Oesophagogastric junction adenocarcinoma related biomarker and application thereof

A technology for gastric junction adenocarcinoma and esophagogastric cancer, applied in the field of NFIB, can solve the problems of unreported function

Active Publication Date: 2018-03-30
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Description
  • Claims
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Problems solved by technology

[0005] At present, the function of NFIB in esophagogastric junction adenocarcinoma has not been reported. Exploring the biological function of NFIB in e

Method used

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  • Oesophagogastric junction adenocarcinoma related biomarker and application thereof
  • Oesophagogastric junction adenocarcinoma related biomarker and application thereof
  • Oesophagogastric junction adenocarcinoma related biomarker and application thereof

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[0037] specific implementation

[0038] The present invention studies the clinicopathological data of patients with esophagogastric junction adenocarcinoma who have received surgical treatment, and uses immunohistochemistry (IHC) in the immunoassay method to detect the expression of NFI transcription factor in cancer tissues and paracancerous tissues The relationship between the expression of NFI transcription factors and clinical case factors such as clinical stage, degree of tumor differentiation and lymph node metastasis in patients with esophagogastric junction adenocarcinoma was analyzed, and the Cox proportional hazard regression model was constructed to further analyze the role of NFI transcription factors in predicting esophagogastric junction adenocarcinoma. The prognostic significance of junctional adenocarcinoma provides an important theoretical basis for the diagnosis and prognosis of esophagogastric junction adenocarcinoma.

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Abstract

The invention discloses an oesophagogastric junction adenocarcinoma related biomarker and application thereof. The biomarker is NFIB. The invention discloses application of NFIB in diagnosis of oesophagogastric junction adenocarcinoma, and application of NFIB in predicting lymph node metastasis, TNM staging, and prognosis of the oesophagogastric junction adenocarcinoma; the invention further provides a kit for diagnosis of the oesophagogastric junction adenocarcinoma, and a kit for predicting the lymph node metastasis, the TNM staging, and the prognosis of the oesophagogastric junction adenocarcinoma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a biomarker related to esophagogastric junction adenocarcinoma and application thereof, specifically the biomarker is NFIB. Background technique [0002] Esophagogastric junction adenocarcinoma is a special type of malignant tumor, and its incidence is gradually increasing. It has become one of the fastest growing malignant tumors in western developed countries. Therefore, the research on esophagogastric junction adenocarcinoma has been paid more and more attention worldwide. Since more than 80% of patients with esophagogastric junction adenocarcinoma are in the middle and advanced stages, the 5-year survival rate of the middle and late stage patients is low, and the prognosis is extremely poor. In previous studies, esophagogastric junction cancer was classified as esophageal adenocarcinoma or gastric cancer, but recently it was found that it has unique molecular features, case evolutio...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886C12Q2600/118C12Q2600/158G01N33/57407
Inventor 周智航李立韬袁小东李立宋锦文余琦
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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