Dimethomorph production method

Abstract

The invention discloses a dimethomorph production method in the technical field of pesticide production. The production method comprises: 1) synthesizing veratrole; 2) synthesizing 3,4-dimethoxy-4-chloro-benzophenone; 3) synthesizing acetylmorpholine; and 4) synthesizing dimethomorph. Sodium tert-butoxide is taken as a basic catalyst for synthesizing dimethomorph from 3,4-dimethoxy-4-chloro-benzophenone and acetylmorpholine, and a sodium hydroxide solution is used to perform alkali washing on a reactant in a reaction vessel. Sodium hydroxide has a catalytic effect on synthesis of dimethomorphfrom 3,4-dimethoxy-4-chloro-benzophenone and acetylmorpholine. The defect that the catalytic effect of sodium tert-butoxide is gradually reduced due to unstable chemical property of sodium tert-butoxide and degradation of sodium tert-butoxide when sodium tert-butoxide comes into water is overcome. The dimethomorph product is improved in conversion rate and purity.

Description

technical field [0001] The invention relates to the technical field of pesticide production, in particular to a production method of dimethomorph. Background technique [0002] In a broad sense, pesticides refer to the prevention, elimination or control of diseases, insects, weeds and other harmful organisms that endanger agriculture and forestry by purposefully regulating, controlling and affecting the metabolism, growth, development and reproduction of harmful organisms; In a narrow sense, it refers to a class of drugs used to kill insects, fungicides or harmful weeds in order to ensure and promote the growth of plants and crops in agricultural production. Dimethomorph is a systemic therapeutic low-toxic bactericidal Its mechanism of action is to destroy the formation of the cell wall membrane of the pathogen, causing the decomposition of the sporangia wall and causing the death of the pathogen. Except for the formation of zoospores and the swimming stage of the spores, it...

AI Technical Summary

Problems solved by technology

[0002] In a broad sense, pesticides refer to the prevention, elimination or control of diseases, insects, weeds and other harmful organisms that endanger agriculture and forestry by purposefully regulating, controlling and affecting the metabolism, growth, development and reproduction of harmful organisms; In a narrow sense, it refers to a class of drugs used to kill insects, fungicides or harmful weeds in order to ensure and promote the growth of plants and crops in agricultural production. Dimethomorph is a systemic therapeutic low-toxic bactericidal Its mechanism of action is to destroy the formation of the cell wall membrane of the pathogen, causing the decomposition of the sporangia wall and causing the death of the pathogen. Except for the formation of zoospores and the swimming stage of the spores, it has effects on all stages of the oomycete, especially for the sporangia The formation stage of stalk and oospore is more sensitive. If the drug is used before the formation of sporangia and sporulation, the production of spores can be completely inhibited. Dimethomorph is especially effective against downy mildew and Phytophthora fungus, and can be used for grapes, potatoes and tomatoes, etc. Crop has the characteristics of less dosage, long duration and safe use, and has a good market prospect; in the existing dimethomorph production method, single sodium tert-butoxide or sodium amide is used as 3,4-dimethoxy- 4-Chloro-benzophenone and acetylmorpholine are basic catalysts for synthesizing dimethomorph. The catalytic effect is general. The chemical properties of sodium tert-butoxide and sodium amide are unstable and decompose when they meet water, resulting in a gradual decrease in catalytic effect and making the product Dimethomorph conversion and reduced purity