T2 contrast agent and its preparation method and use

A technology of contrast agent and complexing agent, applied in the field of nanomaterials, can solve the problems of weakened contrast effect, unsuitable observation of the fine structure of the lesion, limited production and application, etc.

Active Publication Date: 2021-01-01
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among the many materials with contrast effect, gadolinium (Gd), because of its 7 unpaired electrons, its chelate and inorganic nanomaterials are clinically widely used T1-weighted MRI contrast agents, but gadolinium-based contrast agents The T1 contrast effect of the agent under high field weakens with the increase of the magnetic field, which is not suitable for observing the fine structure of the lesion under high field, and has not found a simple and effective synthesis and water-soluble method of gadolinium-based nanomaterials. The method of sexual modification limits its production and application
[0003] Therefore, the contrast agent suitable for observing the lesion under high field needs to be further studied

Method used

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  • T2 contrast agent and its preparation method and use
  • T2 contrast agent and its preparation method and use
  • T2 contrast agent and its preparation method and use

Examples

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Effect test

Embodiment 1

[0058] In this example, the inventor prepared a T2 contrast agent with a particle size of 120nm, and the specific operation steps are as follows:

[0059] At room temperature, measure 0.2mol / L of Gd(ClO 4 ) 3 Add 5mL of aqueous solution to 5mL of 0.6mol / L trisodium citrate aqueous solution, stir and mix, the reaction solution appears white precipitate and becomes clear quickly, inject 15mL of 0.5mol / L NaF solution under rapid stirring, the reaction solution immediately Produce white turbidity, in this reaction system, Gd(ClO 4 ) 3 The concentration of the solution is 0.04mol / L, and the concentration of the NaF solution is 0.3mol / L. After the reaction, the product obtained is centrifuged at 6000r / min for 10min, and the product obtained is washed once with ethanol and deionized water. The resulting white precipitate of NaGdF 4 Disperse in 10mL ethanol to obtain NaGdF4 suspension. Take 3mL of NaGdF4 suspension, add ethanol to 15mL, add 90μL 28wt% ammonia water, inject 90μL T...

Embodiment 2

[0061] In this example, the inventor prepared a T2 contrast agent with a particle size of 190nm, and the specific operation steps are as follows:

[0062]At room temperature, measure 0.2mol / L of Gd(ClO 4 ) 3 Add 5mL of aqueous solution to 5mL of 0.3mol / L trisodium citrate aqueous solution, stir and mix, the reaction solution appears white precipitate and becomes clear quickly, inject 15mL of 0.5mol / L NaF solution under rapid stirring, the reaction solution immediately Produce white turbidity, in this reaction system, Gd(ClO 4 ) 3 The concentration of the solution is 0.04mol / L, and the concentration of the NaF solution is 0.3mol / L. After the reaction, the product obtained is centrifuged at 6000r / min for 10min, and the product obtained is washed once with ethanol and deionized water. The resulting white precipitate of NaGdF 4 Disperse in 10mL ethanol to obtain NaGdF4 suspension. Take 3mL of NaGdF4 suspension, add ethanol to 15mL, add 80μL 28wt% ammonia water, inject 80μL TE...

Embodiment 3

[0064] In this example, the inventor prepared a T2 contrast agent with a particle size of 250nm, and the specific operation steps are as follows:

[0065] At room temperature, measure 0.2mol / L of Gd(ClO 4 ) 3 Add 5mL of aqueous solution to 5mL of 0.2mol / L trisodium citrate aqueous solution, stir and mix, the reaction solution appears white precipitate and becomes clear quickly, inject 15mL of 0.5mol / L NaF solution under rapid stirring, the reaction solution immediately Produce white turbidity, in this reaction system, Gd(ClO 4 ) 3 The concentration of the solution is 0.04mol / L, and the concentration of the NaF solution is 0.3mol / L. After the reaction, the product obtained is centrifuged at 6000r / min for 10min, and the product obtained is washed once with ethanol and deionized water. The resulting white precipitate of NaGdF 4 Disperse in 10mL ethanol to obtain NaGdF4 suspension. Take 3mL of NaGdF4 suspension, add ethanol to 15mL, add 70μL 28wt% ammonia water, inject 70μL T...

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Abstract

The invention discloses a T2 contrast agent and a preparation method and applications thereof. The T2 contrast agent comprises a gadolinium based nano material and a silica layer. The silica layer covers at least part of the external surface of the gadolinium based nano material. The T2 contrast agent has a good water soluble property and biocompatibility. The T2 contrast agent is especially suitable for observing the fine structure of lesion under a high magnetic field and the contrast effect is excellent.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a water-soluble gadolinium-based nanomaterial T2 contrast agent and its preparation method and application. Background technique [0002] Magnetic resonance imaging has become a powerful tool for disease diagnosis due to its radiation-free and non-invasive nature to the human body, as well as its ultra-high spatial resolution. In magnetic resonance imaging, in order to improve the contrast imaging effect of the lesion, it is often necessary to use a contrast agent. The introduction of the contrast agent can shorten the T1 and T2 relaxation time of the lesion, thereby improving its contrast with the surrounding tissue. The commonly used contrast agent Agents include paramagnetic gadolinium-based small molecules and nanomaterials and ferromagnetic nanomaterials. Among the many materials with contrast effect, gadolinium (Gd), because of its 7 unpaired electrons, its chelate and inorgan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/08A61K47/02A61K47/04
CPCA61K47/02A61K49/08
Inventor 王春儒卢志高甄明明
Owner INST OF CHEM CHINESE ACAD OF SCI
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