

Inactive Publication Date: 2018-02-23
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as we all know, collagen has a large molecular weight and cannot be directly absorbed and utilized by the human body, or is directly excreted, or is hydrolyzed into small gelatin peptides of different lengths in gastric juice, so that the calcium ions that were originally chelated will be absorbed by the collagen Protein degradation destroys the chelate structure and releases inorganic calcium ions, reducing the utilization of calcium

Method used

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  • Gelatin small peptide or collagen tripeptide chelated calcium magnesium and preparation method thereof
  • Gelatin small peptide or collagen tripeptide chelated calcium magnesium and preparation method thereof
  • Gelatin small peptide or collagen tripeptide chelated calcium magnesium and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Using gelatin as the ionophore raw material, calcium chloride and magnesium chloride are prepared into calcium magnesium salt mixture according to the molar ratio of calcium and magnesium ions of 1:0.2, gelatin and calcium magnesium salt mixture are mixed according to the ratio of 1:1 by weight, according to water and The weight ratio of the calcium-magnesium salt mixture is 1:0.5, add water and stir well to obtain a mixed solution; adjust the pH to 4 with citric acid and stir well, the resulting mixed solution undergoes swelling and ion chelation reaction at 80°C, and the reaction time is 20 Minutes, the resulting product was diluted with an appropriate amount of pure water, dialyzed with a nanofiltration membrane with a molecular weight cut-off of 150Da and concentrated to 0.8 times the volume before dilution; the concentrated solution was collected and vacuum freeze-dried.

Embodiment 2

[0039] Using gelatin as the ionophore raw material, calcium chloride and magnesium chloride are formulated into a calcium-magnesium salt mixture according to the molar ratio of calcium-magnesium ions of 1:0.5, and the gelatin and calcium-magnesium salt mixture are mixed according to a weight ratio of 1:1. The weight ratio of the calcium-magnesium salt mixture is 1:0.5, add water and stir well to obtain a mixed solution; adjust the pH to 4 with citric acid and stir well, the resulting mixed solution undergoes swelling and ion chelation reaction at 80°C, and the reaction time is 20 Minutes, the resulting product was diluted with an appropriate amount of pure water, dialyzed with a nanofiltration membrane with a molecular weight cut-off of 150Da and concentrated to 0.8 times the volume before dilution; the concentrated solution was collected and vacuum freeze-dried.

Embodiment 3

[0041] Using gelatin as the ionophore raw material, calcium chloride and magnesium chloride are prepared into calcium magnesium salt mixture according to the ratio of calcium and magnesium ion molar ratio of 1:0.3, gelatin and calcium magnesium salt mixture are mixed according to the ratio of weight ratio of 1:1, according to water and The weight ratio of the calcium-magnesium salt mixture is 1:0.5, add water and stir well to obtain a mixed solution; adjust the pH to 4 with citric acid and stir well, the resulting mixed solution undergoes swelling and ion chelation reaction at 80°C, and the reaction time is 20 Minutes, the resulting product was diluted with an appropriate amount of pure water, dialyzed with a nanofiltration membrane with a molecular weight cut-off of 150Da and concentrated to 0.8 times the volume before dilution; the concentrated solution was collected and vacuum freeze-dried.

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Abstract

The invention relates to a gelatin small peptide or collagen tripeptide chelated calcium magnesium and a preparation method thereof. The preparation method comprises the following steps: 1, preparinga calcium and magnesium salt mixture from a soluble calcium salt and a soluble magnesium salt according to a molar ratio of calcium ions to magnesium ions is 1:(0.2-0.5), adding gelatin or collagen tripeptide as an ion carrier raw material, adding water according to a weight ratio of the water to the calcium and magnesium salt mixture of 1:(0.5-2), and carrying out full and uniform stirring to obtain a mixed solution; 2, adjusting the pH value of the mixed solution to 4-5.5 by using an organic acid; 3, carrying out an ion chelating reaction at 80-200 DEG C; and 4, adding water to dilute the obtained reaction solution, carrying out dialysis concentration by using a nanofiltration membrane with the molecular weight cutoff being 150-300 Da to make the volume of the obtained concentrate is 1.2-0.8 times the volume of the undiluted solution in order to obtain the gelatin small peptide or collagen tripeptide chelated calcium magnesium. The gelatin small peptide or collagen tripeptide chelated calcium magnesium preparation prepared in the invention does not release inorganic ions with the hydrolysis of macromolecular collagens after entering a body in order to guarantee that the calcium and magnesium absorbed and utilized in small peptide chelate organic forms, so the absorption efficiency and the bioavailability of the calcium and magnesium are improved.

Description

technical field [0001] The invention relates to a calcium supplement health product and a preparation method thereof, in particular to a gelatin small peptide or collagen tripeptide chelated calcium and magnesium and a preparation method thereof. Background technique [0002] Calcium, as an extremely important constant element, is distributed throughout the body. Among them, 99% of calcium exists in bones and teeth, and the other 1% of calcium exists in soft tissue, extracellular fluid and blood. Animal life activities such as transmission of nerve substances, heartbeat, muscle contraction, etc. are all using and consuming calcium. Therefore, calcium plays an important role in the material metabolism of the body and the maintenance of life. [0003] Magnesium is an essential mineral element for the human body, accounting for about 0.05% of body weight. Nearly 70% of magnesium in the human body exists in bones and teeth in the form of magnesium phosphate and magnesium carbo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/165
CPCA23L33/165A23V2002/00A23V2200/30A23V2200/306A23V2250/1578A23V2250/161
Inventor 杨水云赵浩淼赵良瑞吴丹徐文李少峰
Owner XI AN JIAOTONG UNIV
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