Kawasaki disease coronary artery disease risk diagnosis and detection kit

Abstract

The invention relates to the technical field of biology and particularly provides application of a Kawasaki disease-associated substance to preparation of a kit for Kawasaki disease coronary artery disease risk assessment as a biomarker. The Kawasaki disease-associated substance is selected from one or more of a Kawasaki disease-associated gene or fragments thereof, mRNA transcribed from the Kawasaki disease-associated gene or the fragments thereof and proteins encoded by the Kawasaki disease-associated gene or the fragments thereof. The Kawasaki disease-associated gene comprises one or eightof a CD247 gene, a TNFRSF1A gene, an SMAD2 gene, an MMP9 gene, a BMP2 gene, an ACVR2B gene, a CXCL14 gene and a CD14 gene. The Kawasaki disease coronary artery disease risk diagnosis and detection kitprovided by the invention can assess the Kawasaki disease coronary artery disease risk in Kawasaki disease patients and suspicious children, so that medical personnel can take appropriate treatment or preventive measures as soon as possible.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a Kawasaki disease coronary artery lesion risk diagnosis and detection kit. Background technique [0002] Kawasaki disease (KD) is a systemic vasculitis of unknown etiology in children and one of the most common causes of acquired heart disease in children. The clinical manifestations are persistent fever, rash, enlarged cervical lymph nodes, and conjunctival hyperemia , Changes in extremities and oral mucosa. [0003] If left untreated, a quarter of children will be complicated by coronary artery disease. This quarter of children can be called high-risk Kawasaki disease coronary artery children. Coronary arteritis induced by KD may lead to vascular remodeling and reconstruction, resulting in endothelial hyperplasia and vascular stenosis, with marked thickening of the inner wall of the blood vessel. And persistent coronary disease caused by KD has a high probability of cardiac com...

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Problems solved by technology

[0006] The above clinical indicators are all manifested when Kawasaki disease has developed or even caused coronary artery lesions. Therefore, it is difficult to timely diagnose Kawasaki disease and prevent coronary artery lesions based on the above indicators, and it is also difficult to find high-risk children with Kawasaki disease coronary artery lesions

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