Application of ibc2 compound in preparation of drugs for preventing and treating bladder cancer
A bladder cancer and drug technology, which is applied in the application field of iBC2 in the preparation of drugs for the prevention and treatment of bladder cancer, can solve problems such as the lack of effective drugs for prevention and treatment of bladder cancer, and achieve the effects of inhibiting proliferation and promoting apoptosis.
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[0033] Wherein, the preparation method of iBC2 compound comprises the following steps:
[0034] Step A: Cultivate Streptomyces spp. Hangzhou Bay variant to obtain fermentation broth, filter out mycelium, and obtain fermentation filtrate. The cultivation temperature of the Streptomyces is 24-33° C., the pH value of the cultivation is 5-9, and the cultivation time is 30-120 hours.
[0035] Step B: extracting the fermentation filtrate with ethyl acetate, and concentrating under reduced pressure;
[0036] Step C: put the filtrate concentrated under reduced pressure on a silica gel H wet column, and elute it through a mixture of ethyl acetate-dichloroethane (1:2), collect the eluate, and concentrate under reduced pressure to obtain a concentrated solution;
[0037] Step D: Dissolve the concentrated solution in methanol, put it on a silica gel H dry column, and elute it with a mixture of ethyl acetate-dichloroethane (1:8), collect the eluent, and concentrate the eluent under reduce...
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