miRNA marker associated with colorectal cancer metastasis in plasma and application thereof

A technology of colorectal cancer and markers, applied in the fields of biotechnology and medicine, can solve the problems of insufficient typical indications, difficulty in becoming a patient with colorectal cancer liver metastases, and high complications, so as to reduce pain, make it easier to obtain, and improve accuracy sexual effect

Active Publication Date: 2018-04-06
广西壮族自治区肿瘤防治研究所
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Problems solved by technology

[0006] Traditional screening methods such as laparoscopy, fine-needle aspiration cytology and imaging methods such as enhanced computed tomography (CT), magnetic resonance imaging (MRI) are invasive, high in complications or insufficient in typical indications, Therefore, it is difficult to become an effective method for early screening of patients with colorectal cancer liver metastases

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  • miRNA marker associated with colorectal cancer metastasis in plasma and application thereof
  • miRNA marker associated with colorectal cancer metastasis in plasma and application thereof
  • miRNA marker associated with colorectal cancer metastasis in plasma and application thereof

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Embodiment Construction

[0024] The present invention will be further described in detail below with reference to the accompanying drawings, so that those skilled in the art can implement it with reference to the text of the description.

[0025] It should be noted that the experimental methods described in the following embodiments are conventional methods unless otherwise specified, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0026] Part 1: Bioinformatics analysis and screening of miRNAs related to colorectal cancer metastasis

[0027] Materials and Methods

[0028] 1. Technical methods and data analysis process (see figure 1 )

[0029] 2. Acquisition of miRNA and gene expression data

[0030] The search keywords in the GEO database in this study were "Colorectal cancer", "Colon cancer", "rectal cancer", "Colonic carcinoma", "Metastasis", "Hepatic metastasis", "livermetastasis", "MicroRNAs". It also searched Google Scholar and Baidu Academic, and sear...

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Abstract

The invention discloses a miRNA marker associated with colorectal cancer metastasis in plasma and an application thereof and belongs to the technical fields of biotechnologies and medicine. The miRNAmarker associated with colorectal cancer metastasis in plasma is one or more of miR-96, miR-99b, miR-155, let-7a and let-7b. The specificity and sensitivity of the miRNA marker associated with colorectal cancer metastasis in plasma screened in the invention for predicting the colorectal cancer metastasis are obviously higher than those of a clinically used tumor marker CEA at present, and the diagnostic accuracy is greatly improved.

Description

Technical field [0001] The present invention relates to the fields of biotechnology and medical technology. More specifically, the present invention relates to miRNA markers associated with colorectal cancer metastasis in plasma and their applications. Background technique [0002] Colorectal cancer (CRC) is one of the common digestive tract cancers and the third leading cause of cancer-related deaths worldwide. The occurrence of colorectal cancer liver metastasis is a multi-factor and multi-step process. About 20-25% of CRC patients are initially diagnosed with liver metastases, and up to 40-50% of patients develop liver metastases after resection of the primary tumor. Most patients with colorectal and liver metastases are not suitable for radical surgical resection, and the five-year survival rate is ≤10%. [0003] The occurrence of liver metastasis in patients with colorectal cancer is not only related to abnormal or loss of proto-oncogene and tumor suppressor gene expression...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 张力图宁淑芳刘海洲陈伊利基林韦文娥谭晓玉唐亚梅
Owner 广西壮族自治区肿瘤防治研究所
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