Gamma delta-T cell exosome used for tumor immunotherapy and preparation method of gamma delta-T cell exosome

Abstract

The invention provides a gamma delta-T cell exosome used for tumor immunotherapy. The gamma delta-T cell exosome is loaded with miR-138. The exosome (gamma delta TDE) derived from gamma delta-T cellscarries exogenous miR-138 for realizing direct targeted recognition and killing on tumor cells, meanwhile, PD-1/PD-L1 is inhibited, the antitumor immunity activity of T lymphocytes/NK cells is enhanced, and the effect of inhibiting tumor growth/invasion/metastasis is achieved through direct and indirect paths.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a γδT cell exosome used for tumor immunotherapy. Background technique [0002] Tumor immunotherapy has received great attention recently, and was rated as the top ten scientific and technological breakthroughs of the year by Science in 2013, and has broad application prospects. Despite promising results in the treatment of hematological malignancies and malignant melanoma, immunotherapy has had little effect in most solid tumors. [0003] T lymphocytes are the final effector cells of anti-tumor immunity. Adoptive Cell Therapy (ACT), which reinfuses T lymphocytes activated by tumor-associated antigens (TAAs) to treat tumors, has received extensive attention in recent years. . In particular, chimeric antigen receptor (CAR)-modified T cell (CAR-T) technology has achieved rapid development and has shown strong efficacy in the treatment of hematological malignanc...

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Problems solved by technology

At present, more studies are using DC-derived exosomes to carry tumor-specific anti...

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