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Gamma delta-T cell exosome used for tumor immunotherapy and preparation method of gamma delta-T cell exosome

An immunotherapy and exosome technology, which is applied in the field of tumor treatment, can solve the problems of limited efficacy and achieve the effects of avoiding diffusion difficulties, small size, and enhancing anti-tumor immunity

Active Publication Date: 2018-06-01
SICHUAN CANCER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, more studies are using DC-derived exosomes to carry tumor-specific antigens for anti-tumor therapy, but phase I clinical trials have shown very limited efficacy

Method used

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  • Gamma delta-T cell exosome used for tumor immunotherapy and preparation method of gamma delta-T cell exosome
  • Gamma delta-T cell exosome used for tumor immunotherapy and preparation method of gamma delta-T cell exosome
  • Gamma delta-T cell exosome used for tumor immunotherapy and preparation method of gamma delta-T cell exosome

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Embodiment 1

[0038] A γδT cell exosome for tumor immunotherapy, the γδT cell exosome loaded with miR-138.

[0039] The expression level of miR-138 is 500 copy / ul.

Embodiment 2

[0041] A γδT cell exosome for tumor immunotherapy, the γδT cell exosome loaded with miR-138.

[0042] The expression level of miR-138 is 1000 copy / ul.

Embodiment 3

[0044] A γδT cell exosome for tumor immunotherapy, the γδT cell exosome loaded with miR-138.

[0045] The expression level of miR-138 is 2000 copy / ul.

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Abstract

The invention provides a gamma delta-T cell exosome used for tumor immunotherapy. The gamma delta-T cell exosome is loaded with miR-138. The exosome (gamma delta TDE) derived from gamma delta-T cellscarries exogenous miR-138 for realizing direct targeted recognition and killing on tumor cells, meanwhile, PD-1 / PD-L1 is inhibited, the antitumor immunity activity of T lymphocytes / NK cells is enhanced, and the effect of inhibiting tumor growth / invasion / metastasis is achieved through direct and indirect paths.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a γδT cell exosome used for tumor immunotherapy. Background technique [0002] Tumor immunotherapy has received great attention recently, and was rated as the top ten scientific and technological breakthroughs of the year by Science in 2013, and has broad application prospects. Despite promising results in the treatment of hematological malignancies and malignant melanoma, immunotherapy has had little effect in most solid tumors. [0003] T lymphocytes are the final effector cells of anti-tumor immunity. Adoptive Cell Therapy (ACT), which reinfuses T lymphocytes activated by tumor-associated antigens (TAAs) to treat tumors, has received extensive attention in recent years. . In particular, chimeric antigen receptor (CAR)-modified T cell (CAR-T) technology has achieved rapid development and has shown strong efficacy in the treatment of hematological malignanc...

Claims

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Application Information

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IPC IPC(8): C12N5/10C12N15/867A61K31/7088A61K47/46A61K35/17A61P35/00
CPCA61K31/7088A61K35/17A61K47/46C12N5/0636C12N15/86C12N2510/00C12N2740/15043C12N2800/107A61K2300/00
Inventor 朱桂全曹邦荣
Owner SICHUAN CANCER HOSPITAL
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