Drug hepatotoxicity prediction method and device

A prediction method and hepatotoxicity technology, applied in the field of drug prediction, to achieve the effect of effectively controlling the development cycle and development cost, and improving the prediction efficiency
CN108021941BInactive Publication Date: 2020-08-28SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2020-08-28
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

Embodiments of the present invention provide a drug hepatotoxicity prediction method and device, which relate to the technical field of drug prediction. The method comprises: after acquiring the data of the drug to be tested, classifying the data of the drug to be tested according to a preset classifier group to obtain a plurality of initial classification results; and then based on the plurality of initial classification results and the preset voting strategy According to the rule, a classification result is obtained, and the classification result represents the hepatotoxicity of the drug data to be tested. By classifying the drug data through the preset classifier group and voting strategy, the hepatotoxicity of the drug data can be obtained, the prediction efficiency and accuracy can be improved, and the future development needs of the pharmaceutical industry can be adapted. More effective control of development costs.
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Description

technical field

[0001] The present invention relates to the technical field of drug prediction, in particular to a drug hepatotoxicity prediction method and device. Background technique

[0002] The modern drug development process is a process of finding compounds that can interact with specific therapeutic targets and have desirable ADME / T properties. During this process, 30% of R&D failures stem from drug safety issues, and 5%-10% of drugs are canceled or even recalled due to damage to the liver during the clinical application stage. Accurate prediction of drug hepatotoxicity enables developers to discover candidate drugs that may cause hepatotoxicity in the early stages of drug development, reducing the huge R&D losses caused by drug development failures.

[0003] Traditional methods for predicting drug hepatotoxicity mainly use toxicological experimental methods based on animal experiments to predict drug hepatotoxicity. Due to the need to verify the actual application...

Claims

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