A kind of production method of dimethomorph

Abstract

The invention discloses a production method of dimethomorph in the technical field of pesticide production. The production method comprises the following steps: 1) synthesis of veratrole, 2) 3,4-dimethoxy-4-chloro-diphenyl Ketone synthesis, 3) acetylmorpholine synthesis and 4) dimethomorph synthesis; synthesis of dimethomorph using sodium tert-butoxide as 3,4‑dimethoxy‑4‑chloro‑benzophenone and acetylmorpholine Basic catalyst, increase the step of using sodium hydroxide solution to carry out alkaline washing of the reactants in the reactor, and sodium hydroxide synthesizes dimethoxy morpholine from 3,4-dimethoxy-4-chloro-benzophenone and acetylmorpholine The morphine also has a catalytic effect, which makes up for the insufficiency of the gradual decrease in the catalytic effect of sodium tert-butoxide due to its unstable chemical properties when it encounters water and decomposes, and improves the conversion rate and purity of the product dimethomorph.

Description

Technical field[0001]The present invention relates to the field of pesticide production, and the specific area is a method for producing an alkenyl morpholine.Background technique[0002]Pesticide generalization refers to prevent, destroy or control diseases, insects, grass and other hazardous creatures that endanger agriculture and forestry through a purposeful regulation, control and development of hazardous organisms, growth, development and reproduction, and controlling agriculture and forestry; in daily life The narrow understanding is that it is guaranteed in agricultural production, promoting the growth of plants and crops, and a class of drugs administered, sterilized or harmful weeds are collectively referred to, and-alkenyl morpholine is an endotramal aimal low toxic sterilization The mechanism of action is to destroy the formation of the pathogenic wall film, causing the decomposition of the spore capsule to death, except for the formation of swivel spores and spores, each ...

AI Technical Summary

Problems solved by technology

[0002] In a broad sense, pesticides refer to the prevention, elimination or control of diseases, insects, weeds and other harmful organisms that endanger agriculture and forestry by purposefully regulating, controlling and affecting the metabolism, growth, development and reproduction of harmful organisms; In a narrow sense, it refers to a class of drugs used to kill insects, fungicides or harmful weeds in order to ensure and promote the growth of plants and crops in agricultural production. Dimethomorph is a systemic therapeutic low-toxic bactericidal Its mechanism of action is to destroy the formation of the cell wall membrane of the pathogen, causing the decomposition of the sporangia wall and causing the death of the pathogen. Except for the formation of zoospores and the swimming stage of the spores, it has effects on all stages of the oomycete, especially for the sporangia The formation stage of stalk and oospore is more sensitive. If the drug is used before the formation of sporangia and sporulation, the production of spores can be completely inhibited. Dimethomorph is especially effective against downy mildew and Phytophthora fungus, and can be used for grapes, potatoes and tomatoes, etc. Crop has the characteristics of less dosage, long duration and safe use, and has a good market prospect; in the existing dimethomorph production method, single sodium tert-butoxide or sodium amide is used as 3,4-dimethoxy- 4-Chloro-benzophenone and acetylmorpholine are basic catalysts for synthesizing dimethomorph. The catalytic effect is general. The chemical properties of sodium tert-butoxide and sodium amide are unstable and decompose when they meet water, resulting in a gradual decrease in catalytic effect and making the product Dimethomorph conversion and reduced purity