Use of combination of ROMK inhibitor and ARB in preparation of drug for treating and/or preventing hypertension or cardiac failure
A technology of inhibitors and uses, applied in the field of use of ROMK inhibitors and ARBs in the preparation of medicines for the treatment and/or prevention of hypertension or heart failure, and can solve problems such as unknown synergies
Inactive Publication Date: 2018-06-05
JIANGSU HENGRUI MEDICINE CO LTD
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Problems solved by technology
[0011] Patent applications WO2010129379, WO2013062900, WO2014099633, WO2013090271 disclose combinations of ROMK inhibitors and some angiotensin II receptor antagonists, but it is unknown whether they have synergistic effects
Method used
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Embodiment 1
[0077] Embodiment 1, the influence of composition of the present invention on blood pressure and heart rate of spontaneously hypertensive rats
[0078] Test product: Azilsartan ethanolamine salt (formula (I'-1) or formula (II'-1)) (can be prepared according to the method in patent application WO2012097697A1), ROMK inhibitor compound A (can be prepared according to the patent application Preparation by the method in application WO2016091042A1).
[0079] Structure as shown in formula (I'-1) or formula (II'-1),
[0080]
[0081] Control drug: hydrochlorothiazide (HCTZ) was purchased commercially.
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The invention relates to use of the combination of an ROMK inhibitor and an ARB in the preparation of a drug for treating and / or preventing hypertension or cardiac failure.
Description
technical field [0001] The invention relates to the use of a ROMK inhibitor combined with an angiotensin II receptor antagonist (ARB) in the preparation of medicines for treating and / or preventing hypertension or heart failure. Background technique [0002] The renal outer medullary potassium channel (ROMK) is also called the inward rectifying potassium channel 1.1 (Kirl.1). Inhibiting the function of ROMK can prevent hypoemia. In the case of potassium disease, effective inhibition of Na + -K + -2Cl - The salt reabsorption function of the transport protein promotes the excretion of urine and has the effect of diuresis and blood pressure reduction. [0003] Patent application WO2016091042A1 (publication date 2016.06.16) discloses a ROMK inhibitor compound, the structure of which is shown in the following formula (I): [0004] [0005] Azilsartan medoxomil is an angiotensin II receptor antagonist (ARB) drug developed by Takeda Pharmaceutical Company in Japan for the tre...
Claims
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IPC IPC(8): A61K31/4545A61K31/4245A61P9/12A61P9/04
CPCA61K31/4545A61K31/4245A61K2300/00
Inventor 桂雨舟曹国庆杨昌永张连山
Owner JIANGSU HENGRUI MEDICINE CO LTD